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Sex Differences in Body Composition

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Part of the book series:Advances in Experimental Medicine and Biology ((AEMB,volume 1043))

Abstract

Body composition differs between men and women. Men have more lean mass, and women have more fat mass than men. Men are more likely to accumulate adipose tissue around the trunk and abdomen, whereas women usually accumulate adipose tissue around the hips and thighs. Less is known about sex differences in ectopic fat depots. Advances in imaging allow thenoninvasive assessment of abdominal and femorogluteal fat compartments, intramyocellular lipids, intrahepatic lipids, pericardial adipose tissue, and neck adipose tissue including brown adipose tissue and tongue adipose tissue. In this review, sex differences of regional adipose tissue, muscle mass, ectopic lipids, and brown adipose tissue and their effects on cardiometabolic risk will be discussed. In addition, novel imaging techniques to quantify these body composition compartmentsnoninvasively will be described.

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References

  • Abate, N., Burns, D., Peshock, R. M., Garg, A., & Grundy, S. M. (1994). Estimation of adipose tissue mass by magnetic resonance imaging: Validation against dissection in human cadavers.Journal of Lipid Research, 35, 1490–1496.

    CAS PubMed  Google Scholar 

  • Arnold, A. M., Psaty, B. M., Kuller, L. H., Burke, G. L., Manolio, T. A., Fried, L. P., Robbins, J. A., & Kronmal, R. A. (2005). Incidence of cardiovascular disease in older Americans: The cardiovascular health study.Journal of the American Geriatrics Society, 53, 211–218.

    Article PubMed  Google Scholar 

  • Au-Yong, I. T., Thorn, N., Ganatra, R., Perkins, A. C., & Symonds, M. E. (2009). Brown adipose tissue and seasonal variation in humans.Diabetes, 58, 2583–2587.

    Article CAS PubMed Central PubMed  Google Scholar 

  • Baker, A. R., Silva, N. F., Quinn, D. W., Harte, A. L., Pagano, D., Bonser, R. S., Kumar, S., & McTernan, P. G. (2006). Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease.Cardiovascular Diabetology, 5, 1.

    Article PubMed Central PubMed  Google Scholar 

  • Batsis, J. A., Mackenzie, T. A., Barre, L. K., Lopez-Jimenez, F., & Bartels, S. J. (2014). Sarcopenia, sarcopenic obesity and mortality in older adults: Results from the National Health and Nutrition Examination Survey III.European Journal of Clinical Nutrition, 68, 1001–1007.

    Article CAS PubMed  Google Scholar 

  • Beneke, R., Neuerburg, J., & Bohndorf, K. (1991). Muscle cross-section measurement by magnetic resonance imaging.European Journal of Applied Physiology and Occupational Physiology, 63, 424–429.

    Article CAS PubMed  Google Scholar 

  • Bjorntorp, P. (1985). Regional patterns of fat distribution.Annals of Internal Medicine, 103, 994–995.

    Article CAS PubMed  Google Scholar 

  • Bjorntorp, P. (1992). Metabolic abnormalities in visceral obesity.Annals of Medicine, 24, 3–5.

    Article CAS PubMed  Google Scholar 

  • Bjorntorp, P., & Rosmond, R. (1999). Visceral obesity and diabetes.Drugs, 58(Suppl 1), 13–18; discussion 75–82.

    Article CAS PubMed  Google Scholar 

  • Blake, G. M., & Fogelman, I. (2007). Role of dual-energy X-ray absorptiometry in the diagnosis and treatment of osteoporosis.Journal of Clinical Densitometry, 10, 102–110.

    Article PubMed  Google Scholar 

  • Boesch, C. (2007). Musculoskeletal spectroscopy.Journal of Magnetic Resonance Imaging, 25, 321–338.

    Article PubMed  Google Scholar 

  • Boesch, C., & Kreis, R. (2000). Observation of intramyocellular lipids by 1H-magnetic resonance spectroscopy.Annals of the New York Academy of Sciences, 904, 25–31.

