MSH2
Strwythurau PDB Human UniProt search:PDBeRCSB Rhestr o ddynodwyr PDB 2O8B,2O8C,2O8D,2O8E,2O8F,3THW,3THX,3THY,3THZ
Dynodwyr
Cyfenwau	MSH2, mutS homolog 2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2, hMMRCS2, MSH-2
Dynodwyr allanol	OMIM:609309HomoloGene:210GeneCards:MSH2
PatrwmRNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd •DNA binding •nucleotide binding •protein homodimerization activity •mismatched DNA binding •dinucleotide insertion or deletion binding •ADP binding •centromeric DNA binding •oxidized purine DNA binding •single-stranded DNA binding •damaged DNA binding •ATPase activity •protein C-terminus binding •GO:0001948, GO:0016582 protein binding •single thymine insertion binding •four-way junction DNA binding •MutLalpha complex binding •enzyme binding •double-stranded DNA binding •dinucleotide repeat insertion binding •ATP binding •protein kinase binding •magnesium ion binding •single guanine insertion binding •guanine/thymine mispair binding •Y-form DNA binding •heteroduplex DNA loop binding •double-strand/single-strand DNA junction binding •ATP-dependent activity, acting on DNA •chromatin binding Cydrannau o'r gell •MutSbeta complex •bilen •MutSalpha complex •nucleoplasm •mismatch repair complex •cnewyllyn cell •Cromosom Prosesau biolegol •GO:1904089 negative regulation of neuron apoptotic process •germ cell development •male gonad development •postreplication repair •determination of adult lifespan •in utero embryonic development •cellular response to DNA damage stimulus •oxidative phosphorylation •maintenance of DNA repeat elements •positive regulation of helicase activity •somatic recombination of immunoglobulin gene segments •intrinsic apoptotic signaling pathway in response to DNA damage •negative regulation of DNA recombination •somatic recombination of immunoglobulin genes involved in immune response •DNA mismatch repair •B cell differentiation •B cell mediated immunity •GO:0100026 DNA repair •positive regulation of isotype switching to IgA isotypes •positive regulation of isotype switching to IgG isotypes •double-strand break repair •meiotic gene conversion •response to X-ray •response to UV-B •somatic hypermutation of immunoglobulin genes •mitotic intra-S DNA damage checkpoint signaling •intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator •negative regulation of reciprocal meiotic recombination •isotype switching •protein localization to chromatin •DNA recombination Sources:Amigo /QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4436	n/a
Ensembl	ENSG00000095002	n/a
UniProt	P43246	n/a
RefSeq (mRNA)	NM_000251 NM_001258281	n/a
RefSeq (protein)	NP_000242 NP_001245210	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn ycorff dynol gan y genynMSH2 ywMSH2 a elwir hefyd ynMutS homolog 2 (Saesneg). Segment oDNA yw'rgenyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2p21-p16.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MSH2.

• "Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations.". PLoS Genet. 2017. PMID 28422960.
• "Overexpression of MutSα Complex Proteins Predicts Poor Prognosis in Oral Squamous Cell Carcinoma.". Medicine (Baltimore). 2016. PMID 27258499.
• "Causes of Cancer Death Among First-Degree Relatives in Japanese Families with Lynch Syndrome.". Anticancer Res. 2016. PMID 27069191.
• "Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants.". Proc Natl Acad Sci U S A. 2016. PMID 26951660.
• "A cryptic paracentric inversion of MSH2 exons 2-6 causes Lynch syndrome.". Carcinogenesis. 2016. PMID 26498247.

• Genes on human chromosome
• Genynnau

• Erthyglau Bot Wici-Iechyd