1. Baer AN, Costello PB, Green FA (1990) Free and esterified 13 (R,S)-hydroxyoctadecadienoic acids: principal oxygenase products in psoriatic skin scales. J Lipid Res 31: 125–130

   Google Scholar 

2. Barr RM, Wong E, Mallet AI, Olins LA, Greaves MW (1984) The analysis of arachidonic acid metabolites in normal, uninvolved and lesional psoriatic skin. Prostaglandins 28: 57–65

   Google Scholar 

3. Bartel RL, Marcelo CL, Voorhees JJ (1987) Partial characterization of phospholipase C activity in normal, psoriatic uninvolved, and lesional epidermis. J Invest Dermatol 88: 447–451

   Google Scholar 

4. Bartlett G (1959) Phosphorus assay in column chromatography. J Biol Chem 234: 466–468

   Google Scholar 

5. Brezinski ME, Serhan CN (1990) Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids. Proc Natl Acad Sci USA 87: 6248–6252

   Google Scholar 

6. Brinkman HJ, van-Buul-Wortelboer MF, van-Mourik JA (1991) Selective conversion and esterification of monohydroxyeicosatetraenoic acids by human vascular smooth muscle cells: relevance to smooth muscle cell proliferation. Exp Cell Res 192: 87–92

   Google Scholar 

7. Buchanan MR, Bastida E (1988) Endothelium and underlying membrane reactivity with platelets, leukocytes and tumor cells: regulation by the lipoxygenase-derived fatty acid metabolites, 13-HODE and HETES. Med Hypotheses 27: 317–325

   Google Scholar 

8. Camp RD, Mallet AI, Woollard PM, Brain SD, Black AK, Greaves MW (1983) The identification of hydroxy fatty acids in psoriatic skin. Prostaglandins 26: 431–447

   Google Scholar 

9. Chan CC, Duhamel L, Ford-Hutchison A (1985) Leukotriene B4 and 12-hydroxyeicosatetraenoic acid stimulate epidermal proliferation in vivo in the guinea pig. J Invest Dermatol 85: 333–334

   Google Scholar 

10. Cunningham FM, Woollard PM (1987) 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid is a chemoattractant for human polymorphonuclear leucocytes in vitro. Prostaglandins 34: 71–78

    Google Scholar 

11. Dowd PM, Kobza-Black A, Woollard PM, Camp RD, Greaves MW (1985) Cutaneous responses to 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE). J Invest Dermatol 84: 537–541

    Google Scholar 

12. Dowd PM, Black AK, Woollard PW, Greaves MW (1987) Cutaneous responses to 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) and 5,12-dihydroxyeicosatetraenoic acid (leukotriene B4) in psoriasis and normal human skin. Arch Dermatol Res 279: 427–434

    Google Scholar 

13. Duell EA, Ellis CN, Voorhees JJ (1988) Determination of 5-, 12-, and 15-lipoxygenase products in keratomed biopsies of normal and psoriatic skin. J Invest Dermatol 91: 446–450

    Google Scholar 

14. Engels F, Willems H, Nijkamp FP (1986) Cyclooxygenase-catalyzed formation of 9-hydroxylinoleic acid by guinea pig alveolar macrophages under non-stimulated conditions. FEES Lett 209: 249–253

    Google Scholar 

15. Fisher GJ, Talwar HS, Baldassare JJ, Henderson PA, Voorhees JJ (1990) Increased phospholipase C-catalyzed hydrolysis of phosphatidylinositol-4,5-bisphosphate and 1,2-sn-diacylglyce-rol content in psoriatic involved compared to uninvolved and normal epidermis. J Invest Dermatol 95: 428–435

    Google Scholar 

16. Fogh K, Kill J, Herlin T, Ternowitz T, Kragballe K (1987) Heterogeneous distribution of lipoxygenase products in psoriatic skin lesions. Arch Dermatol Res 279: 504–511

    Google Scholar 

17. Fogh K, SØgaard H, Herlin T, Kragballe K (1988) Improvement of psoriasis vulgaris after intralesional injections of 15-hydroxyeicosatetraenoic acid (15-HETE). J Am Acad Dermatol 18: 279–285

    Google Scholar 

18. Fogh K, Herlin T, Kragballe K (1989) Eicosanoids in acute and chronic psoriatic lesions: leukotriene B4, but not 12-hydroxy-eicosatetraenoic acid, is present in biologically active amounts in acute guttate lesions [see comments]. J Invest Dermatol 92: 837–841

    Google Scholar 

19. Forster S, Ilderton E, Norris JF, Summerly R, Yardley HJ (1985) Characterization and activity of phospholipase A2 in normal human epidermis and in lesion-free epidermis of patients with psoriasis or eczema. Br J Dermatol 112: 135–147

    Google Scholar 

20. Fuse I, Iwanaga T, Tai HH (1989) Phorbol ester, 1,2-diacyl-glycerol, and collagen induce inhibition of arachidonic acid incorporation into phospholipids in human platelets. J Biol Chem 264: 3890–3895