    Article CAS PubMed  Google Scholar 

  • Boesch, C., Slotboom, J., Hoppeler, H., & Kreis, R. (1997). In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy.Magnetic Resonance in Medicine, 37, 484–493.

    Article CAS PubMed  Google Scholar 

  • Borkan, G. A., Hults, D. E., Gerzof, S. G., Robbins, A. H., & Silbert, C. K. (1983). Age changes in body composition revealed by computed tomography.Journal of Gerontology, 38, 673–677.

    Article CAS PubMed  Google Scholar 

  • Bredella, M. A., Utz, A. L., Torriani, M., Thomas, B., Schoenfeld, D. A., & Miller, K. K. (2009). Anthropometry, CT, and DXA as predictors of GH deficiency in premenopausal women: ROC curve analysis.Journal of Applied Physiology, 106, 418–422.

    Article CAS PubMed  Google Scholar 

  • Bredella, M. A., Ghomi, R. H., Thomas, B. J., Torriani, M., Brick, D. J., Gerweck, A. V., Misra, M., Klibanski, A., & Miller, K. K. (2010a). Comparison of DXA and CT in the assessment of body composition in premenopausal women with obesity and anorexia nervosa.Obesity (Silver Spring), 18, 2227–2233.

    Article  Google Scholar 

  • Bredella, M. A., Hosseini Ghomi, R., Thomas, B. J., Miller, K. K., & Torriani, M. (2010b). Comparison of 3.0 T proton magnetic resonance spectroscopy short and long echo-time measures of intramyocellular lipids in obese and normal-weight women.Journal of Magnetic Resonance Imaging, 32, 388–393.

    Article PubMed Central PubMed  Google Scholar 

  • Bredella, M. A., Hosseini Ghomi, R., Thomas, B. J., Ouellette, H. A., Sahani, D. V., Miller, K. K., & Torriani, M. (2010c). Breath-hold 1H-magnetic resonance spectroscopy for intrahepatic lipid quantification at 3 tesla.Journal of Computer Assisted Tomography, 34, 372–376.

    Article PubMed Central PubMed  Google Scholar 

  • Bredella, M. A., Gill, C. M., Keating, L. K., Torriani, M., Anderson, E. J., Punyanitya, M., Wilson, K. E., Kelly, T. L., & Miller, K. K. (2013). Assessment of abdominal fat compartments using DXA in premenopausal women from anorexia nervosa to morbid obesity.Obesity (Silver Spring), 21, 2458–2464.

    Article CAS  Google Scholar 

  • Brinkley, T. E., Hsu, F. C., Carr, J. J., Hundley, W. G., Bluemke, D. A., Polak, J. F., & Ding, J. (2011). Pericardial fat is associated with carotid stiffness in the multi-ethnic study of atherosclerosis.Nutrition, Metabolism, and Cardiovascular Diseases, 21, 332–338.

    Article CAS PubMed  Google Scholar 

  • Cannon, B., & Nedergaard, J. (2004). Brown adipose tissue: Function and physiological significance.Physiological Reviews, 84, 277–359.

    Article CAS PubMed  Google Scholar 

  • Charlton, M. (2008). Cirrhosis and liver failure in nonalcoholic fatty liver disease: Molehill or mountain?Hepatology, 47, 1431–1433.

    Article PubMed Central PubMed  Google Scholar 

  • Chen, K. Y., Cypess, A. M., Laughlin, M. R., Haft, C. R., Hu, H. H., Bredella, M. A., Enerback, S., Kinahan, P. E., Lichtenbelt, W., Lin, F. I., Sunderland, J. J., Virtanen, K. A., & Wahl, R. L. (2016). Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for standardized FDG-PET/CT experiments in humans.Cell Metabolism, 24, 210–222.

    Article CAS PubMed Central PubMed  Google Scholar 

  • Cheng, K. H., Chu, C. S., Lee, K. T., Lin, T. H., Hsieh, C. C., Chiu, C. C., Voon, W. C., Sheu, S. H., & Lai, W. T. (2008). Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease.International Journal of Obesity, 32, 268–274.

    Article CAS PubMed  Google Scholar 

  • Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y. H., Doria, A., Kolodny, G. M., & Kahn, C. R. (2009). Identification and importance of brown adipose tissue in adult humans.The New England Journal of Medicine, 360, 1509–1517.

