1. World Health Organization, United Nations Children's Fund, International Council for the Control of Iodine Deficiency Disorders.Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination. A Guide for Programme Managers. 3rd ed. Geneva, Switzerland: World Health Organization; 2007.

   Google Scholar 

2. WHO Secretariat on behalf of the participants to the Consultation, Andersson M, de Benoist B, Delange F, Zupan J. Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: conclusions and recommendations of the Technical Consultation.Public Health Nutr. 2007;10:1606-1611.

   Google Scholar 

3. Bulow PI, Knudsen N, Jorgensen T, Perrild H, Ovesen L, Laurberg P. Large differences in incidences of overt hyper- and hypothyroidism associated with a small difference in iodine intake: a prospective comparative register-based population survey.J Clin Endocrinol Metab. 2002;87:4462-4469.

   Google Scholar 

4. Laurberg P, Bulow PI, Knudsen N, Ovesen L, Andersen S. Environmental iodine intake affects the type of nonmalignant thyroid disease.Thyroid. 2001;11:457-469.

   PubMed CAS  Google Scholar 

5. Laurberg P. Global or Gaelic epidemic of hypothyroidism?Lancet. 2005;365:738-740.

   PubMed  Google Scholar 

6. de Benoist B, McLean E, Andersson M, Rogers L. Iodine deficiency in 2007: global progress since 2003.Food Nutr Bull. 2008;29:195-202.

   PubMed  Google Scholar 

7. Delange FD, Dunn JT. Iodine deficiency. In: Braverman LE, Utiger RD, eds.The Thyroid: AFundamental and Clinical Text. 9th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005.

   Google Scholar 

8. Zimmermann MB, Jooste PL, Pandav CS. Iodine-deficiency disorders.Lancet. 2008;372(9645):1251-1262.

   PubMed CAS  Google Scholar 

9. Rousset BA, Dunn JT. Thyroid hormone synthesis and secretion. In: DeGroot LE, Hannemann G, eds.The Thyroid and Its Diseases, 2004. Internet: http://www.thyroidmanager.org/Chapter2/2-frame.htm. Accessed September 9, 2008.

   Google Scholar 

10. Eskandari S, Loo DD, Dai G, Levy O, Wright EM, Carrasco N. Thyroid Na+/I- symporter. Mechanism, stoichiometry, and specificity.J Biol Chem. 1997;272:27230-27238.

    PubMed CAS  Google Scholar 

11. Chopra IJ, Hershman JM, Hornabrook RW. Serum thyroid hormone and thyrotropin levels in subjects from endemic goiter regions of New Guinea.J Clin Endocrinol Metab. 1975;40:326-333.

    PubMed CAS  Google Scholar 

12. Delange F, Hershman JM, Ermans AM. Relationship between the serum thyrotropin level, the prevalence of goiter and the pattern of iodine metabolism in Idjwi Island.J Clin Endocrinol Metab. 1971;33:261-268.

    PubMed CAS  Google Scholar 

13. Vanderpas J. Nutritional epidemiology and thyroid hormone metabolism.Annu Rev Nutr. 2006;26:293-322.

    PubMed CAS  Google Scholar 

14. Stevenson C, Silva E, Pineda G. Thyroxine (T4) and triiodothyronine (T3): effects of iodine on the serum concentrations and disposal rates in subjects from an endemic goiter area.J Clin Endocrinol Metab. 1974;38:390-393.

    PubMed CAS  Google Scholar 

15. Chopra IJ, Sack J, Fisher DA. Circulating 3,3′,5′-triiodothyronine (reverse T3) in the human newborn.J Clin Invest. 1975;55:1137-1141.

    PubMed CAS  Google Scholar 

16. Patel YC, Pharoah PO, Hornabrook RW, Hetzel BS. Serum triiodothyronine, thyroxine and thyroid-stimulating hormone in endemic goiter: a comparison of goitrous and nongoitrous subjects in New Guinea.J Clin Endocrinol Metab. 1973;37:783-789.

    PubMed CAS  Google Scholar 

17. Pharaoh PO, Lawton NF, Ellis SM, Williams ES, Ekins RP. The role of triiodothyronine (T3) in the maintenance of euthyroidism in endemic goitre.Clin Endocrinol (Oxford). 1973;2:193-199.

    CAS  Google Scholar 

18. Ingenbleek Y, Luypaert B, De Nayer P. Nutritional status and endemic goitre.Lancet. 1980;1:388-391.

    PubMed CAS  Google Scholar 

19. Spencer CA, Wang CC. Thyroglobulin measurement. Techniques, clinical benefits, and pitfalls.Endocrinol Metab Clin North Am. 1995;24:841-863.

