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References
Steinbusch H. W. M., and Nieuwenhuys R. 1983 The raphe nuclei of the rat brain stem; A cytoarchitectonic and immunohistochemical study. Pages 131–207,in Emson PC (ed.) Chemical Neuroanatomy, study. Pages 131 Raven Press.
Dahlström A., and Fuxe K. 1965 Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brainstem neurons. Acta physiol Scand 62(suppl 232):1–55.
Frazer A., and Hensler J. G. 1994. Serotonin. In: Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, 5th edition, Pages 283–308,in Siegel G. J., Agranoff B. W., Albers R. W., and Molinoff P. B., (eds.) Raven Press, Ltd., New York.
Lopez-Ibor J. J. 1988 The involvement of serotonin in psychiatric disorders and behavior. Br J Psychiat 153 (supplement 3):26–39.
Korf J. 1985 Turnover rate assessments of cerebral neurotransmitter amines and acetylcholine. Pages 407–456,in Boulton AA Baker GB and Baker JM, (eds.), Neuromethods Vol. 2, Humana Press, Clifton, NJ.
Boadle-Biber, M. C., Johannessen, J. N., Narasimhachari, N., and Phan, T.-H. 1986 Tryptophan hydroxylase: Increase in activity by electrical stimulation of serotonergic neurons. Neurochem. Int 8: 83–92.
Vanier M., Tsuiki K., Grdiša M., Worsley K., and Diksic M. 1995 Determination of the lumped constant for the α-methyl-tryptophan method of estimating the rate of serotonin synthesis. J. Neurochem. 64, 624–635.
Mück-Šeler D., and Diksic M. 1995 The acute effects of reserpine and NSD-1015 on the brain 5-HT synthesis rate measured by the autoradiographic method. Neuropsychopharmacol. 12:251–262.
Lane J. D., Co C. T., and Smith J. E. 1977 Determination of simultaneous turnover of serotonin, dopamine and norepinephrine in the telencephalon of unrestrained behaving rats. Life Sciences 21:1101–1108.
Lin R. C., Costa E., Neff N. E., Wang C. T., and Ngai S. H. 1969 In vivo measurement of 5-hydroxytryptamine turnover rate in the rat brain from the conversion of14C-tryptophan to14C-5-hydroxytryptamine. J Pharmacol Exp Therap 170(2):232–238.
Tracqui P., Brezillon P., Staub J. F., Morot-Gaudry Y., Hamon M., and Perault-Staub A. M. 1983 Model of brain serotonin metabolism I. Structure determination-parameter estimation. Amer J Physiol 244:R193-R205.
Tracqui P., Brezillon P., Staub J. F., Morot-Gaudry Y., Hamon M., and Perault-Staub A. M. 1983 Model of brain serotonin metabolism II. Physiological interpretation. Amer J. Physiol. 244: R206-R215.
Paltkovits K., Brownstein M., Kizer J. S., Saavedra J. M., Kopin I. J. 1976 Effect of stress on serotonin and tryptophan hydroxylase activity of brain nuclei. In: Catecholamines and Stress (Usdin E, et al., eds.), Oxford, Pergamon Press, pp 51–59.
Tappaz M. L., and Pujol J.-F. 1980 Estimation of the rate of tryptophan hydroxylation in vivo; A selective microassay in discrete rat brain nuclei. J. Neurochem. 34:933–940.
Sourkes T. L. 1971 Alpha-methyltryptophan and its actions on tryptophan metabolism. Fed. Proc. 30:897–903.
Gal E. M., and Christiansen P. A. 1975 Alpha-methyltryptophan: effect on cerebral monooxygenases in vitro and in vivo. J. Neurochem. 24:89–95.
Schirlin D., Gerhart F., Hornsperger J. M., Hamon M., Wagner, J., and Jung M. J. 1988 Synthesis and biological properties of α-mono-and α-difluoromethyl derivatives of tryptophan and 5-hydroxytryptophan. J. Med. Chem. 31:30–36.
Diksic M., Nagahiro S., Sourkes T. L., and Yamamoto Y. L. 1990 A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model. J. Cereb. Blood Flow Metab. 9:1–12.
