Part of the book series:Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 165))
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Abstract
There are many reviews of pancreatic acinar cell function and also of pancreatic duct function, but there is an almost total absence of synthetic reviews bringing the integrated functions of these two vitally and mutually interdependent cells together. This is what we have attempted to do in this chapter. In the first part, we review the normal integrated function of the acinar-ductal system, with particular emphasis on how regulation of one type of cell also influences the other cell type. In the second part, we review a range of pathological processes, particularly those involved in acute pancreatitis (AP), an often-fatal human disease in which the pancreas digests itself, in order to explore how malfunction of one of the cell types adversely affects the function of the other.
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Abbreviations
- ACh:
Acetylcholine
- ASICs:
Acid-sensing ion channels
- AP:
Acute pancreatitis
- ATP:
Adenosine-5′-triphosphate
- UTP:
Alpha-d-glucose-1-phosphate uridylyltransferase
- CLCs:
Ca2+-activated Cl− channels
- CaM:
Calmodulin
- PRSS1:
Cationic trypsinogen
- CCK:
Cholecystokinin
- CTRC:
Chymotrypsin C
- cAMP:
Cyclic adenosine monophosphate
- cGMP:
Cyclic guanosine monophosphate
- CF:
Cystic fibrosis
- DIDS:
Diisothiocyanostilbene disulfonate
- FAEEs:
Fatty acid ethyl esters
- FAs:
Fatty acids
- IP3 :
Inositol triphosphate
- [Ca2+]i :
Intracellular Ca2+ level
- IRK-8:
Inwardly rectifying K+ -8
- P2X:
Ionotropic purinoceptor
- NHE:
Na+/H+ exchangers
- PSTI:
Pancreatic secretory trypsin inhibitor
- PMCA:
Plasma membrane Ca2+ ATPase pump
- KCNQ1:
Potassium voltage-gated channel subfamily Q, member 1
- PAR2:
Protease-activated receptor 2
- ROS:
Reactive oxygen species
- SERCA:
Sarco/endoplasmic reticulum Ca2+-ATPase
- TLC:
Taurolithocholic acid
- TRPVs:
Transient receptor potential ion channels of the vanilloid subtype
- KCNKs:
Two-pore domain potassium channels
- TWIK-2:
Two-pore domain weakly inward rectifying
- ZGs:
Zymogen granules
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Acknowledgment
The research on pancreatic ducts was mostly supported by Hungarian National Development Agency grants (TÁMOP-4.2.2.A-11/1/KONV-2012-0035, TÁMOP-4.2.2-A-11/1/KONV-2012-0052 TÁMOP-4.2.2.A-11/1/KONV-2012-0073), the Hungarian Scientific Research Fund (OTKA NF105758, NF100677), and the Hungarian Academy of Sciences (BO 00174/10/5). Whereas, the experimental work on acinar cells was supported by Medical Research Council Programme Grants G0700167 and MR/J002771/1 as well as a Medical Research Council Professorship for OHP (G19/22/2). The authors declare that the experiments performed by them using the above-mentioned sources comply with the current laws of the country in which they were performed.
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First Department of Medicine, University of Szeged, Koranyi fsr. 8, SZEGED, H6720, Hungary
Peter Hegyi
MRC Group, School of Biosciences, Cardiff University, Sir Martin Evans Building, Wales, CF10 3AX, UK
Ole H. Petersen
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Dept. of Cell. and Molecular Medicine Lab. of Ion Channel Research, KU Leuven, Leuven, Belgium
Bernd Nilius
Deptartment of Neurobiology Biomedical Science Tower 3, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Susan G. Amara
Walther-Straub-Institut für Pharmakologi, Ludwig-Maximilians-Universität München Medizinische Fakultät, München, Germany
Thomas Gudermann
MPI für Biophysikalische Chemie Abt. Neurobiologie, Göttingen, Germany
Reinhard Jahn
Zytopathologie, Universität Marburg Inst. Zytobiologie und, Marburg, Germany
Roland Lill
Abteilung II, Max-Planck-Institut für Herz- und Lungen, Bad Nauheim, Germany
Stefan Offermanns
Cardiff University School of Biosciences, Cardiff, United Kingdom
Ole H. Petersen
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Hegyi, P., Petersen, O.H. (2013). The Exocrine Pancreas: The Acinar-Ductal Tango in Physiology and Pathophysiology. In: Nilius, B.,et al. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 165. Reviews of Physiology, Biochemistry and Pharmacology, vol 165. Springer, Cham. https://doi.org/10.1007/112_2013_14
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