    Google Scholar 

21. Goetzl E, Woods J, Gorman R (1977) Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid. J Clin Invest 59: 179–183

    Google Scholar 

22. Gordon EE, Gordon JA, Spector AA (1991) HETEs and coronary artery endothelial cells: metabolic and functional interactions. Am J Physiol 261: C623-C633

    Google Scholar 

23. Green FA (1989) Generation and metabolism of lipoxygenase products in normal and membrane-damaged cultured human keratinocytes. J Invest Dermatol 93: 486–491

    Google Scholar 

24. GrØn B, Iversen L, Ziboh V, Kragballe K (1993) The distribution of monohydroxy fatty acids in specific human epidermal phospholipids. Exp Dermatol 2: 38–44

    Google Scholar 

25. Haas TA, Bastida E, Nakamura K, Hullin F, Admirall L, Buchanan MR (1988) Binding of 13-HODE and 5-, 12- and 15-HETE to endothelial cells and subsequent platelet, neutrophil and tumor cell adhesion. Biochim Biophys Acta 961: 153–159

    Google Scholar 

26. Hammarström S, Hamberg M, Samuelsson B, Duell E, Stawiski M, Voorhees J (1975) Increased concentrations of nonesterified arachidonic acid, 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2-alfa in epidermis of psoriasis. Proc Natl Acad Sci USA 72: 5130–5134

    Google Scholar 

27. Henricks PA, Engels F, van-der-Vliet H, Nijkamp FP (1991) 9- and 13-hydroxy-linoleic acid possess chemotactic activity for bovine and human polymorphonuclear leukocytes. Prosta-glandins 41: 21–27

    Google Scholar 

28. Kragballe K, Pinnamaneni G, Desjarlais L, Duell EA, Voorhees JJ (1986) Dermis-derived 15-hydroxy-eicosatetraenoic acid inhibits epidermal 12-lipoxygenase activity. J Invest Dermatol 87: 494–498

    Google Scholar 

29. Ku G, Thomas CE, Akeson AL, Jackson RL (1992) Induction of interleukin 1-beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid. J Biol Chem 267: 14183–14188

    Google Scholar 

30. Kühn H, Belkner J, Wiesner R, Brash AR (1990) Oxygenation of biological membranes by the pure reticulocyte lipoxygenase. J Biol Chem 265: 18351–18361

    Google Scholar 

31. Legrand AB, Lawson JA, Meyrick BO, Blair IA, Oates JA (1991) Substitution of 15-hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway. J Biol Chem 266: 7570–7577

    Google Scholar 

32. Miller CC, Ziboh VA (1990) Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). J Invest Dermatol 94: 353–358

    Google Scholar 

33. Miller CC, Tang W, Cho Y, Ziboh VA (1993) Selective incorporation of HETEs into epidermal phospholipids. In: Bailey JM (eds) Prostaglandins, leukotrienes, lipoxins and PAF. Plenum Press, New York, pp 409–419

    Google Scholar 

34. Moch D, Schewe T, Kuhn H, Schmidt D, Buntrock P (1990) The linoleic acid metabolite 9DS-hydroxy-10,12(E,Z)-octa-decadienoic acid is a strong proinflammatory mediator in an experimental wound healing model of the rat. Biomed Biochim Acta 49: 201–207

    Google Scholar 

35. Moore SA, Prokuski LJ, Figard PH, Spector AA, Hart MN (1988) Murine cerebral microvascular endothelium incorporate and metabolize 12-hydroxyeicosatetraenoic acid. J Cell Physiol 137: 75–85

    Google Scholar 

36. Pfannkuche HJ, Kaever V, Resch K (1986) A possible role of protein kinase C in regulating prostaglandin synthesis of mouse peritoneal macrophages. Biochem Biophys Res Commun 139: 604–611

    Google Scholar 

37. Spector AA, Gordon JA, Moore SA (1988) Hydroxyeicosatetraenoic acids (HETEs). Prog Lipid Res 27: 271–323

    Google Scholar 

38. Stenson W, Parker C (1979) Metabolism of arachidonic acid in ionophore-stimulated neutrophils. J Clin Invest 64: 1457–1465

    Google Scholar 

39. Turner S, Tainer J, Lynn W (1975) Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets. Nature 257: 680–681

    Google Scholar 

40. Vanderhoek J, Bryant R, Bailey J (1980) 15-hydroxy-5,8,11,13-eicosatetraenoic acid. A potent and selective inhibitor of platelet lipoxygenase. J Biol Chem 255: 5996–5998

    Google Scholar 

41. Vanderhoek J, Bryant R, Bailey J (1980) Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid. J Biol Chem 255: 10064–10065

    Google Scholar 

42. Wevers A, Wirnitzer U, Schaarschmidt H, Hegemann L, Mahrle G (1992) Gene expression of protein kinase C subtypes in normal and psoriatic epidermis. Arch Dermatol Res 284: 5–7

    Google Scholar 

43. Wollard PM, Cunningham FM, Murphy GM, Camp RD, Derm FF, Greaves MW (1989) A comparison of the proinflammatory effects of 12(R)- and 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid in human skin. Prostaglandins 38: 465–471

    Google Scholar 

Download references