Part of the book series:Handbook of Experimental Pharmacology ((HEP,volume 135 / 2))
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Abstract
Ovulation inhibition by progestogens was postulated as early as 1921 by HABERLANDT. One year later, a similar action was ascribed to estrogens by FELLNER. In 1944, BICKENBACH and PAULIKOVICS succeeded in suppressing ovulation in a woman by means of daily injections of 20 mg progesterone. Hormonal contraception for all women, however, only became possible after orally active estrogens and progestogens had been developed. The basis for this revolution in birth control was broμght about by BUTENANDT, INHoFFEN, HOHLWEG, MARKER, DJERASSI and many other scientists.
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References
Aznar-Ramos R, Giner -Velasquez J, Lara -Ricalde R, Martinez-Manautou J (1969) Incidence of side-effects with contraceptive placebo. Am J Obstet Gynecol 105:1144–1149
Back DJ, Barkfeldt JO, Breckenridge AM, Odlind V, Orme M, Park BK, Purba H, Tjia J, Victor A (1982) The enzyme inducing effect of rifampicin in the rhesus monkey and its lack of interaction with oral contraceptive steroids. Contraception 25:307–316
Back DJ, Grimmer SFM, Orme ML’E, Proudlove C, Mann RD, Breckenridge AM (1988) Evaluation of committee on safety of medicines yellow card reports on oralcontraceptive-drμg interactions with anticonvulsants and antibiotics. Br J Clin Pharmacol 25:527–532
Back DJ, Orme MLE (1990) Pharmacokinetic drμg interactions with oral contraceptives. Clin Pharmacokinet 18:472–484
Ball MJ,Ashwell E, Jackson M, Gillmer MDG (1990) Comparison of two triphasic contraceptives with different progestogens: effects on metabolism and coagulation proteins. Contraception 41:363–376
Bloemenkamp KWM, Rosendaal FR, Helmerhorst FM, Buller HR, Vandenbroucke JP (1995) Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third generation progestagen. Lancet 346:1593–1596
Bosch FX, Munoz N, de Sanjose S, Izarzμgaza I, Gili M, Viladiu P et al. (1992)Risk factors for cervical cancer in Colombia and Spain. Int J Cancer 52:750–758
Bracken MB (1990) Oral contraception and congenital malformations in offspring: A review and meta-analysis of the prospective studies. Obstet Gynecol 76:552–557
Brinton LA, Hμggins GR, Lehman HF, Mallin K, Savitz DA, Trapido E, Rosenthal J, Hoover R (1986) Long-term use of oral contraceptives and risk of invasive cervical cancer. Int J Cancer 38:339–344
Brosens IA, Pijnenborg R (1976) Comparative study of the estrogenic effect of ethinylestradiol and mestranol on the endometrium. Contraception 14:679–685
Cohen H, Mackie IJ, Walshe K, Gillmer MDG, Machin SJ (1988) A comparison of the effects of two triphasic oral contraceptives on haemostasis. Br J Haematol 69:259–263
Collaborative Group on Hormonal Factors in Breast Cancer (1996) Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53297 women with breast cancer and 100239 women without breast cancer from 54 epidemiological studies. Lancet 347:1713–27
Croft P, Hannaford PC (1989) Risk factors for acute myocardial infarction in women: evidence from the Royal College of General Practitioners’ oral contraception study. Br Med J 298:165–168
Crook D, Godsland IF, Wynn V (1988) Oral contraceptives and coronary heart disease: modulation of glucose tolerance and plasma lipid risk factors by progestins. Am J Obstet Gynecol 158:1612–1620
Daly L, Bonnar J (1990) Comparative studies of 30.μg ethinylestradiol combined with gestodene and desogestrel on blood coagulation, fibrinolysis, and platelets. Am J Obstet Gynecol 163:430–437