    Article CAS PubMed Central PubMed  Google Scholar 

  • DeFronzo, R. A., & Tripathy, D. (2009). Skeletal muscle insulin resistance is the primary defect in type 2 diabetes.Diabetes Care, 32(Suppl 2), S157–S163.

    Article CAS PubMed Central PubMed  Google Scholar 

  • Dichtel, L. E., Eajazi, A., Miller, K. K., Torriani, M., & Bredella, M. A. (2016). Short- and long-term reproducibility of intrahepatic lipid quantification by 1H-MR spectroscopy and CT in obesity.Journal of Computer Assisted Tomography, 40, 678–682.

    Article PubMed Central PubMed  Google Scholar 

  • Ding, J., Kritchevsky, S. B., Hsu, F. C., Harris, T. B., Burke, G. L., Detrano, R. C., Szklo, M., Criqui, M. H., Allison, M., Ouyang, P., Brown, E. R., & Carr, J. J. (2008). Association between non-subcutaneous adiposity and calcified coronary plaque: A substudy of the Multi-Ethnic Study of Atherosclerosis.The American Journal of Clinical Nutrition, 88, 645–650.

    Article CAS PubMed Central PubMed  Google Scholar 

  • Engstrom, C. M., Loeb, G. E., Reid, J. G., Forrest, W. J., & Avruch, L. (1991). Morphometry of the human thigh muscles. A comparison between anatomical sections and computer tomographic and magnetic resonance images.Journal of Anatomy, 176, 139–156.

    CAS PubMed Central PubMed  Google Scholar 

  • Fantuzzi, G., & Mazzone, T. (2007). Adipose tissue and atherosclerosis: Exploring the connection.Arteriosclerosis, Thrombosis, and Vascular Biology, 27, 996–1003.

    Article CAS PubMed  Google Scholar 

  • Fox, C. S., Massaro, J. M., Hoffmann, U., Pou, K. M., Maurovich-Horvat, P., Liu, C. Y., Vasan, R. S., Murabito, J. M., Meigs, J. B., Cupples, L. A., D’Agostino, R. B., Sr., & O’Donnell, C. J. (2007). Abdominal visceral and subcutaneous adipose tissue compartments: Association with metabolic risk factors in the Framingham Heart Study.Circulation, 116, 39–48.

    Article PubMed  Google Scholar 

  • Friedman, D. J., Wang, N., Meigs, J. B., Hoffmann, U., Massaro, J. M., Fox, C. S., & Magnani, J. W. (2014). Pericardial fat is associated with atrial conduction: The Framingham Heart Study.Journal of the American Heart Association, 3, e000477.

    Article PubMed Central PubMed  Google Scholar 

  • Fuller, N. J., Hardingham, C. R., Graves, M., Screaton, N., Dixon, A. K., Ward, L. C., & Elia, M. (1999). Assessment of limb muscle and adipose tissue by dual-energy X-ray absorptiometry using magnetic resonance imaging for comparison.International Journal of Obesity and Related Metabolic Disorders, 23, 1295–1302.

    Article CAS PubMed  Google Scholar 

  • Gallagher, D., Visser, M., De Meersman, R. E., Sepulveda, D., Baumgartner, R. N., Pierson, R. N., Harris, T., & Heymsfield, S. B. (1985). 1997 Appendicular skeletal muscle mass: Effects of age, gender, and ethnicity.Journal of Applied Physiology, 83, 229–239.

    Article  Google Scholar 

  • Glickman, S. G., Marn, C. S., Supiano, M. A., & Dengel, D. R. (1985). 2004 Validity and reliability of dual-energy X-ray absorptiometry for the assessment of abdominal adiposity.Journal of Applied Physiology, 97, 509–514.

    Article  Google Scholar 

  • Godoy, I. R., Martinez-Salazar, E. L., Eajazi, A., Genta, P. R., Bredella, M. A., & Torriani, M. (2016). Fat accumulation in the tongue is associated with male gender, abnormal upper airway patency and whole-body adiposity.Metabolism, 65, 1657–1663.

