ITGB2
Strwythurau PDB Human UniProt search:PDBeRCSB Rhestr o ddynodwyr PDB 1L3Y,1YUK,2JF1,2P26,2P28,3K6S,3K71,3K72,2V7D,4NEH,4NEN,5E6X,5E6V,5E6S,5E6R,5E6W,5ES4,5E6U
Dynodwyr
Cyfenwau	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin subunit beta 2
Dynodwyr allanol	OMIM:600065HomoloGene:20092GeneCards:ITGB2
PatrwmRNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd •GO:0032403 protein-containing complex binding •metal ion binding •GO:0001948, GO:0016582 protein binding •protein heterodimerization activity •ICAM-3 receptor activity •protein kinase binding •cell adhesion molecule binding •heat shock protein binding •amyloid-beta binding •complement component C3b binding •integrin binding •signaling receptor activity •cargo receptor activity Cydrannau o'r gell •integral component of membrane •extracellular vesicle •integrin alphaL-beta2 complex •bilen •Cellbilen •receptor complex •cell surface •integrin complex •extracellular exosome •specific granule membrane •tertiary granule membrane •ficolin-1-rich granule membrane •focal adhesion •external side of plasma membrane •integrin alphaM-beta2 complex •plasma membrane raft •membrane raft •cytoplasmic region •GO:0009327 protein-containing complex Prosesau biolegol •leukocyte cell-cell adhesion •endodermal cell differentiation •toll-like receptor 4 signaling pathway •positive regulation of nitric oxide biosynthetic process •heterotypic cell-cell adhesion •cell-cell signaling •GO:0010260 heneiddio •receptor internalization •leukocyte migration involved in inflammatory response •natural killer cell activation •cellular response to low-density lipoprotein particle stimulus •extracellular matrix organization •receptor clustering •positive regulation of angiogenesis •neutrophil chemotaxis •cell adhesion •positive regulation of NF-kappaB transcription factor activity •regulation of cell shape •regulation of immune response •cellular extravasation •integrin-mediated signaling pathway •cell-matrix adhesion •inflammatory response •endothelial cell migration •leukocyte migration •regulation of peptidyl-tyrosine phosphorylation •GO:0097285 apoptotic process •ffagocytosis •neutrophil degranulation •microglial cell activation •receptor-mediated endocytosis •phagocytosis, engulfment •cell migration •cytokine-mediated signaling pathway •positive regulation of superoxide anion generation •cell adhesion mediated by integrin •positive regulation of neutrophil degranulation •negative regulation of dopamine metabolic process •positive regulation of protein targeting to membrane •amyloid-beta clearance •cell-cell adhesion •cell-cell adhesion via plasma-membrane adhesion molecules •positive regulation of neuron death •positive regulation of microglial cell activation •neutrophil migration •positive regulation of prostaglandin-E synthase activity •positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo /QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3689	n/a
Ensembl	ENSG00000160255	n/a
UniProt	P05107	n/a
RefSeq (mRNA)	NM_000211 NM_001127491 NM_001303238	n/a
RefSeq (protein)	NP_000202 NP_001120963 NP_001290167	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn ycorff dynol gan y genynITGB2 ywITGB2 a elwir hefyd ynIntegrin beta ac Integrin subunit beta 2 (Saesneg). Segment oDNA yw'rgenyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 21, band 21q22.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITGB2.

• "Altered levels of soluble CD18 may associate immune mechanisms with outcome in sepsis.". Clin Exp Immunol. 2017. PMID 28714582.
• "LFA-1 Activation in NK Cells and Their Subsets: Influence of Receptors, Maturation, and Cytokine Stimulation.". J Immunol. 2017. PMID 28100681.
• "Quantitative Protein Sulfenic Acid Analysis Identifies Platelet Releasate-Induced Activation of Integrin β2 on Monocytes via NADPH Oxidase.". J Proteome Res. 2016. PMID 27690452.
• "CD18 promoter methylation is associated with a higher risk of thrombotic complications in primary myelofibrosis.". Ann Hematol. 2016. PMID 27595148.
• "LFA-1 integrin antibodies inhibit leukocyte α4β1-mediated adhesion by intracellular signaling.". Blood. 2016. PMID 27443292.

• Genes on human chromosome
• Genynnau

• Erthyglau Bot Wici-Iechyd