Derkx FHM, Stunkel C, Schalekamp MPA, Visser W, Huisveld IH, Schalekamp MADH (1986) Immunoreactive renin, prorenin, and enzymatically active renin in plasma during pregnancy and in women taking oral contraceptives. J Clin Endocrinol Metab 63:1008–1015
Doss M (1984) Porphyrie und hormonale Kontrazeptiva. Dtsch Med Wschr 109:1701–1702
Duffy TJ, Ray R (1984) Oral contraceptive use: prospective follow-up of women with suspected glucose intolerance. Contraception 40:197–208
Fawer R, Dettling A, Weihs D, Welti H, Schelling JL (1978) Effect of the menstrual cycle, oral contraception and pregnancy on forearm blood flow, venous distensibility and clotting factors. Eur J Clin Pharmacol 13:251–257
Fern M, Rose DP, Fern EB (1978) Effect of oral contraceptives on plasma androgenic steroids and their precursors. Obstet Gynecol 51:541–544
Fisch IR, Frank J (1977) Oral contraceptives and blood pressure. J Am Med Ass 237:2499–2503
Garg SK, Chase HP, Marshall G, Hoops SL, Holmes DL, Jackson WE (1994) Oral contraceptives and renal and retinal complications in young women with insulindependent diabetes mellitus. J Am Med Ass 271:1099–1102
Gerstman BB, Piper JM, Tmita DK, Ferguson WJ (1991) Oral contraceptive estrogen dose and the risk of deep venous thromboembolic disease. Am J Epidemiol 133:32–36
Godet PG, May GR, Sutherland LR (1995) Meta-analysis of the role of oral contraceptive agents in inflammatory bowel disease. Gut 37:668–673
Godsland IF, Crook D (1994) Update on the metabolic effects of steroidal contraceptives and their relationship to cardiovascular disease risk. Am J Obstet Gynecol 170:1528–1536
Godsland IF,Crook D, Davenport M, Wynn V (1995) Relationships between blood pressure, oral contraceptive use and metabolic risk markers for cardiovascular disease. Contraception 52:143–149
Godsland IF, Crook D, Wynn V (1990) Low-dose oral contraceptives and carbohydrate metabolism. Am J Obstet Gynecol 163:348–353
Grodstein F, Colditz GA, Hunter DJ, Manson JE, Willett WC, Stampfer MJ (1994) A prospective study of symptomatic gallstones in women: relation with oral contraceptives and other risk factors. Obstet Gynecol 84:207–214
Hannaford PC, Kay CR, Vessey MP, Painter R, Mant J (1997) Combined oral contraceptives and liver disease. Contraception 55:145–151
Haspels AA (1994) Emergency contraception: a review. Contraception 50:101–108
Jick H, Jick SS, Gurewich V, Myeres MW, Vasilakis C (1995) Risk of idiopathic cardiovascular death and non-fatal venous thromboembolism in women using oral contraceptives with differing progestagen components. Lancet 346:1589–1593
Jung-Hoffmann C, Kuhl H (1987) Divergent effects of two low-dose oral contraceptives on sex hormone-binding globulin and free testosterone. Am J Obstet Gynecol 156:199–203
Jung-Hoffmann C, Kuhl H (1990) Intra- and interindividual variations in contraceptive steroid levels during 12 treatment cycles: no relation to irregular bleedings. Contraception 42:423–438
Jung-Hoffmann C, Heidt F, Kuhl H (1988) Effect of two oral contraceptives containing 30,μg ethinylestradiol and 75,μg gestodene or 150,μg desogestrel upon various hormonal parameters. Contraception 38:593–603
Kay CR (1982) Progestogens and arterial disease - evidence from the Royal College of General Practitioners’ study. Am J Obstet Gynecol 142:762–765
Knopp RH, LaRosa JC, Burkman RT (1993) Contraception and dyslipidemia. Am J Obstet Gynecol 168:1994–2005
Koster T, Small RA, Rosendaal FR, Helmerhorst FM (1995) Oral contraceptives and venous thromboembolism: a quantitative discussion of the uncertainties. J Int Med 238:31–37
Krauss RM, Burkman RT (1992) The metabolic impact of oral contraceptives. Am J Obstet Gynecol 167:1177–1184