    Article CAS PubMed Central PubMed  Google Scholar 

  • Goodpaster, B. H., Thaete, F. L., Simoneau, J. A., & Kelley, D. E. (1997). Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat.Diabetes, 46, 1579–1585.

    Article CAS PubMed  Google Scholar 

  • Goodpaster, B. H., Theriault, R., Watkins, S. C., & Kelley, D. E. (2000). Intramuscular lipid content is increased in obesity and decreased by weight loss.Metabolism, 49, 467–472.

    Article CAS PubMed  Google Scholar 

  • Janssen, I., Heymsfield, S. B., Wang, Z. M., & Ross, R. (1985). 2000 Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr.Journal of Applied Physiology, 89, 81–88.

    Article  Google Scholar 

  • Kanehisa, H., Ikegawa, S., Tsunoda, N., & Fukunaga, T. (1994). Cross-sectional areas of fat and muscle in limbs during growth and middle age.International Journal of Sports Medicine, 15, 420–425.

    Article CAS PubMed  Google Scholar 

  • Kim, A. M., Keenan, B. T., Jackson, N., Chan, E. L., Staley, B., Poptani, H., Torigian, D. A., Pack, A. I., & Schwab, R. J. (2014). Tongue fat and its relationship to obstructive sleep apnea.Sleep, 37, 1639–1648.

    Article PubMed Central PubMed  Google Scholar 

  • Kvist, H., Chowdhury, B., Grangard, U., Tylen, U., & Sjostrom, L. (1988). Total and visceral adipose-tissue volumes derived from measurements with computed tomography in adult men and women: Predictive equations.The American Journal of Clinical Nutrition, 48, 1351–1361.

    Article CAS PubMed  Google Scholar 

  • Larsen, B. A., Wassel, C. L., Kritchevsky, S. B., Strotmeyer, E. S., Criqui, M. H., Kanaya, A. M., Fried, L. F., Schwartz, A. V., Harris, T. B., & Ix, J. H. (2016). Association of muscle mass, area, and strength with incident diabetes in older adults: The health ABC study.The Journal of Clinical Endocrinology and Metabolism, 101, 1847–1855.

    Article PubMed Central PubMed  Google Scholar 

  • Lee, J. J., Yin, X., Hoffmann, U., Fox, C. S., & Benjamin, E. J. (2016). Relation of pericardial fat, intrathoracic fat, and abdominal visceral fat with incident atrial fibrillation (from the Framingham Heart Study).The American Journal of Cardiology, 118, 1486–1492.

    Article PubMed Central PubMed  Google Scholar 

  • Leenders, M., Verdijk, L. B., van der Hoeven, L., Adam, J. J., van Kranenburg, J., Nilwik, R., & van Loon, L. J. (2013). Patients with type 2 diabetes show a greater decline in muscle mass, muscle strength, and functional capacity with aging.Journal of the American Medical Directors Association, 14, 585–592.

    Article PubMed  Google Scholar 

  • Lemieux, S., Prud’homme, D., Bouchard, C., Tremblay, A., & Despres, J. P. (1993). Sex differences in the relation of visceral adipose tissue accumulation to total body fatness.The American Journal of Clinical Nutrition, 58, 463–467.

    Article CAS PubMed  Google Scholar 

  • Lemieux, S., Despres, J. P., Moorjani, S., Nadeau, A., Theriault, G., Prud’homme, D., Tremblay, A., Bouchard, C., & Lupien, P. J. (1994). Are gender differences in cardiovascular disease risk factors explained by the level of visceral adipose tissue?Diabetologia, 37, 757–764.

    Article CAS PubMed  Google Scholar 

  • Levine, J. A., Abboud, L., Barry, M., Reed, J. E., Sheedy, P. F., & Jensen, M. D. (1985). 2000 Measuring leg muscle and fat mass in humans: Comparison of CT and dual-energy X-ray absorptiometry.Journal of Applied Physiology, 88, 452–456.

