SMAD3
Strwythurau PDB Human UniProt search:PDBeRCSB Rhestr o ddynodwyr PDB 2LB2,1MHD,1MJS,1MK2,1OZJ,1U7F,2LAJ,5OD6,5ODG
Dynodwyr
Cyfenwau	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3, SMAD family member 3
Dynodwyr allanol	OMIM:603109HomoloGene:55937GeneCards:SMAD3
PatrwmRNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd •phosphatase binding •GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity •R-SMAD binding •co-SMAD binding •RNA polymerase II transcription regulatory region sequence-specific DNA binding •transcription factor binding •metal ion binding •GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding •enzyme binding •transforming growth factor beta receptor binding •protein homodimerization activity •collagen binding •zinc ion binding •chromatin binding •GO:0001158 cis-regulatory region sequence-specific DNA binding •GO:0001948, GO:0016582 protein binding •double-stranded DNA binding •protein kinase binding •sequence-specific DNA binding •DNA binding •bHLH transcription factor binding •ubiquitin binding •identical protein binding •protein heterodimerization activity •chromatin DNA binding •ubiquitin protein ligase binding •beta-catenin binding •GO:0000983 RNA polymerase II general transcription initiation factor activity •DEAD/H-box RNA helicase binding •mineralocorticoid receptor binding •glucocorticoid receptor binding •primary miRNA binding •GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific •SMAD binding •GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific •GO:0001104 transcription coregulator activity Cydrannau o'r gell •cytoplasm •cnewyllyn cell •heteromeric SMAD protein complex •SMAD protein complex •transcription regulator complex •receptor complex •cellbilen •intracellular anatomical structure •nucleoplasm •nuclear inner membrane •cytosol •GO:0009327 protein-containing complex Prosesau biolegol •somitogenesis •skeletal system development •ureteric bud development •endoderm development •regulation of transforming growth factor beta2 production •embryonic pattern specification •GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II •negative regulation of osteoblast differentiation •heart looping •positive regulation of chondrocyte differentiation •positive regulation of alkaline phosphatase activity •positive regulation of interleukin-1 beta production •pericardium development •regulation of binding •negative regulation of wound healing •activation of cysteine-type endopeptidase activity involved in apoptotic process •transforming growth factor beta receptor signaling pathway •negative regulation of inflammatory response •positive regulation of positive chemotaxis •negative regulation of cell population proliferation •negative regulation of fat cell differentiation •cell-cell junction organization •GO:0009373 regulation of transcription, DNA-templated •extrinsic apoptotic signaling pathway •activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway •signal transduction involved in regulation of gene expression •in utero embryonic development •negative regulation of transforming growth factor beta receptor signaling pathway •nodal signaling pathway •GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated •negative regulation of cell growth •regulation of immune response •positive regulation of transforming growth factor beta3 production •T cell activation •activin receptor signaling pathway •regulation of striated muscle tissue development •embryonic foregut morphogenesis •positive regulation of bone mineralization •wound healing •negative regulation of apoptotic process •positive regulation of extracellular matrix assembly •GO:1901227 negative regulation of transcription by RNA polymerase II •positive regulation of epithelial to mesenchymal transition •GO:0019049, GO:0030683 mitigation of host defenses by virus •thyroid gland development •developmental growth •lens fiber cell differentiation •gastrulation •GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response •osteoblast differentiation •GO:1990744, GO:1990729 primary miRNA processing •negative regulation of osteoblast proliferation •osteoblast development •embryonic cranial skeleton morphogenesis •transdifferentiation •paraxial mesoderm morphogenesis •response to hypoxia •positive regulation of cell migration •mesoderm formation •regulation of transforming growth factor beta receptor signaling pathway •GO:1901313 positive regulation of gene expression •immune system development •positive regulation of focal adhesion assembly •liver development •regulation of epithelial cell proliferation •positive regulation of stress fiber assembly •GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II •negative regulation of mitotic cell cycle •negative regulation of cytosolic calcium ion concentration •canonical Wnt signaling pathway •protein stabilization •transcription, DNA-templated •GO:1903363 negative regulation of protein catabolic process •protein deubiquitination •positive regulation of nitric oxide biosynthetic process •negative regulation of lung blood pressure •positive regulation of pri-miRNA transcription by RNA polymerase II •negative regulation of cardiac muscle hypertrophy in response to stress •cellular response to transforming growth factor beta stimulus •cellular response to cytokine stimulus •positive regulation of protein import into nucleus •positive regulation of DNA-binding transcription factor activity •SMAD protein signal transduction •positive regulation of canonical Wnt signaling pathway •SMAD protein complex assembly •adrenal gland development Sources:Amigo /QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4088	n/a
Ensembl	ENSG00000166949	n/a
UniProt	P84022	n/a
RefSeq (mRNA)	NM_001145102 NM_001145103 NM_001145104 NM_005902	n/a
RefSeq (protein)	NP_001138574 NP_001138575 NP_001138576 NP_005893	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn ycorff dynol gan y genynSMAD3 ywSMAD3 a elwir hefyd ynSMAD family member 3 (Saesneg). Segment oDNA yw'rgenyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q22.33.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMAD3.

• "The SMAD3 transcription factor binds complex RNA structures with high affinity.". Nucleic Acids Res. 2017. PMID 29036649.
• "Autophagy regulates Endothelial-Mesenchymal transition by decreasing the phosphorylation level of Smad3.". Biochem Biophys Res Commun. 2017. PMID 28450107.
• "Endovascular Repair of Internal Mammary Artery Aneurysms in 2 Sisters with SMAD3 Mutation.". Ann Vasc Surg. 2017. PMID 28286188.
• "Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers.". J Allergy Clin Immunol. 2017. PMID 28011059.
• "SMAD3 Activation: A Converging Point of Dysregulated TGF-Beta Superfamily Signaling and Genetic Aberrations in Granulosa Cell Tumor Development?". Biol Reprod. 2016. PMID 27683263.

• Genes on human chromosome
• Genynnau

• Erthyglau Bot Wici-Iechyd