1. H.W. Davenport,Gastric mucosal injury by fatty and acetylsalicylic acids, Gastroenterology46, 245–253 (1964).

   PubMed  Google Scholar 

2. J.R. Vane,Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs, Nature New Biol.231, 232–235 (1971).

   PubMed  Google Scholar 

3. G.A. Higgs andB.J.R. Whittle, The therapeutic and toxic effects of anti-inflammatory drugs which interfere with arachidonic acid metabolism. InClinical Pharmacology and Therapeutics — Proc. First Word Congress pp. 272–287. (Ed.P. Turner) Macmillan, London 1980.

   Google Scholar 

4. A. Robert, J.E. Nezamis, C. Lancaster andA.J. Hanchar,Cytoprotection by prostaglandins in rats, Gastroenterology77, 433–443 (1979).

   PubMed  Google Scholar 

5. B.J.R. Whittle, Actions of prostaglandins on gastric mucosal blood flow. InGastro-intestinal blood flow, pp. 180–191. (Ed.L.P. Fielding) Churchill Livingstone, Edinburgh 1980.

   Google Scholar 

6. S. Moncada, J.A. Salmon, J.R. Vane andB.J.R. Whittle,Formation of prostacyclin (PGI₂)and its product, 6-oxo-PGF_1αby the gastric mucosa of several species, J. Physiol.275, 4–5 (1977).

   Google Scholar 

7. B.J.R. Whittle,Role of prostaglandins in the defense of the gastric mucosa, Brain Res. Bull.5 (suppl. 1), 7–14 (1980).

   Article PubMed  Google Scholar 

8. B.J.R. Whittle,Arachidonic acid metabolites and the gastro-intestinal toxicity of anti-inflammatory agents, Prostaglandins21 (suppl.), 113–118 (1981).

   Article  Google Scholar 

9. G.L. Kauffman, B.J.R. Whittle, D. Aures andM.I. Grossman,Effects of prostacyclin and a stable analogue on gastric acid secretion and mucosal blood flow in unanaesthetised dogs, Clin. Res.26, 662 (1978).

   Google Scholar 

10. A.A. Allen andA. Garner,Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection, Gut21, 249–262 (1980).

    PubMed  Google Scholar 

11. P. Schiantarelli andS. Cadel,Piroxicam pharmacologic activity and gastrointestinal damage by oral and rectal route. Comparison with oral indometacin and phenylbutazone, Arzneimittel-Forsch./Drug Res.31, 87–92 (1981).

    Google Scholar 

12. U. Cioli, S. Putzolu, V. Rossi, P. Scorza Barcellona andC. Corradino,The role of direct tissue contact in the production of gastrointestinal ulcers by anti-inflammatory drugs in rats, Toxic. appl. Pharmac.50, 283–289 (1979).

    Article  Google Scholar 

13. K.D. Rainsford andM.W. Whitehouse,Gastric irritancy of aspirin and its congeners: anti-inflammatory activity without this side-effect, J. Pharm. Pharmac.28, 599–601 (1976).

    Google Scholar 

14. K.D. Rainsford andM.W. Whitehouse,Anti-inflammatory/anti-pyretic salicylic acid esters with low gastric ulcerogenic activity, Agents and Actions10, 451–456 (1980).

    PubMed  Google Scholar 

15. M.W. Whitehouse andK.D. Rainsford,Esterification of acidic anti-inflammatory drugs suppresses their gastrotoxicity without adversely affecting their anti-inflammatory activity in rats, J. Pharm. Pharmac.32, 795–796 (1980).

    Google Scholar 

16. C.A. Winter, E.A. Risley andG.W. Nuss,Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs, Proc. Soc. exp. Biol. Med.111, 544–547 (1962).

    Google Scholar 

17. P. Schiantarelli, S. Cadel, D. Acerbi andL. Pavest,Anti-inflammatory activity and bioavilability of per cutaneous piroxicam. Arzneimittel-Forsch./Drug Res.,32, 230–235 (1982).

    Google Scholar 

18. F. Awouters, C.J.E. Niemegeers, P.M.H. Lenaert andP.A.J. Janssen,Suprofen, a potent antagonist of ultraviolet-erythema in guinea-pig, Arzneimittel-Forsch./Drug Res.25, 1509–1511 (1975).

    Google Scholar 

19. J.T. Litchfield andF. Wilcoxon,A simplified method of evaluating dose-effect experiments, J. Pharmac. exp. Ther.96, 99–113 (1949).

    Google Scholar 

20. J.T. Siegmund, R. Cadmus andG. Lu,A method for evaluating both non-narcotic and narcotic analgesics, Proc. Soc. exp. Biol. Med.95, 729–731 (1957).

    PubMed  Google Scholar 

21. H.M. von Hattingberg, D. Brockmeier andG. Kreuter,Rotative iterative procedure (RIP) for estimating hybrid constants in multicompartmental analysis on desk computers, Eur. J. Clin. Pharmac.11, 382–388 (1977).

    Google Scholar 

22. A. Robert,Current history of cytoprotection, Prostaglandins21 (suppl.), 89–96 (1981).

    Article PubMed  Google Scholar 

23. A. Robert,Gastric cytoprotection by sodium salicylate, Prostaglandins21 (suppl.), 139–146 (1981).

    Article PubMed  Google Scholar 

Download references