    Article  Google Scholar 

  • Lonardo, A., & Trande, P. (2000). Are there any sex differences in fatty liver? A study of glucose metabolism and body fat distribution.Journal of Gastroenterology and Hepatology, 15, 775–782.

    Article CAS PubMed  Google Scholar 

  • Lopez, M., & Tena-Sempere, M. (2016). Estradiol and brown fat.Best Practice & Research. Clinical Endocrinology & Metabolism, 30, 527–536.

    Article CAS  Google Scholar 

  • Lowell, B. B., & Spiegelman, B. M. (2000). Towards a molecular understanding of adaptive thermogenesis.Nature, 404, 652–660.

    Article CAS PubMed  Google Scholar 

  • Machann, J., Haring, H., Schick, F., & Stumvoll, M. (2004). Intramyocellular lipids and insulin resistance.Diabetes, Obesity & Metabolism, 6, 239–248.

    Article CAS  Google Scholar 

  • Machann, J., Thamer, C., Schnoedt, B., Haap, M., Haring, H. U., Claussen, C. D., Stumvoll, M., Fritsche, A., & Schick, F. (2005a). Standardized assessment of whole body adipose tissue topography by MRI.Journal of Magnetic Resonance Imaging, 21, 455–462.

    Article PubMed  Google Scholar 

  • Machann, J., Thamer, C., Schnoedt, B., Stefan, N., Stumvoll, M., Haring, H. U., Claussen, C. D., Schick, F., & Fritsche, A. (2005b). Age and gender related effects on adipose tissue compartments of subjects with increased risk for type 2 diabetes: A whole body MRI/MRS study.Magma, 18, 128–137.

    Article CAS PubMed  Google Scholar 

  • Machann, J., Stefan, N., & Schick, F. (2008). (1)H MR spectroscopy of skeletal muscle, liver and bone marrow.European Journal of Radiology, 67, 275–284.

    Article PubMed  Google Scholar 

  • Micklesfield, L. K., Goedecke, J. H., Punyanitya, M., Wilson, K. E., & Kelly, T. L. (2012). Dual-energy X-ray performs as well as clinical computed tomography for the measurement of visceral fat.Obesity (Silver Spring), 20, 1109–1114.

    Article  Google Scholar 

  • Mitsiopoulos, N., Baumgartner, R. N., Heymsfield, S. B., Lyons, W., Gallagher, D., & Ross, R. (1985). 1998 Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography.Journal of Applied Physiology, 85, 115–122.

    Article  Google Scholar 

  • Nichols, J. H., Samy, B., Nasir, K., Fox, C. S., Schulze, P. C., Bamberg, F., & Hoffmann, U. (2008). Volumetric measurement of pericardial adipose tissue from contrast-enhanced coronary computed tomography angiography: A reproducibility study.Journal of Cardiovascular Computed Tomography, 2, 288–295.

    Article PubMed Central PubMed  Google Scholar 

  • North, K. E., Graff, M., Franceschini, N., Reiner, A. P., Feitosa, M. F., Carr, J. J., Gordon-Larsen, P., Wojczynski, M. K., & Borecki, I. B. (2012). Sex and race differences in the prevalence of fatty liver disease as measured by computed tomography liver attenuation in European American and African American participants of the NHLBI family heart study.European Journal of Gastroenterology & Hepatology, 24, 9–16.

    Article  Google Scholar 

  • Ochi, M., Kohara, K., Tabara, Y., Kido, T., Uetani, E., Ochi, N., Igase, M., & Miki, T. (2010). Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men.Atherosclerosis, 212, 327–332.

    Article CAS PubMed  Google Scholar 

  • Oh, C., Jho, S., No, J. K., & Kim, H. S. (2015). Body composition changes were related to nutrient intakes in elderly men but elderly women had a higher prevalence of sarcopenic obesity in a population of Korean adults.Nutrition Research, 35, 1–6.

    Article CAS PubMed  Google Scholar 

  • Ohlson, L. O., Larsson, B., Svardsudd, K., Welin, L., Eriksson, H., Wilhelmsen, L., Bjorntorp, P., & Tibblin, G. (1985). The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow-up of the participants in the study of men born in 1913.Diabetes, 34, 1055–1058.