Madras, B. K., and Sourkes, T. L. 1965 Metabolism of α-methyl-tryptophan. Biochem. Pharmacol., 14:1499–1506.
Moir A. T. B., and Eceleston D. 1968 The effects of precursor loading in the cerebral metabolism of 5-hydroxyindoles. J. Neurochem. 15:1093–1108.
Burns D., London J., Brunswick D. J., Pring M., Garfinkel D., Rabinowitz J. L., and Mendels J. 1976 A kinetic analysis of 5-hydroxyindoleacetic acid excretion from rat brain and csf. Biol. Psychiat. 11(2):125–157.
Nagahiro S., Takada A., Diksic M., Sourkes T. L., Missala K., and Yamamoto YL 1990 A new method to measure brain serotonin synthesis in vivo. II. A practical autoradiographic method tested in normal and lithium-treated rats. J. Cereb. Blood Flow Metab. 10, 13–21.
Missala, K., and Sourkes, T. L. 1988 Functional cerebral activity of an analogue of serotonin formed in situ. Neurochem. Int., 12: 209–214.
Nagahiro, S., Diksic, M., and Yamamoto, Y. L., 1990 Non-invasive autoradiographic method for measurement of axonal transport in serotoninergic neurons in the rat brain. Brain Res., 506:120–128.
Diksic M., Nagahiro S., and Grdiša M. 1995 The regional rate of serotonin synthesis estimated by the α-methyl-tryptophan method in rat brain from a single time point. J. Cerb. Blood Flow Metabol. 15:806–813.
Diksic M. 1991. In vivo autoradiographic methods for the rate of serotonin synthesis and axonal transport measurements in brain. In:Current Aspects of the Neurosciences. Vol. 3, N.N. Osborne (Ed.) MacMillan Press, London pp. 37–77.
Mzengeza S., Venkatachalam T. K., and Diksic M. 1995 Asymmetric Radiosynthesis of α-[11C]Methyl-L-Tryptophan for PET Studies. Nucl Med Biol 22:303–307.
Diksic M., Nagahiro S., Chaly T., Sourkes T. L., Yamamoto Y. L., and Feindel W. 1991 Serotonin synthesis rate measured in living dog brain by positron emission tomography. J. Neurochem. 56:153–162.
Kuhar M. J., Roth R. H., and Aghajanian G. K. 1971 Selective reduction of tryptophan hydroxylase activity in rat forebrain after midbrain raphe lesions. Brain Res. 35:167–176.
Hamon M., Bourgoin S., Artaud F., and Nelson 1981 Regulatory properties of neuronal tryptophan hydroxilase. In: Advances in experimental medicine and biology, Vol. 133, (Haber B., Gabay S., Issidorides M. R., Alivisatos S. G. A. (Eds.), Plenum Press, New York, pp. 231–251.
Takada A., Grdisa M., Diksic M., Gjedde A., and Yamamoto Y. L. 1993 Rapid steady-state analysis of the blood-brain transfer of L-Trp in rat, with special reference to the plasma protein bindig. Neurochem. Int. 23, 351–359.
Diksic M. 1991 Imaging of the serotoninergic neuronal system in the brain. Periodicum Biologorum 93(4):525–532.
Tsuiki K., Mück-Šeler D., and Diksic M. 1995 Autoradiographic evaluation of the influence of hypothalamic 5,7-dihydroxytryptamine lesion on brain serotonin synthesis. Biochem. Pharmac. 49: 633–642.
Ljubić V, Raison S, Hamel E, Diksic M, Weissmann D. 1994. Correlation between serotonin (5-HT) and tryptophan hydroxylase (TPH) contents in 5-HT neurons and fibers: effects of 5,7-dihydroxytryptamine (5,7-DHT) lesion in the dorsolateral hypothalamus. 24th Ann Meet, Soc for Neurosc, Abstract 128.5.