    PubMed CAS  Google Scholar 

20. Dunn JT, Dunn AD. Thyroglobulin: chemistry, biosynthesis and proteolysis. In: Braverman LE, Rutiger RD, eds.Werner and Ingbar’s the Thyroid: A Fundamental and Clinical Text. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2000.

    Google Scholar 

21. Van Herle AJ, Hershman JM, Hornabrook RW, Chopra IJ. Serum thyroglobulin in inhabitants of an endemic goiter region of New Guinea.J Clin Endocrinol Metab. 1976;43:512-516.

    PubMed  Google Scholar 

22. Pezzino V, Vigneri R, Squatrito S, Filetti S, Camus M, Polosa P. Increased serum thyroglobulin levels in patients with nontoxic goiter.J Clin Endocrinol Metab. 1978;46:653-657.

    PubMed CAS  Google Scholar 

23. Hershman JM, Due DT, Sharp B, et al. Endemic goiter in Vietnam.J Clin Endocrinol Metab. 1983;57:243-249.

    PubMed CAS  Google Scholar 

24. Fenzi GF, Ceccarelli C, Macchia E, et al. Reciprocal changes of serum thyroglobulin and TSH in residents of a moderate endemic goitre area.Clin Endocrinol (Oxford). 1985;23:115-122.

    CAS  Google Scholar 

25. van den Briel T, West CE, Hautvast JG, Vulsma T, de Vijlder JJ, Ategbo EA. Serum thyroglobulin and urinary iodine concentration are the most appropriate indicators of iodine status and thyroid function under conditions of increasing iodine supply in schoolchildren in Benin.J Nutr. 2001;131:2701-2706.

    PubMed  Google Scholar 

26. Zimmermann MB, Moretti D, Chaouki N, Torresani T. Development of a dried whole-blood spot thyroglobulin assay and its evaluation as an indicator of thyroid status in goitrous children receiving iodized salt.Am J Clin Nutr. 2003;77:1453-1458.

    PubMed CAS  Google Scholar 

27. Zimmermann MB, de Benoist B, Corigliano S, et al. Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient children.J Clin Endocrinol Metab. 2006;91:4881-4887.

    PubMed CAS  Google Scholar 

28. Hennemann G, Djokomoeljanto R, Docter R, et al. The relationship between serum protein-bound iodine levels and urinary iodine excretion and serum thyrotrophin concentrations in subjects from an endemic goitre area in central Java.Acta Endocrinol (Copenhagen). 1978;88:474-481.

    CAS  Google Scholar 

29. Dumont JE, Ermans AM, Maenhaut C, Coppee F, Stanbury JB. Large goitre as a maladaptation to iodine deficiency.Clin Endocrinol (Oxford). 1995;43:1-10.

    CAS  Google Scholar 

30. Dumont JE, Lamy F, Roger P, Maenhaut C. Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors.Physiol Rev. 1992;72:667-697.

    PubMed CAS  Google Scholar 

31. Aghini-Lombardi F, Antonangeli L, Martino E, et al. The spectrum of thyroid disorders in an iodine-deficient community: the Pescopagano survey.J Clin Endocrinol Metab. 1999;84:561-566.

    PubMed CAS  Google Scholar 

32. Knudsen N, Bulow I, Jorgensen T, Laurberg P, Ovesen L, Perrild H. Comparative study of thyroid function and types of thyroid dysfunction in two areas in Denmark with slightly different iodine status.Eur J Endocrinol. 2000;143:485-491.

    PubMed CAS  Google Scholar 

33. Laurberg P, Nohr SB, Pedersen KM, et al. Thyroid disorders in mild iodine deficiency.Thyroid. 2000;10:951-963.

    PubMed CAS  Google Scholar 

34. Valeix P, Dos Santos C, Castetbon K, Bertrais S, Cousty C, Hercberg S. Thyroid hormone levels and thyroid dysfunction of French adults participating in the SU.VI.MAX study.Ann Endocrinol (Paris). 2004;65:477-486.

    CAS  Google Scholar 

35. Valeix P, Zarebska M, Preziosi P, Galan P, Pelletier B, Hercberg S. Iodine deficiency in France.Lancet. 1999;353:1766-1767.

    PubMed CAS  Google Scholar 

36. Rasmussen LB, Ovesen L, Bulow I, et al. Dietary iodine intake and urinary iodine excretion in a Danish population: effect of geography, supplements and food choice.Br J Nutr. 2002;87:61-69.

    PubMed CAS  Google Scholar 

37. Thomson CD, Woodruffe S, Colls AJ, Joseph J, Doyle TC. Urinary iodine and thyroid status of New Zealand residents.Eur J Clin Nutr. 2001;55:387-392.

    PubMed CAS  Google Scholar 

38. Lazarus JH, Parkes AB, John R, N'Diaye M, Prysor-Jones SG. Endemic goitre in Senegal—thyroid function etiological factors and treatment with oral iodized oil.Acta Endocrinol (Copenhagen). 1992;126:149-154.