    Article CAS PubMed  Google Scholar 

  • Ouellet, V., Routhier-Labadie, A., Bellemare, W., Lakhal-Chaieb, L., Turcotte, E., Carpentier, A. C., & Richard, D. (2011). Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans.The Journal of Clinical Endocrinology and Metabolism, 96, 192–199.

    Article CAS PubMed  Google Scholar 

  • Park, S. W., Goodpaster, B. H., Lee, J. S., Kuller, L. H., Boudreau, R., de Rekeneire, N., Harris, T. B., Kritchevsky, S., Tylavsky, F. A., Nevitt, M., Cho, Y. W., & Newman, A. B. (2009). Excessive loss of skeletal muscle mass in older adults with type 2 diabetes.Diabetes Care, 32, 1993–1997.

    Article PubMed Central PubMed  Google Scholar 

  • Pedersen, S. B., Bruun, J. M., Kristensen, K., & Richelsen, B. (2001). Regulation of UCP1, UCP2, and UCP3 mRNA expression in brown adipose tissue, white adipose tissue, and skeletal muscle in rats by estrogen.Biochemical and Biophysical Research Communications, 288, 191–197.

    Article CAS PubMed  Google Scholar 

  • Power, M. L., & Schulkin, J. (2008). Sex differences in fat storage, fat metabolism, and the health risks from obesity: Possible evolutionary origins.The British Journal of Nutrition, 99, 931–940.

    Article CAS PubMed  Google Scholar 

  • Preis, S. R., Massaro, J. M., Hoffmann, U., D'Agostino, R. B., Sr., Levy, D., Robins, S. J., Meigs, J. B., Vasan, R. S., O'Donnell, C. J., & Fox, C. S. (2010). Neck circumference as a novel measure of cardiometabolic risk: The Framingham Heart study.The Journal of Clinical Endocrinology and Metabolism, 95, 3701–3710.

    Article CAS PubMed Central PubMed  Google Scholar 

  • Rodriguez-Cuenca, S., Monjo, M., Frontera, M., Gianotti, M., Proenza, A. M., & Roca, P. (2007). Sex steroid receptor expression profile in brown adipose tissue. Effects of hormonal status.Cellular Physiology and Biochemistry, 20, 877–886.

    Article CAS PubMed  Google Scholar 

  • Rosito, G. A., Massaro, J. M., Hoffmann, U., Ruberg, F. L., Mahabadi, A. A., Vasan, R. S., O'Donnell, C. J., & Fox, C. S. (2008). Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: The Framingham Heart Study.Circulation, 117, 605–613.

    Article PubMed  Google Scholar 

  • Rossner, S., Bo, W. J., Hiltbrandt, E., Hinson, W., Karstaedt, N., Santago, P., Sobol, W. T., & Crouse, J. R. (1990). Adipose tissue determinations in cadavers – a comparison between cross-sectional planimetry and computed tomography.International Journal of Obesity, 14, 893–902.

    CAS PubMed  Google Scholar 

  • Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., Kawai, Y., & Tsujisaki, M. (2009). High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity.Diabetes, 58, 1526–1531.

    Article CAS PubMed Central PubMed  Google Scholar 

  • Sampath, S. C., Sampath, S. C., Bredella, M. A., Cypess, A. M., & Torriani, M. (2016). Imaging of brown adipose tissue: State of the art.Radiology, 280, 4–19.

    Article PubMed Central PubMed  Google Scholar 

  • Schlett, C. L., Ferencik, M., Kriegel, M. F., Bamberg, F., Ghoshhajra, B. B., Joshi, S. B., Nagurney, J. T., Fox, C. S., Truong, Q. A., & Hoffmann, U. (2012). Association of pericardial fat and coronary high-risk lesions as determined by cardiac CT.Atherosclerosis, 222, 129–134.

    Article CAS PubMed Central PubMed  Google Scholar 

  • Schwab, R. J., Gupta, K. B., Gefter, W. B., Metzger, L. J., Hoffman, E. A., & Pack, A. I. (1995). Upper airway and soft tissue anatomy in normal subjects and patients with sleep-disordered breathing. Significance of the lateral pharyngeal walls.American Journal of Respiratory and Critical Care Medicine, 152, 1673–1689.

