MXD1 |
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Dynodwyr |
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Cyfenwau | MXD1, BHLHC58, MAD, MAD1, MAX dimerization protein 1 |
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Dynodwyr allanol | OMIM:600021HomoloGene:1767GeneCards:MXD1 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | •GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity •GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding •DNA binding •GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific •GO:0001948, GO:0016582 protein binding •GO:0001104 transcription coregulator activity •protein dimerization activity •GO:0001106 transcription corepressor activity •GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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Cydrannau o'r gell | •cnewyllyn cell •nucleoplasm •mitocondria •cytosol
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Prosesau biolegol | •multicellular organism development •cell population proliferation •GO:0009373 regulation of transcription, DNA-templated •GO:1901227 negative regulation of transcription by RNA polymerase II •transcription, DNA-templated
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Sources:Amigo /QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn ycorff dynol gan y genynMXD1 ywMXD1 a elwir hefyd ynMAX dimerization protein 1 (Saesneg). Segment oDNA yw'rgenyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p13.3.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MXD1.
- "Effect of the transcriptional repressor Mad1 on proliferation of human melanoma cells.". Exp Dermatol. 2002. PMID 12366697.
- "Assignment of the human MAD and MXI1 genes to chromosomes 2p12-p13 and 10q24-q25.". Genomics. 1994. PMID 7829091.
- "miR-382-5p Controls Hematopoietic Stem Cell Differentiation Through the Downregulation of MXD1.". Stem Cells Dev. 2016. PMID 27520398.
- "TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction.". BMB Rep. 2016. PMID 26698869.
- "The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription.". Mol Carcinog. 2009. PMID 19526459.