    CAS  Google Scholar 

39. Buttfield IH, Black ML, Hoffmann MJ, et al. Studies of the control of thyroid function in endemic goiter in Eastern New Guinea.J Clin Endocrinol Metab. 1966;26:1201-1207.

    PubMed CAS  Google Scholar 

40. Delange F. The disorders induced by iodine deficiency.Thyroid. 1994;4:107-128.

    PubMed CAS  Google Scholar 

41. Andersen S, Pedersen KM, Pedersen IB, Laurberg P. Variations in urinary iodine excretion and thyroid function. A 1-year study in healthy men.Eur J Endocrinol. 2001;144:461-465.

    PubMed CAS  Google Scholar 

42. Soldin OP, Tractenberg RE, Pezzullo JC. Do thyroxine and thyroid-stimulating hormone levels reflect urinary iodine concentrations?Ther Drug Monit. 2005;27:178-185.

    PubMed CAS  Google Scholar 

43. Aboul-Khair SA, Crooks J, Turnbull AC, Hytten FE. The physiological changes in thyroid function during pregnancy.Clin Sci. 1964;27:195-207.

    PubMed CAS  Google Scholar 

44. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology.Endocr Rev. 1997;18:404-433.

    PubMed CAS  Google Scholar 

45. Liberman CS, Pino SC, Fang SL, Braverman LE, Emerson CH. Circulating iodide concentrations during and after pregnancy.J Clin Endocrinol Metab. 1998;83:3545-3549.

    PubMed CAS  Google Scholar 

46. Lazarus JH. Epidemiology and prevention of thyroid disease in pregnancy.Thyroid. 2002;12:861-865.

    PubMed  Google Scholar 

47. Glinoer D. The importance of iodine nutrition during pregnancy.Public Health Nutr. 2007;10:1542-1546.

    PubMed  Google Scholar 

48. Caron P, Hoff M, Bazzi S, et al. Urinary iodine excretion during normal pregnancy in healthy women living in the southwest of France: correlation with maternal thyroid parameters.Thyroid. 1997;7:749-754.

    PubMed CAS  Google Scholar 

49. Kung AW, Lao TT, Chau MT, Tam SC, Low LC. Goitrogenesis during pregnancy and neonatal hypothyroxinaemia in a borderline iodine sufficient area.Clin Endocrinol (Oxford). 2000;53:725-731.

    CAS  Google Scholar 

50. Nohr SB, Laurberg P, Borlum KG, et al. Iodine deficiency in pregnancy in Denmark. Regional variations and frequency of individual iodine supplementation.Acta Obstet Gynecol Scand. 1993;72:350-353.

    PubMed CAS  Google Scholar 

51. Vermiglio F, Lo Presti VP, Castagna MG, et al. Increased risk of maternal thyroid failure with pregnancy progression in an iodine deficient area with major iodine deficiency disorders.Thyroid. 1999;9:19-24.

    PubMed CAS  Google Scholar 

52. Lazarus JH. Comments.Public Health Nutr. 2007;10:1553.

    Google Scholar 

53. Pedersen KM, Laurberg P, Iversen E, et al. Amelioration of some pregnancy-associated variations in thyroid function by iodine supplementation.J Clin Endocrinol Metab. 1993;77:1078-1083.

    PubMed CAS  Google Scholar 

54. Zimmermann MB. The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: a review.Thyroid. 2007;17:829-835.

    Google Scholar 

55. Romano R, Jannini EA, Pepe M, et al. The effects of iodoprophylaxis on thyroid size during pregnancy.Am J Obstet Gynecol. 1991;164:482-485.

    PubMed CAS  Google Scholar 

56. Glinoer D, De Nayer P, Delange F, et al. A randomized trial for the treatment of mild iodine deficiency during pregnancy: maternal and neonatal effects.J Clin Endocrinol Metab. 1995;80:258-269.

    PubMed CAS  Google Scholar 

57. Liesenkotter KP, Gopel W, Bogner U, Stach B, Gruters A. Earliest prevention of endemic goiter by iodine supplementation during pregnancy.Eur J Endocrinol. 1996;134:443-448.

    PubMed CAS  Google Scholar 

58. Nohr SB, Jorgensen A, Pedersen KM, Laurberg P. Postpartum thyroid dysfunction in pregnant thyroid peroxidase antibody-positive women living in an area with mild to moderate iodine deficiency: is iodine supplementation safe?J Clin Endocrinol Metab. 2000;85:3191-3198.

    PubMed CAS  Google Scholar 

59. Antonangeli L, Maccherini D, Cavaliere R, et al. Comparison of two different doses of iodide in the prevention of gestational goiter in marginal iodine deficiency: a longitudinal study.Eur J Endocrinol. 2002;147:29-34.