    Article CAS PubMed  Google Scholar 

  • Shulman, G. I. (2000). Cellular mechanisms of insulin resistance.The Journal of Clinical Investigation, 106, 171–176.

    Article CAS PubMed Central PubMed  Google Scholar 

  • Shulman, G. I. (2014). Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease.The New England Journal of Medicine, 371, 1131–1141.

    Article PubMed  Google Scholar 

  • Snijder, M. B., Visser, M., Dekker, J. M., Goodpaster, B. H., Harris, T. B., Kritchevsky, S. B., De Rekeneire, N., Kanaya, A. M., Newman, A. B., Tylavsky, F. A., & Seidell, J. C. (2005). Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study.Diabetologia, 48, 301–308.

    Article CAS PubMed  Google Scholar 

  • Soliman, E. Z., Ding, J., Hsu, F. C., Carr, J. J., Polak, J. F., & Goff, D. C., Jr. (2010). Association between carotid intima-media thickness and pericardial fat in the Multi-Ethnic Study of Atherosclerosis (MESA).Journal of Stroke and Cerebrovascular Diseases, 19, 58–65.

    Article PubMed Central PubMed  Google Scholar 

  • Tanner, J. M., Hughes, P. C., & Whitehouse, R. H. (1981). Radiographically determined widths of bone muscle and fat in the upper arm and calf from age 3–18 years.Annals of Human Biology, 8, 495–517.

    Article CAS PubMed  Google Scholar 

  • Tchernof, A., & Despres, J. P. (2013). Pathophysiology of human visceral obesity: An update.Physiological Reviews, 93, 359–404.

    Article CAS PubMed  Google Scholar 

  • Thomas, M. A., Chung, H. K., & Middlekauff, H. (2005). Localized two-dimensional 1H magnetic resonance exchange spectroscopy: A preliminary evaluation in human muscle.Magnetic Resonance in Medicine, 53, 495–502.

    Article CAS PubMed  Google Scholar 

  • Thuzar, M., & Ho, K. K. (2016). Mechanisms in endocrinology: Brown adipose tissue in humans: Regulation and metabolic significance.European Journal of Endocrinology, 175, R11–R25.

    Article CAS PubMed  Google Scholar 

  • Torriani, M., Thomas, B. J., Halpern, E. F., Jensen, M. E., Rosenthal, D. I., & Palmer, W. E. (2005). Intramyocellular lipid quantification: Repeatability with 1H MR spectroscopy.Radiology, 236, 609–614.

    Article PubMed  Google Scholar 

  • Torriani, M., Thomas, B. J., Bredella, M. A., & Ouellette, H. (2007). Intramyocellular lipid quantification: Comparison between 3.0- and 1.5-T (1)H-MRS.Magnetic Resonance Imaging, 25, 1105–1111.

    Article CAS PubMed Central PubMed  Google Scholar 

  • Torriani, M., Gill, C. M., Daley, S., Oliveira, A. L., Azevedo, D. C., & Bredella, M. A. (2014). Compartmental neck fat accumulation and its relation to cardiovascular risk and metabolic syndrome.The American Journal of Clinical Nutrition, 100, 1244–1251.

    Article CAS PubMed  Google Scholar 

  • Velan, S. S., Durst, C., Lemieux, S. K., Raylman, R. R., Sridhar, R., Spencer, R. G., Hobbs, G. R., & Thomas, M. A. (2007a). Investigation of muscle lipid metabolism by localized one- and two-dimensional MRS techniques using a clinical 3T MRI/MRS scanner.Journal of Magnetic Resonance Imaging, 25, 192–199.

    Article PubMed  Google Scholar 

  • Velan, S. S., Ramamurthy, S., Ainala, S., Durst, C., Lemieux, S. K., Raylman, R. R., Spencer, R. G., & Thomas, M. A. (2007b). Implementation and validation of localized constant-time correlated spectroscopy (LCT-COSY) on a clinical 3T MRI scanner for investigation of muscle metabolism.Journal of Magnetic Resonance Imaging, 26, 410–417.

