CD28
Strwythurau PDB Human UniProt search:PDBeRCSB Rhestr o ddynodwyr PDB 1YJD,3WA4,5AUL
Dynodwyr
Cyfenwau	CD28, Tp44, CD28 molecule
Dynodwyr allanol	OMIM:186760HomoloGene:4473GeneCards:CD28
PatrwmRNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd •coreceptor activity •protease binding •GO:0001948, GO:0016582 protein binding •identical protein binding •protein kinase binding •phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cydrannau o'r gell •integral component of membrane •cytosol •bilen •Cellbilen •integral component of plasma membrane •immunological synapse •external side of plasma membrane •cell surface •protein complex involved in cell adhesion Prosesau biolegol •regulatory T cell differentiation •regulation of regulatory T cell differentiation •T cell costimulation •GO:0019049, GO:0030683 mitigation of host defenses by virus •positive regulation of translation •negative regulation of gene expression •negative thymic T cell selection •cell surface receptor signaling pathway •GO:1901313 positive regulation of gene expression •humoral immune response •positive regulation of T cell proliferation •positive regulation of alpha-beta T cell proliferation •GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response •apoptotic signaling pathway •positive regulation of phosphatidylinositol 3-kinase signaling •positive regulation of isotype switching to IgG isotypes •positive regulation of viral genome replication •T cell receptor signaling pathway •positive regulation of mitotic nuclear division •positive regulation of inflammatory response to antigenic stimulus •GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II •positive regulation of interleukin-10 production •phosphatidylinositol phosphate biosynthetic process •positive regulation of interleukin-4 production •positive regulation of protein kinase B signaling •T cell activation •negative regulation of apoptotic process •regulation of T cell proliferation •immune system process Sources:Amigo /QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	940	n/a
Ensembl	ENSG00000178562	n/a
UniProt	P10747	n/a
RefSeq (mRNA)	NM_001243077 NM_001243078 NM_006139	n/a
RefSeq (protein)	NP_001230006 NP_001230007 NP_006130	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn ycorff dynol gan y genynCD28 ywCD28 a elwir hefyd ynCD28 molecule (Saesneg). Segment oDNA yw'rgenyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q33.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD28.

• Tp44

• "Human mast cells costimulate T cells through a CD28-independent interaction.". Eur J Immunol. 2016. PMID 26860071.
• "Recurrent activating mutations of CD28 in peripheral T-cell lymphomas.". Leukemia. 2016. PMID 26719098.
• "Functional analysis of acquired CD28 mutations identified in cutaneous T cell lymphoma.". Cell Immunol. 2017. PMID 28711152.
• "CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade.". Mol Med Rep. 2016. PMID 27314219.
• "Loss of CD28 on Peripheral T Cells Decreases the Risk for Early Acute Rejection after Kidney Transplantation.". PLoS One. 2016. PMID 26950734.

• Genes on human chromosome
• Genynnau

• Erthyglau Bot Wici-Iechyd