    PubMed CAS  Google Scholar 

60. Pharoah PO, Connolly KJ. A controlled trial of iodinated oil for the prevention of endemic cretinism: a long-term follow-up.Int J Epidemiol. 1987;16:68-73.

    PubMed CAS  Google Scholar 

61. Cao XY, Jiang XM, Dou ZH, et al. Timing of vulnerability of the brain to iodine deficiency in endemic cretinism.N Engl J Med. 1994;331:1739-1744.

    PubMed CAS  Google Scholar 

62. Connolly KJ, Pharoah PO, Hetzel BS. Fetal iodine deficiency and motor performance during childhood.Lancet. 1979;2:1149-1151.

    PubMed CAS  Google Scholar 

63. Moleti M, Lo Presti VP, Campolo MC, et al. Iodine prophylaxis using iodized salt and risk of maternal thyroid failure in conditions of mild iodine deficiency.J Clin Endocrinol Metab. 2008;93:2616-2621.

    PubMed CAS  Google Scholar 

64. Weeke J, Dybkjaer L, Granlie K, et al. A longitudinal study of serum TSH, and total and free iodothyronines during normal pregnancy.Acta Endocrinol (Copenhagen). 1982;101:531-537.

    CAS  Google Scholar 

65. Glinoer D. Maternal and fetal impact of chronic iodine deficiency.Clin Obstet Gynecol. 1997;40:102-116.

    PubMed CAS  Google Scholar 

66. Laurberg P, Andersen S, Bjarnadottir RI, et al. Evaluating iodine deficiency in pregnant women and young infants-complex physiology with a risk of misinterpretation.Public Health Nutr. 2007;10:1547-1552.

    PubMed CAS  Google Scholar 

67. Delange F. Screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control.Thyroid. 1998;8:1185-1192.

    PubMed CAS  Google Scholar 

68. Glinoer D, Delange F, Laboureur I, et al. Maternal and neonatal thyroid function at birth in an area of marginally low iodine intake.J Clin Endocrinol Metab. 1992;75:800-805.

    PubMed CAS  Google Scholar 

69. Delange F. Iodine requirements during pregnancy, lactation and the neonatal period and indicators of optimal iodine nutrition.Public Health Nutr. 2007;10:1571-1580.

    PubMed  Google Scholar 

70. Sullivan KM, May W, Nordenberg D, Houston R, Maberly GF. Use of thyroid stimulating hormone testing in newborns to identify iodine deficiency.J Nutr. 1997;127:55-58.

    PubMed CAS  Google Scholar 

71. Delange F. Neonatal screening for congenital hypothyroidism: results and perspectives.Horm Res. 1997;48:51-61.

    PubMed CAS  Google Scholar 

72. Zimmermann MB, Aeberli I, Torresani T, Burgi H. Increasing the iodine concentration in the Swiss iodized salt program markedly improved iodine status in pregnant women and children: a 5-y prospective national study.Am J Clin Nutr. 2005;82:388-392.

    PubMed CAS  Google Scholar 

73. Zimmermann MB. Methods to assess iron and iodine status.Br J Nutr. 2008;99(suppl 3):S2-S9.

    PubMed CAS  Google Scholar 

74. Sava L, Delange F, Belfiore A, Purrello F, Vigneri R. Transient impairment of thyroid function in newborn from an area of endemic goiter.J Clin Endocrinol Metab. 1984;59:90-95.

    PubMed CAS  Google Scholar 

75. Nordenberg D, Sullivan K, Maberly G, et al. Congenital hypothyroid screening programs and the sensitive thyrotropin assay: strategies for the surveillance of iodine deficiency disorders. In: Delange F, Dunn J, Glinoer D, eds.Iodine Deficiency in Europe: A Continuing Concern. New York, NY: Plenum Publishing; 1993:211-217.

    Google Scholar 

76. McElduff A, McElduff P, Gunton JE, Hams G, Wiley V, Wilcken BM. Neonatal thyroid-stimulating hormone concentrations in northern Sydney: further indications of mild iodine deficiency?Med J Aust. 2002;176:317-320.

    PubMed  Google Scholar 

77. Travers CA, Guttikonda K, Norton CA, et al. Iodine status in pregnant women and their newborns: are our babies at risk of iodine deficiency?Med J Aust. 2006;184:617-620.

    PubMed  Google Scholar 

78. Veinpalu M, Ambos A, Velbri S, Vaher Y, Podar T. Urinary iodine excretion in Estonian children.Eur J Endocrinol. 1996;135:248.