Cohen Z., Tsuiki K., Takada A., Beaudet A., Diksic M., and Hamel E. 1995 In vivo synthesized radioactively labelled α-methyl serotonin as a selective tracer for visualization of brain serotonin neurons. Synapse 21:21–28.
Goodnick P. J., and Gershon S. 1985 Lithium. In: Handbook of Neurochemistry, Vol. 9, 2nd ed. (Lajtha A., Ed.), New York, Plenum Press, pp. 103–149.
Sheard M. H., and Aghajanian G. K. 1970 Neuronaly activated metabolism of brain serotonin: effect of lithium. Life Sci. 9:285–290.
Mandell A. J., and Knapp S. 1979 Asymmetry and mood, emergent properties of serotonin regulation. Arch. Gen. Psychiatry 36: 909–916.
Perez-Cruet J., Tagliamonte A., Tagliamonte P., and Gessa G. L. 1971 Stimulation of serotonin synthesis by lithium. J. Pharmacol. Exp. Ther. 178:325–330.
Takada A., Grdiša M., and Diksic M. 1992 Blood-brain barrier transfer of L-Trp and α-MTrp in Li-treated rats. Neurochem. Int. 21:513–519.
Tsuiki K., Takada A., Grdiša M. and Diksic M. 1994 Effect of hypothalamic 5,7-dihydroxytryptamine lesion on anterograde transport of serotonin along the medial forebrain bundle. Neurochem. Int. 24:231–239.
Paxinos, G., and Watson, C. 1986 In: The Rat Brain in Stereotaxic Coordinates, 2nd edition. Academic Press, New York.
Frankfurt M., and Azmitia E. 1983 The effect of intracerebral injections of 5,7-dihydroxytryptamine and 6-hydroxydopamine on the serotonin-immunoreactive cell bodies and fibers in the adult rat hypothalamus. Brain Res. 261, 91–99.
Parent A., Descarries, L., and Beauder, A. 1981. Organization of ascending serotonin systems in the adult rat brain. A radioauto-graphic study after intraventricular administration of [3H]5-hydroxytryptamine. Neuroscience 5:115–138.
O'Hearn, E., and Molliver, M. E. 1984. Organization of raphecortical projections in rat: A quantitative retrograde study. Brain Res. Bull. 13:709–726.
Azmitia, E., and Segal, M. 1978. An autoradiographic analysis of the differential ascending projections of the dorsal and medial raphe nuclei in the rat. Brain Res. 196:405–415.
Clewans, C. S., and Azmitia, E. 1984. Tryptophan hydroxylase in hippocampus and midbrain following unilateral injection of 5,7-dihydroxytryptamine. Brain Res. 307, 125–133.
Bendotti, C., Sernadio, A., Forloin, G., Angeretti, N., and Samanin, R. 1990. Increased tryptophan hydroxylase mRNA in raphe serotoninergic neurons spared by 5,7-dihydroxy-tryptamine. Mol. Brain Res. 8, 343–348.
Stachowiak, M. K., Sticker, E. M., Jacoby, C. H., and Zigmond, M. J. 1986. Increased tryptophandroxylase activity in serotonergic nerve terminals spared by 5,7-dihydroxy-tryptamine. Biochem. Pharmac. 35, 1241–1248.
Kosofsky, B. E., and Molliver, M. E. 1987. The serotoninergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei. Synapse 1:153–168.
Molliver, M. E. 1987. Serotoninergic neuronal system: what their anatomical organization tells us about function. J. Clin. Psychopharmacol. 7, 3S-23S.
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Authors and Affiliations
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St., H3A 2B4, Montreal, Quebec, Canada
Mirko Diksic
Division of Molecular Medicine, Institute Rudjer Bošković, 4100, Zagreb, Croatia
Mira Grdiša
- Mirko Diksic
Search author on:PubMed Google Scholar
- Mira Grdiša
Search author on:PubMed Google Scholar
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Special issue devoted to Dr. Leon S. Wolfe.
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Diksic, M., Grdiša, M. α-Methyl-l-tryptophan as a tracer to study brain serotonergic system.Neurochem Res20, 1353–1360 (1995). https://doi.org/10.1007/BF00992511
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