    Article PubMed  Google Scholar 

  • Velan, S. S., Said, N., Narasimhan, K., Papan, C., Bahu, A., Vargo, J. A., Raylman, R. R., Thomas, M. A., Rajendran, V. M., Spencer, R. G., & Alway, S. E. (2008). Gender differences in musculoskeletal lipid metabolism as assessed by localized two-dimensional correlation spectroscopy.Magnetic Resonance Insights, 2008, 1–6.

    PubMed Central PubMed  Google Scholar 

  • Vessby, B., Gustafsson, I. B., Tengblad, S., Boberg, M., & Andersson, A. (2002). Desaturation and elongation of Fatty acids and insulin action.Annals of the New York Academy of Sciences, 967, 183–195.

    Article CAS PubMed  Google Scholar 

  • Warensjo, E., Riserus, U., & Vessby, B. (2005). Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men.Diabetologia, 48, 1999–2005.

    Article CAS PubMed  Google Scholar 

  • Westerbacka, J., Corner, A., Tiikkainen, M., Tamminen, M., Vehkavaara, S., Hakkinen, A. M., Fredriksson, J., & Yki-Jarvinen, H. (2004). Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: Implications for sex differences in markers of cardiovascular risk.Diabetologia, 47, 1360–1369.

    Article CAS PubMed  Google Scholar 

  • Wheeler, G. L., Shi, R., Beck, S. R., Langefeld, C. D., Lenchik, L., Wagenknecht, L. E., Freedman, B. I., Rich, S. S., Bowden, D. W., Chen, M. Y., & Carr, J. J. (2005). Pericardial and visceral adipose tissues measured volumetrically with computed tomography are highly associated in type 2 diabetic families.Investigative Radiology, 40, 97–101.

    Article PubMed  Google Scholar 

  • Williams, C. D., Stengel, J., Asike, M. I., Torres, D. M., Shaw, J., Contreras, M., Landt, C. L., & Harrison, S. A. (2011). Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study.Gastroenterology, 140, 124–131.

    Article PubMed  Google Scholar 

  • Wree, A., Broderick, L., Canbay, A., Hoffman, H. M., & Feldstein, A. E. (2013). From NAFLD to NASH to cirrhosis-new insights into disease mechanisms.Nature Reviews. Gastroenterology & Hepatology, 10, 627–636.

    Article CAS  Google Scholar 

  • Yoneshiro, T., Aita, S., Matsushita, M., Okamatsu-Ogura, Y., Kameya, T., Kawai, Y., Miyagawa, M., Tsujisaki, M., & Saito, M. (2011). Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans.Obesity (Silver Spring), 19, 1755–1760.

    Article  Google Scholar 

  • Yudkin, J. S., Eringa, E., & Stehouwer, C. D. (2005). “Vasocrine” signalling from perivascular fat: A mechanism linking insulin resistance to vascular disease.Lancet, 365, 1817–1820.

    Article PubMed  Google Scholar 

  • Zhang, Z., Cypess, A. M., Miao, Q., Ye, H., Liew, C. W., Zhang, Q., Xue, R., Zhang, S., Zuo, C., Xu, Z., Tang, Q., Hu, R., Guan, Y., & Li, Y. (2014). The prevalence and predictors of active brown adipose tissue in Chinese adults.European Journal of Endocrinology, 170, 359–366.

    Article CAS PubMed Central PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Division of Musculoskeletal Radiology and Interventions, Massachusetts General Hospital, Boston, MA, USA

    Miriam A. Bredella

  2. Harvard Medical School, Boston, MA, USA

    Miriam A. Bredella

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  1. Miriam A. Bredella

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Correspondence toMiriam A. Bredella.

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  1. Department of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA

    Franck Mauvais-Jarvis

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Bredella, M.A. (2017). Sex Differences in Body Composition. In: Mauvais-Jarvis, F. (eds) Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity. Advances in Experimental Medicine and Biology, vol 1043. Springer, Cham. https://doi.org/10.1007/978-3-319-70178-3_2

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