    PubMed CAS  Google Scholar 

79. Mikelsaar RV, Viikmaa M. Neonatal thyroid-stimulating hormone screening as an indirect method for the assessment of iodine deficiency in Estonia.Horm Res. 1999;52:284-286.

    PubMed CAS  Google Scholar 

80. Guibourdenche J, Noel M, Chevenne D, et al. Biochemical investigation of foetal and neonatal thyroid function using the ACS-180SE analyser: clinical application.Ann Clin Biochem. 2001;38:520-526.

    PubMed CAS  Google Scholar 

81. Kung AW, Lao TT, Low LC, Pang RW, Robinson JD. Iodine insufficiency and neonatal hyperthyrotropinaemia in Hong Kong.Clin Endocrinol (Oxford). 1997;46:315-319.

    CAS  Google Scholar 

82. Chakraborty I, Chatterjee S, Bhadra D, Mukhopadhyaya BB, Dasgupta A, Purkait B. Iodine deficiency disorders among the pregnant women in a rural hospital of West Bengal.Indian J Med Res. 2006;123:825-829.

    PubMed CAS  Google Scholar 

83. Copeland DL, Sullivan KM, Houston R, et al. Comparison of neonatal thyroid-stimulating hormone levels and indicators of iodine deficiency in school children. Public Health Nutr. 2002;5:81-87.

    PubMed  Google Scholar 

84. Delange F, Thilly C, Camus M, et al. Evidence for fetal hhypothyroidism and maternal thyroid status in severe endemic goiter. In: Robbins J, Braverman LE, eds.Thyroid Research. Amsterdam, The Netherlands: Excerpta Medica; 1976:493-496.

    Google Scholar 

85. Thilly CH, Delange F, Lagasse R, et al. Fetal hypothyroidism and maternal thyroid status in severe endemic goiter.J Clin Endocrinol Metab. 1978;47:354-360.

    PubMed CAS  Google Scholar 

86. Delange F, Thilly C, Bourdoux P, et al. Influence of dietary goitroogens during pregnancy in humans on thyroid function of newborn. In: Delange F, Iteke FB, Ermans AM, eds.Nutritional Factors Involved in the Goitrogenic Action of Cassava. Ottawa, Canada: International Development Research Centre; 1982:40-50.

    Google Scholar 

87. Burrow GN, Fisher DA, Larsen PR. Maternal and fetal thyroid function.N Engl J Med. 1994;331:1072-1078.

    PubMed CAS  Google Scholar 

88. Eltom A, Eltom M, Idris M, Gebre-Medhin M. Thyroid function in the newborn in relation to maternal thyroid status during labour in a mild iodine deficiency endemic area in Sudan.Clin Endocrinol (Oxford). 2001;55:485-490.

    CAS  Google Scholar 

89. Morreale de Escobar G, Obregon MJ, Escobar del Rey F. Role of thyroid hormone during early brain development.Eur J Endocrinol. 2004;151(suppl 3):U25-U37.

    Google Scholar 

90. Nohr SB, Laurberg P. Opposite variations in maternal and neonatal thyroid function induced by iodine supplementation during pregnancy.J Clin Endocrinol Metab. 2000;85:623-627.

    PubMed CAS  Google Scholar 

91. Gruneiro-Papendieck L, Chiesa A, Mendez V, Bengolea S, Prieto L. Neonatal TSH levels as an index of iodine sufficiency: differences related to time of screening sampling and methodology.Horm Res. 2004;62:272-276.

    PubMed CAS  Google Scholar 

92. Benmiloud M, Chaouki ML, Gutekunst R, Teichert HM, Wood WG, Dunn JT. Oral iodized oil for correcting iodine deficiency: optimal dosing and outcome indicator selection.J Clin Endocrinol Metab. 1994;79:20-24.

    PubMed CAS  Google Scholar 

93. Pardede LV, Hardjowasito W, Gross R, et al. Urinary iodine excretion is the most appropriate outcome indicator for iodine deficiency at field conditions at district level.J Nutr. 1998;128:1122-1126.

    PubMed CAS  Google Scholar 

94. Zimmermann M, Adou P, Torresani T, Zeder C, Hurrell R. Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in Cote d'Ivoire.Am J Clin Nutr. 2000;71:88-93.

    PubMed CAS  Google Scholar 

95. Zimmermann MB, Jooste PL, Mabapa NS, et al. Treatment of iodine deficiency in school-age children increases insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations and improves somatic growth.J Clin Endocrinol Metab. 2007;92:437-442.

    PubMed CAS  Google Scholar 

96. Zimmermann MB, Jooste PL, Mabapa NS, et al. Vitamin A supplementation in iodine-deficient African children decreases thyrotropin stimulation of the thyroid and reduces the goiter rate.Am J Clin Nutr. 2007;86:1040-1044.