Kudzma DJ, Bradley EM, Goldzieher JW (1972) A metabolic balance study of the effects of an oral steroid contraceptive on weight and body composition. Contraception 6:31–37
Kuhl H(1990a) Pharmacokinetics of estrogens and progestogens. Maturitas 12:171–197
Kuhl H(1994a)Wie Darmerkrankungen, Erniihrung, Rauchen und Alkohol die Wirkung von oralen Kontrazeptiva beeinflussen. Geburtsh Frauenheilk 54:M1–M10
Kuhl H (1994b)Wie sich orale Kontrazeptiva und Medikamente in ihrer Wirkung beeinflussen. Geburtsh Frauenheilk 54:M23–M30
Kuhl H (1996a) Comparative pharmacology of newer progestogens. Drμgs 51:188–215
Kuhl H (1996b) Effects of progestogens on haemostasis. Maturitas 24:1–19
Kuhl H, Gahn G, Romberg C, Althoff PH, Taubert HD (1985a) A randomized crossover comparison of two low-dose oral contraceptives upon hormonal and metabolic parameters: II.Effects on thyroid function, gastrin, STH, and glucose tolerance. Contraception 32:97–107
Kuhl H, Gahn G, Romberg C, Marz W, Taubert HD (1985b) A randomized cross-over comparison of two low-dose oral contraceptives upon hormonal and metabolic parameters: I. Effects upon sexual hormone levels. Contraception 31:583–593
Kuhl H, Marz W, Jung-Hoffmann C, Heidt F, Gross W (1990b) Time-dependent alterations and lipid metabolism during treatment with low-dose oral contraceptives. Am J Obstet Gynecol 163:363–369
Kuhl H, Marz W, Jung-Hoffmann C, Weber J, Siekmeier R, Gross W (1993) Effect on lipid metabolism of a biphasic desogestrel-containing oral contraceptive: divergent changes in apolipoprotein Band E and transitory decrease in Lp (a) levels. Contraception 47:69–83
Lemay A, Dodin Dewailly S, Grenier R, Huard J (1990) Attenuation of mild hyperandrogenic activity in postpubertal acne by a triphasic oral contraceptive containing low doses of ethynyl estradiol and d,l-norgestrel. J Clin Endocrinol Metab 71:8–14
Lembke S, Freund H (1990) EinftuB hormonaler Kontrazeptiva auf die Stimme. Z Arztl Fortb 84:47–49
Mandel FP, Geola FL, Lu JKH, Eggena P, Sambhi MP, Hershman JM, Judd HL (1982) Biologic effects of various doses of ethinyl estradiol in postmenopausal women. Obstet Gynecol 59:673–679
Mashchak CA, Lobo RA, Dozono-Takano R, Eggena P, Nakamura RM, Brenner PF, Mishell DR (1982) Comparison of pharmacodynamic properties of various estrogen formulations. Am J Obstet Gynecol 144:511–518
Mattson RH, Rebar RW (1993) Contraceptive methods for women with neurologic disorders. Am J Obstet Gynecol 168:2027–2032
McCann MF, Potter LS (1994) Progestin-only oral contraception: a comprehensive review. Contraception 50(Suppl.1):S1–S198
Meade TW ((1988) Risks and mechanisms of cardiovascular events in users of oral contraceptives. Am J Obstet Gynecol 158:1646–1652
Mishell DR (1982) Noncontraceptive health benefits of oral steroidal contraceptives. Am J Obstet Gynecol 142:809–816
Moltz L, Schwartz U, Hammerstein J (1980) Die klinische Anwendung von Antiandrogenen bei der Frau. Gynakologe 13:1–17
Neuberger J, Forman D, Doll R, Williams R (1986) Oral contraceptives and hepatocellular carcinoma. Br Med J 292:1355–1357
Olivieri O, Friso S, Manzato F, Grazioli S, Bernardi F, Lunghi B, Girelli D, Azzini M, Brocco G, Russo C, Corrocher R (1996) Resistance to activated protein C, associated with oral contraceptives use; effect of formulations, duration of assumption, and doses of oestro-progestins. Contraception 54:149–152
Palmer JR, Rosenberg L, Strom BL, Hadap S, Zauber AG, Warshauer ME, Shapiro S (1992) Oral contraceptive use and risk of cutaneous malignant melanoma. Cancer Causes Control 3:547–554
