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Wicipedia
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RAD51

Oddi ar Wicipedia
RAD51
Strwythurau
PDBHuman UniProt search:PDBeRCSB
Rhestr o ddynodwyr PDB

1N0W,1B22

Dynodwyr
CyfenwauRAD51, BRCC5, FANCR, HHsRad51, HsT16930, MRMV2, RAD51A, RECA, RAD51 recombinase
Dynodwyr allanolOMIM:179617HomoloGene:2155GeneCards:RAD51
PatrwmRNA pattern


Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaiddnucleotide binding
DNA binding
ATP-dependent activity, acting on DNA
DNA strand exchange activity
DNA polymerase binding
protein C-terminus binding
GO:0001948, GO:0016582 protein binding
four-way junction DNA binding
identical protein binding
endodeoxyribonuclease activity
ATP binding
single-stranded DNA binding
double-stranded DNA binding
GO:0043142 single-stranded DNA helicase activity
chromatin binding
enzyme binding
Cydrannau o'r gellcytoplasm
site of double-strand break
PML body
Cytosgerbwd
nucleoplasm
microtubule organizing center
nuclear chromosome
mitochondrial matrix
nucleolus
mitocondria
perinuclear region of cytoplasm
chromatin
cnewyllyn cell
cytosol
GO:0009327 protein-containing complex
condensed chromosome
condensed nuclear chromosome
lateral element
Cromosom
Prosesau biolegolstrand invasion
GO:1903211 mitotic recombination-dependent replication fork processing
reciprocal meiotic recombination
DNA recombination
regulation of double-strand break repair via homologous recombination
DNA metabolic process
positive regulation of DNA ligation
cellular response to camptothecin
double-strand break repair via homologous recombination
cellular response to ionizing radiation
mitotic recombination
protein homooligomerization
GO:0100026 DNA repair
DNA unwinding involved in DNA replication
cellular response to DNA damage stimulus
interstrand cross-link repair
DNA recombinase assembly
negative regulation of G0 to G1 transition
telomere maintenance via recombination
telomere maintenance via telomere lengthening
replication fork processing
GO:0007126 Meiosis
GO:0051178 chromosome organization involved in meiotic cell cycle
Sources:Amigo /QuickGO
Orthologau
SpeciesBod dynolLlygoden
Entrez

5888

n/a

Ensembl

ENSG00000051180

n/a

UniProt

Q06609

n/a

RefSeq (mRNA)

NM_001164269
NM_001164270
NM_002875
NM_133487

n/a

RefSeq (protein)

NP_001157741
NP_001157742
NP_002866
NP_597994

n/a

Lleoliad (UCSC)n/an/a
PubMed search[1]n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn ycorff dynol gan y genynRAD51 ywRAD51 a elwir hefyd ynDNA repair protein RAD51 homolog 1 a RAD51 recombinase (Saesneg). Segment oDNA yw'rgenyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q15.1.[2]

Cyfystyron

[golygu |golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RAD51.

  • RECA
  • BRCC5
  • FANCR
  • MRMV2
  • HRAD51
  • RAD51A
  • HsRad51
  • HsT16930

Llyfryddiaeth

[golygu |golygu cod]
  • "Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein.". DNA Repair (Amst). 2017. PMID 29100040.
  • "A cell-penetrating antibody inhibits human RAD51 via direct binding.". Nucleic Acids Res. 2017. PMID 29036688.
  • "Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.". PLoS One. 2017. PMID 28099437.
  • "RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells.". Stem Cell Reports. 2017. PMID 28076755.
  • "Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange.". Nat Struct Mol Biol. 2017. PMID 27941862.

Cyfeiriadau

[golygu |golygu cod]
  1. "Human PubMed Reference:".
  2. RAD51 - Cronfa NCBI
Wedi dod o "https://cy.wikipedia.org/w/index.php?title=RAD51&oldid=4494229"
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