    PubMed CAS  Google Scholar 

97. Santiago-Fernandez P, Torres-Barahona R, Muela-Martinez JA, et al. Intelligence quotient and iodine intake: a cross-sectional study in children.J Clin Endocrinol Metab. 2004;89:3851-3857.

    PubMed CAS  Google Scholar 

98. Martino E, Loviselli A, Velluzzi F, et al. Endemic goiter and thyroid function in central-southern Sardinia. Report on an extensive epidemiological survey.J Endocrinol Invest. 1994;17:653-657.

    PubMed CAS  Google Scholar 

99. Dodd NS, Samuel AM. Iodine deficiency in adolescents from Bombay slums.Natl Med J India. 1993;6:110-113.

    PubMed CAS  Google Scholar 

100. Oberlin O, Plantin-Carrenard E, Rigal O, Wilkinson C. Goitre and iodine deficiency in Afghanistan: a case-control study.Br J Nutr. 2006;95:196-203.

     PubMed CAS  Google Scholar 

101. Tsatsoulis A, Johnson EO, Andricula M, et al. Thyroid autoimmunity is associated with higher urinary iodine concentrations in an iodine-deficient area of Northwestern Greece.Thyroid. 1999;9:279-283.

     PubMed CAS  Google Scholar 

102. Vanderpas J, Bourdoux P, Lagasse R, et al. Endemic infantile hypothyroidism in a severe endemic goitre area of central Africa.Clin Endocrinol (Oxford). 1984;20:327-340.

     CAS  Google Scholar 

103. Moreno-Reyes R, Boelaert M, el Badawi S, Eltom M, Vanderpas JB. Endemic juvenile hypothyroidism in a severe endemic goitre area of Sudan.Clin Endocrinol (Oxford). 1993;38:19-24.

     CAS  Google Scholar 

104. Zimmermann MB, Connolly K, Bozo M, Bridson J, Rohner F, Grimci L. Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study.Am J Clin Nutr. 2006;83:108-114.

     PubMed CAS  Google Scholar 

105. Mirmiran P, Kimiagar M, Azizi F. Three-year survey of effects of iodized oil injection in schoolchildren with iodine deficiency disorders.Exp Clin Endocrinol Diabetes. 2002;110:393-397.

     PubMed CAS  Google Scholar 

106. Zimmermann MB, Wegmuller R, Zeder C, Torresani T, Chaouki N. Rapid relapse of thyroid dysfunction and goiter in school-age children after discontinuation of salt iodization.Am J Clin Nutr. 2004;79:642-645.

     PubMed CAS  Google Scholar 

107. Bourdoux P, Ermans AM. Factors influencing the levels of circulating T4, T3 and TSH in human beings submitted to severe iodine deficiency.Ann Endocrinol (Paris). 1981;42:40A

     Google Scholar 

108. Bachtarzi H, Benmiloud M. TSH-regulation and goitrogenesis in severe iodine deficiency.Acta Endocrinol (Copenhagen). 1983;103:21-27.

     CAS  Google Scholar 

109. Malvaux P. Thyroid function during the neonatal period, infancy and childhood. In: Delange F, Fisher DA, Malvaux P, eds.Pediatric Thyroidology. Basel, Switzerland: S. Karger AG; 1985:33-43.

     Google Scholar 

110. Delange F. Adaptation to iodine deficiency during growth: etiopathogenesis of endemic goiter abd cretinism. In: Delange F, Fisher AG, Glinoer D, eds.Pediatric Thyrology. Basel, Switzerland: S. Karger AG; 1985:295-326.

     Google Scholar 

111. Delange F, de Benoist B, Pretell E, Dunn JT. Iodine deficiency in the world: where do we stand at the turn of the century?Thyroid. 2001;11:437-447.

     PubMed CAS  Google Scholar 

112. Suzuki H, Higuchi T, Sawa K, Ohtaki S, Horiuchi Y. "Endemic coast goitre" in Hokkaido, Japan.Acta Endocrinol (Copenhagen). 1965;50:161-176.

     CAS  Google Scholar 

113. Nagataki S. The average of dietary iodine intake due to the ingestion of seaweeds is 1.2 mg/day in Japan.Thyroid. 2008;18:667-668.

     PubMed  Google Scholar 

114. Li M, Liu DR, Qu CY, et al. Endemic goitre in central China caused by excessive iodine intake.Lancet. 1987;2:257-259.

     PubMed CAS  Google Scholar 

115. Zhao J, Chen Z, Maberly G. Iodine-rich drinking water of natural origin in China.Lancet. 1998;352:2024.

     PubMed CAS  Google Scholar 

116. Sigurdsson G, Franzson L. Urine excretion of iodine in an Icelandic population.Icelandic Med J. 1988;74:179-181.

     Google Scholar 

117. Caldwell KL, Miller GA, Wang RY, Jain RB, Jones RL. Iodine status of the U.S. population, National Health and Nutrition Examination Survey 2003–2004.Thyroid. 2008;18:1207-1214.