Parazzini F, LaVecchia C, Negri E, Franceschi S, Moroni S, Chatenoud L, Bolis G (1997) Case-control study of estrogen replacement therapy and risk of cervical cancer. Br Med J 315:85–88
Petersen KR, Skouby SO, Sidelmann J, Jespersen J (1994) Assessment of endothelial function during oral contraception in women with insulin-dependent diabetes mellitus. Metabolism 43:1379–1383
Petersen KR, Sidelmann J, Skouby SO, Jespersen J (1993) Effects of monophasic lowdose oral contraceptives on fibrin formation and resolution in young women. Am J Obstet Gynecol 168:32–38
Population Reports (1995) Injectables and implants - new era for injectables. Series K:1–31
Population Reports (1992) Decisions for Norplant programs. Series K:1–31
Rannevik G, Jeppson S, Kullander S (1972) Effect of oral contraceptives on the liver in women with recurrent cholestasis (hepatosis) during previous pregnancies. J Obstet Gynaecol Br Cmwlth 79:1128–1136
Rimm EB, Manson JE, Stampfer MJ, Colditz GA, Willett WC, Rosner B, Hennekens CH, Speizer FE (1992) Oral contraceptive use and risk of type 2 (non-insulindependent) diabetes mellitus in a large prospective study of women. Diabetologia 35:967–972
Rooks JB, Ory HW, Ishak K, Strauss LT, Greenspan JR, Paganini-Hill A, Tyler CW (1979) Epidemiology of hepatocellular adenoma. The role of oral contraceptive use. J Am Med Ass 242:644–-648
Rosenberg L (1991) The risk of liver neoplasia in relation to combined oral contraceptive use. Contraception 43:643–-652
Rosing J, Tans G, Nicolaes GAF, Thomassen MCLGD, van Oerie R, van der Ploeg PMEN, Heijnen P, Hamulyak K, Hemker HC (1997) Oral contraceptives and venous thrombosis: different sensitivities to activated protein C in women using second- and third- generation oral contraceptives. Br J Haematol 97:233–238
Roy S (1991) Nonbarrier contraceptives and vaginitis and vaginosis. Am J Obstet Gynecol 165:1240–1244
Royal College of General Practitioners’ Oral Contraceptive Study (1977) Effect on hypertension and benign breast disease of progestagen component in combined oral contraceptives. Lancet 1:624
Rubin GL, Ory HW, Layde PM (1982) Oral contraceptives and pelvic inflammatory disease. Am J Obstet Gynecol 144:630–-635
Schlesselman JJ (1991) Oral contraceptives and neoplasia of the uterine corpus. Contraception 43:557–580
Schweitzer IL, Weiner JM, McDeak CM, Thursby MW (1975) Oral contraceptives in acute viral hepatitis. J Am Med Ass 233:979–980
Shaaban MM, Hammad WA, Fathalla MF, Ghaneimah SA, EI-Sharkawy MM, Salim TH,Ali MY, Liao WC, Smith SC (1982) Effects of oral contraception on liver function tests and serum proteins in women with past viral hepatitis. Contraception 26:65–74
Stanczyk FZ (1997) Pharmacokinetics of the new progestogens and influence of gestodene and desogestrel on ethinylestradiol metabolism. Contraception 55:273–282
Stanczyk FZ, Roy S (1990) Metabolism of levonorgestrel, norethindrone, and structurally related contraceptive steroids. Contraception 42:67–96
Stanford JL, Brinton LA, Berman R, Mortel R, Twiggs LB, Barrett RJ, Wilbanks GD, Hoover RN (1993) Oral contraceptives and endometrial cancer: do other risk factors modify the association? Int J Cancer 54:243–248
Steingold KA, Cefalu W, Pardridge W, Judd HL, Chaudhuri G (1986) Enhanced hepatic extraction of estrogens used for replacement therapy. J Clin Endocrinol Metab 62:761–766
Szoka PR, Edgren RA (1988) Drμg interactions with oral contraceptives: compilation and analysis of an adverse experience report database. Fertil Steril (Suppl) 31–38
Taubert HD, Kuhl H (1995) Kontrazeption mit Hormonen, 2nd edn, Thieme, Stuttgart New York
