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A New Cyclo-Oxygenase-2 Gene Variant in the Han Chinese Population is Associated with an Increased Risk of Gastric Carcinoma

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Abstract

Background and Objective: Cyclo-oxygenase-2 (COX-2, also known as prostaglandin synthase 2) influences carcinogenesis through regulation of angiogenesis, apoptosis, and cytokine expression. COX-2 is encoded by the genePTGS2. Several studies have suggested thatPTGS2 single-nucleotide polymorphisms (SNPs) are involved in gastrointestinal carcinogenesis. In this study, we observed thePTGS2 Val511Ala (5939T/C) polymorphism in the Chinese population for the first time, and investigated whether this polymorphism might contribute to gastric cancer in a case-control study conducted in the Gansu province of China, a high-risk area for gastric cancer.

Methods: We determined the genotypes of 110 gastric cancer patients and 138 controls using polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) analysis. Data were statistically analyzed using a chi-squared test and a logistic regression model.

Results and Conclusion: In our analysis,PTGS2 5939C allele carriers were at increased risk of gastric cancer (odds ratio [OR] 1.742; 95% confidence interval [CI] 1.009, 3.005; p = 0.045). We also found an interaction betweenHelicobacter pylori infection, a family history of gastric cancer, and presence of the 5939C allele. This study further indicated thatH. pylori-positive status and family history jointly contribute to a higher risk of gastric cancer.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (project approval no. 30870364). The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Second Hospital of Lanzhou University, Lanzhou, Gansu, China

    Yumin Li & Tao Liu

  2. Key Laboratory of Digestive System, Lanzhou, Gansu, China

    Yumin Li, Wenting He & Tao Liu

  3. First Hospital of Lanzhou University, Lanzhou, Gansu, China

    Wenting He & Quanbao Zhang

Authors
  1. Yumin Li
  2. Wenting He
  3. Tao Liu
  4. Quanbao Zhang

Corresponding author

Correspondence to Yumin Li.

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Li, Y., He, W., Liu, T.et al. A New Cyclo-Oxygenase-2 Gene Variant in the Han Chinese Population is Associated with an Increased Risk of Gastric Carcinoma.Mol Diag Ther14, 351–355 (2010). https://doi.org/10.1007/BF03256392

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