     Google Scholar 

118. London WT, Vought RL, Brown FA. Bread—dietary source of large quantities of iodine.N Engl J Med. 1965;273:381.

     Google Scholar 

119. Pearce EN, Pino S, He X, Bazrafshan HR, Lee SL, Braverman LE. Sources of dietary iodine: bread, cows' milk, and infant formula in the Boston area.J Clin Endocrinol Metab. 2004;89:3421-3424.

     PubMed CAS  Google Scholar 

120. Scientific Committee on Food, Health and Consumer Protection Directorate-General.Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of Iodine. Brussels, Belgium: European Commission; 2002.

     Google Scholar 

121. Institute of Medicine, Academy of Sciences, USA.Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Washington, DC: National Academy Press; 2001.

     Google Scholar 

122. Chow CC, Phillips DI, Lazarus JH, Parkes AB. Effect of low dose iodide supplementation on thyroid function in potentially susceptible subjects: are dietary iodide levels in Britain acceptable?Clin Endocrinol (Oxford). 1991;34:413-416.

     CAS  Google Scholar 

123. Gardner DF, Centor RM, Utiger RD. Effects of low dose oral iodide supplementation on thyroid function in normal men.Clin Endocrinol (Oxford). 1988;28:283-288.

     CAS  Google Scholar 

124. Laurberg P, Pedersen KM, Hreidarsson A, Sigfusson N, Iversen E, Knudsen PR. Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark.J Clin Endocrinol Metab. 1998;83:765-769.

     PubMed CAS  Google Scholar 

125. Seck T, Scheidt-Nave C, Ziegler R, Pfeilschifter J. Prevalence of thyroid gland dysfunctions in 50- to 80-year-old patients. An epidemiologic cross-sectional study in a southwestern community.Med Klin (Munich). 1997;92:642-646.

     CAS  Google Scholar 

126. Hintze G, Burghardt U, Baumert J, Windeler J, Kobberling J. Prevalence of thyroid dysfunction in elderly subjects from the general population in an iodine deficiency area.Aging (Milano). 1991;3:325-331.

     CAS  Google Scholar 

127. Hintze G, Windeler J, Baumert J, Stein H, Kobberling J. Thyroid volume and goitre prevalence in the elderly as determined by ultrasound and their relationships to laboratory indices.Acta Endocrinol (Copenhagen). 1991;124:12-18.

     CAS  Google Scholar 

128. Szabolcs I, Podoba J, Feldkamp J, et al. Comparative screening for thyroid disorders in old age in areas of iodine deficiency, long-term iodine prophylaxis and abundant iodine intake.Clin Endocrinol (Oxford). 1997;47:87-92.

     CAS  Google Scholar 

129. Konno N, Makita H, Yuri K, Iizuka N, Kawasaki K. Association between dietary iodine intake and prevalence of subclinical hypothyroidism in the coastal regions of Japan.J Clin Endocrinol Metab. 1994;78:393-397.

     PubMed CAS  Google Scholar 

130. Roti E, Gardini E, Minelli R, Bianconi L, Braverman LE. Prevalence of anti-thyroid peroxidase antibodies in serum in the elderly: comparison with other tests for anti-thyroid antibodies.Clin Chem. 1992;38:88-92.

     PubMed CAS  Google Scholar 

131. Ozbakir O, Dogukan A, Kelestimur F. The prevalence of thyroid dysfunction among elderly subjects in an endemic goiter area of Central Anatolia.Endocr J. 1995;42:713-716.

     PubMed CAS  Google Scholar 

132. Nygaard B, Gideon P, Dige-Petersen H, Jespersen N, Solling K, Veje A. Thyroid volume and morphology and urinary iodine excretion in a Danish municipality.Acta Endocrinol (Copenhagen). 1993;129:505-510.

     CAS  Google Scholar 

133. Knudsen N, Jorgensen T, Rasmussen S, Christiansen E, Perrild H. The prevalence of thyroid dysfunction in a population with borderline iodine deficiency.Clin Endocrinol (Oxford). 1999;51:361-367.

     CAS  Google Scholar 

134. Knudsen N, Bulow I, Jorgensen T, Laurberg P, Ovesen L, Perrild H. Goitre prevalence and thyroid abnormalities at ultrasonography: a comparative epidemiological study in two regions with slightly different iodine status.Clin Endocrinol (Oxford). 2000;53:479-485.

     CAS  Google Scholar 

135. Tunbridge WM, Evered DC, Hall R, et al. The spectrum of thyroid disease in a community: the Whickham survey.Clin Endocrinol (Oxford). 1977;7:481-493.