van der Vange N, Blankenstein MA, Kloosterboer HJ, Haspels AA, Thijssen JHH (1990) Effects of seven low-dose combined oral contraceptives on sex hormone binding globulin, corticosteroid binding globulin, total and free testosterone. Contraception 41:345–352
Vessey MP, Lawless M, McPherson K, Yeates D (1985) Progestogen-only oral contraceptives. Findings in a large prospective study with special reference to effectiveness. Br J Family Plann 10:117–121
Vessey MP, Painter R (1994) Oral contraceptive use and benign gallbladder disease; revisited. Contraception 50:167–173
Vessey MP, Wright NH, McPherson K, Wiggins P (1978) Fertility after stopping different methods of contraception. Br Med J 1:265–267
Villard-Mackintosh L, Vessey MP (1993) Oral contraceptives and reproductive factors in multiple sclerosis incidence. Contraception 47:161–168
Vin F, Allaert FA, Levardon M (1992) Influence of estrogens and progesterone on the venous system of the lower limbs in women. Phlebology 18:888–892
Weir RJ, Davies DL, Fraser R, Morton JJ, Tree M, Wilson A (1975) Contraceptive steroids and hypertension. J Steroid Biochem 6:961–964
Whittemore AS, Harris R, Intyre J, and the Collaborative Ovarian Cancer Group (1992) Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. Am J Epidemiol 136:1l84–1203
Williams G, Anderson E, Howell A, Watson R, Coyne J, Roberts SA, Potten CS (1991) Oral contraceptive (OCP) use increases proliferation and decreases estrogen receptor content of epithelial cells in the normal human breast. Int J Cancer 48:206–210
Wingrave SJ (1982) Progestogen effects and their relationship to lipoprotein changes. Acta Obstet Gynecol Scand (Suppl) 33–36
World Health Organisation Collaborative Study of Neoplasia and Steroid Contraceptives (1985) Invasive cervical cancer and combined oral contraceptives. Br Med J 190:961–965
World Health Organisation Task Force for Epidemiological Research on Reproductive Health (1994a) Progestogen-only contraceptives during lactation: I. Infant growth. Contraception 50:35–53
World Health Organisation Task Force for Epidemiological Research on Reproductive Health (1994b) Progestogen-only contraceptives during lactation: II. Infant development. Contraception 50:55–68
World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception (1995) Effect of different progestagens in low estrogen oral contraceptives on venous thromboembolic disease. Lancet 346:1582–1588
World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid hormone Contraception (1996a) Ischaemic stroke and combined oral contraceptives: results of an international, multicentre, case-control study. Lancet 348:498–504
World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception (1996b) Haemorrhagic stroke, overall stroke risk, and combined oral contraceptives: results of an international, multicentre, case-control study Lancet 348:505–510
World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception (1997) Acute myocardial infarction and combined oral contraceptives: results of an international multi centre case-control study, Lancet 349:1202–1209
Wynn V (1982) Effect of duration of low-dose oral contraceptive administration on carbohydrate metabolism. Am J Obstet Gynecol 142:739–746
Yuzpe AA, Smith RP, Rademaker AW (1982)A multicentre clinical investigation employing ethinylestradiol combined with dl-norgestrel as a postcoital contraceptive agent,Fertil Steril 37:508–513
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Kuhl, H. (1999). Hormonal Contraception. In: Estrogens and Antiestrogens II. Handbook of Experimental Pharmacology, vol 135 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60107-1_18
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