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Abstract
We determined the complete genomic sequence of the humanCD79b (Igβ/B29) gene. The CD79b gene product is associated with the membrane immunoglobulin signaling complex which is composed of immunoglobulin (Ig) itself, associated in a noncovalent fashion with CD79b and a second polypeptide chain, CD79a (Igα/mb1). The sequence and exon/intron organization of the human and mouseCD79b genes are highly similar. The gene organization suggests that some variant forms of CD79b may arise by virtue of alternative splicing of mRNA. In addition, a number of conserved regulatory sequences commonly found inIg genes are present in sequences which flank the humanCD79b gene. Some of these sequences are distinct from those found in theCD79a promoter. These differences may explain why transcription ofCD79b, but notCD79a, is observed in plasma cells. A newTaq 1 restriction fragment length polymorphism is described that is not associated with any structural polymorphisms of the expressed CD79b polypeptide.
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Author information
Shiori Hashimoto
Present address: Department of Neurology, Tokyo Women's Medical College, 10 Kawada-cho, Shinjuku-ku, Tokyo, Japan
Authors and Affiliations
Department of Medicine, North Shore University Hospital, 350 Community Drive, 11030, Manhasset, NY, USA
Shiori Hashimoto, Nicholas Chiorazzi & Peter K. Gregersen
Department of Medicine, Cornell University Medical College, 10021, New York, NY, USA
Nicholas Chiorazzi & Peter K. Gregersen
- Shiori Hashimoto
Search author on:PubMed Google Scholar
- Nicholas Chiorazzi
Search author on:PubMed Google Scholar
- Peter K. Gregersen
Search author on:PubMed Google Scholar
Additional information
The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned the accession number L27587
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Hashimoto, S., Chiorazzi, N. & Gregersen, P.K. The complete sequence of the human CD79b (lgβ/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism.Immunogenetics40, 145–149 (1994). https://doi.org/10.1007/BF00188178
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