     CAS  Google Scholar 

136. Petersen K, Lindstedt G, Lundberg PA, Bengtsson C, Lapidus L, Nystrom E. Thyroid disease in middle-aged and elderly Swedish women: thyroid-related hormones, thyroid dysfunction and goitre in relation to age and smoking.J Intern Med. 1991;229:407-413.

     PubMed CAS  Google Scholar 

137. Tajiri J, Higashi K, Morita M, Umeda T, Sato T. Studies of hypothyroidism in patients with high iodine intake.J Clin Endocrinol Metab. 1986;63:412-417.

     PubMed CAS  Google Scholar 

138. Sato K, Okamura K, Hirata T, et al. Immunological and chemical types of reversible hypothyroidism; clinical characteristics and long-term prognosis.Clin Endocrinol (Oxford). 1996;45:519-528.

     CAS  Google Scholar 

139. Sundick RS, Bagchi N, Brown TR. The role of iodine in thyroid autoimmunity: from chickens to humans: a review.Autoimmunity. 1992;13:61-68.

     PubMed CAS  Google Scholar 

140. Safran M, Paul TL, Roti E, Braverman LE. Environmental factors affecting autoimmune thyroid disease.Endocrinol Metab Clin North Am. 1987;16:327-342.

     PubMed CAS  Google Scholar 

141. Harach HR, Escalante DA, Onativia A, Lederer Outes J, Saravia Day E, Williams ED. Thyroid carcinoma and thyroiditis in an endemic goitre region before and after iodine prophylaxis.Acta Endocrinol (Copenhagen). 1985;108:55-60.

     CAS  Google Scholar 

142. Zimmermann MB, Ito Y, Hess SY, Fujieda K, Molinari L. High thyroid volume in children with excess dietary iodine intakes.Am J Clin Nutr. 2005;81:840-844.

     PubMed CAS  Google Scholar 

143. Roti E, Uberti ED. Iodine excess and hyperthyroidism.Thyroid. 2001;11:493-500.

     PubMed CAS  Google Scholar 

144. Elnagar B, Eltom M, Karlsson FA, Ermans AM, Gebre-Medhin M, Bourdoux PP. The effects of different doses of oral iodized oil on goiter size, urinary iodine, and thyroid-related hormones.J Clin Endocrinol Metab. 1995;80:891-897.

     PubMed CAS  Google Scholar 

145. Ermans AM, Gullo D, Mugisho SG, et al. Iodine supplementation must be monitored at the population level in iodine deficient areas [abstract].Thyroid. 1995;5(suppl 1):S137.

     Google Scholar 

146. Bourdoux PP, Ermans AM, Mukalay wa Mukalay A, Filetti S, Vigneri R. Iodine-induced thyrotoxicosis in Kivu, Zaire.Lancet. 1996;347:552-553.

     PubMed CAS  Google Scholar 

147. Todd CH, Allain T, Gomo ZA, Hasler JA, Ndiweni M, Oken E. Increase in thyrotoxicosis associated with iodine supplements in Zimbabwe.Lancet. 1995;346:1563-1564.

     PubMed CAS  Google Scholar 

148. Delange F, de Benoist B, Alnwick D. Risks of iodine-induced hyperthyroidism after correction of iodine deficiency by iodized salt.Thyroid. 1999;9:545-556.

     PubMed CAS  Google Scholar 

149. Burgi H, Kohler M, Morselli B. Thyrotoxicosis incidence in Switzerland and benefit of improved iodine supply.Lancet. 1998;352:1034.

     PubMed CAS  Google Scholar 

150. Yang F, Shan Z, Teng X, et al. Chronic iodine excess does not increase the incidence of hyperthyroidism: a prospective community-based epidemiological survey in China.Eur J Endocrinol. 2007;156:403-408.

     PubMed CAS  Google Scholar 

151. Teng W, Shan Z, Teng X, et al. Effect of iodine intake on thyroid diseases in China.N Engl J Med. 2006;354:2783-2793.

     PubMed CAS  Google Scholar 

152. Pedersen IB, Laurberg P, Knudsen N, et al. An increased incidence of overt hypothyroidism after iodine fortification of salt in Denmark: a prospective population study.J Clin Endocrinol Metab. 2007;92:3122-3127.

     PubMed CAS  Google Scholar 

153. Bulow PI, Laurberg P, Knudsen N, et al. Increase in incidence of hyperthyroidism predominantly occurs in young people after iodine fortification of salt in Denmark.J Clin Endocrinol Metab. 2006;91:3830-3834.

     Google Scholar 

154. Zimmermann MB. Iodine requirements and the risks and benefits of correcting iodine deficiency in populations.J Trace Elem Med Biol. 2008;22:81-92.

     PubMed CAS  Google Scholar 

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