TIMP1
Strwythurau PDB Human UniProt search:PDBeRCSB Rhestr o ddynodwyr PDB 1D2B,1OO9,1UEA,2J0T,3MA2,3V96
Dynodwyr
Cyfenwau	TIMP1, CLGI, EPA, EPO, HCI, TIMP, TIMP-1, TIMP metallopeptidase inhibitor 1
Dynodwyr allanol	OMIM:305370HomoloGene:36321GeneCards:TIMP1
PatrwmRNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd •peptidase inhibitor activity •GO:0048551 enzyme inhibitor activity •cytokine activity •metal ion binding •protease binding •GO:0001948, GO:0016582 protein binding •metalloendopeptidase inhibitor activity •growth factor activity •zinc ion binding Cydrannau o'r gell •GO:0005578 extracellular matrix •extracellular region •basement membrane •extracellular exosome •platelet alpha granule lumen •extracellular space •endoplasmic reticulum lumen •collagen Prosesau biolegol •response to cytokine •negative regulation of peptidase activity •GO:0010260 heneiddio •response to peptide hormone •platelet degranulation •wound healing •negative regulation of apoptotic process •extracellular matrix disassembly •negative regulation of trophoblast cell migration •response to organic substance •cell activation •cartilage development •regulation of integrin-mediated signaling pathway •positive regulation of cell population proliferation •response to hormone •negative regulation of membrane protein ectodomain proteolysis •negative regulation of endopeptidase activity •GO:0048553 negative regulation of catalytic activity •negative regulation of metallopeptidase activity •post-translational protein modification •regulation of signaling receptor activity •connective tissue replacement involved in inflammatory response wound healing •cytokine-mediated signaling pathway Sources:Amigo /QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7076	n/a
Ensembl	ENSG00000102265	n/a
UniProt	P01033 Q6FGX5	n/a
RefSeq (mRNA)	NM_003254	n/a
RefSeq (protein)	NP_003245 NP_003245.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn ycorff dynol gan y genynTIMP1 ywTIMP1 a elwir hefyd ynTIMP metallopeptidase inhibitor 1, isoform CRA_a a TIMP metallopeptidase inhibitor 1 (Saesneg). Segment oDNA yw'rgenyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp11.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TIMP1.

• "Higher levels of TIMP-1 expression are associated with a poor prognosis in triple-negative breast cancer.". Mol Cancer. 2016. PMID 27130446.
• "Aldosterone Induces Tissue Inhibitor of Metalloproteinases-1 Expression and Further Contributes to Collagen Accumulation: From Clinical to Bench Studies.". Hypertension. 2016. PMID 27113051.
• "Tissue inhibitor of metalloproteinases 1, a novel biomarker of tuberculosis.". Mol Med Rep. 2017. PMID 27959391.
• "TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway.". J Exp Clin Cancer Res. 2016. PMID 27644693.
• "Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients.". J Neurooncol. 2016. PMID 27619981.

• Genes on human chromosome
• Genynnau

• Erthyglau Bot Wici-Iechyd