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Most Innovative Startups in Pennsylvania - Disruptors to Watch

From workforce expansion to revenue spikes, these Pennsylvania state businesses led the charts in 2026. Recent data highlights standout performers likeHM Health Solutions,Brenntag North America andEurofins PSS Insourcing Solutions dominating the Pennsylvania state landscape. HM Health Solutions stands at the top Pennsylvania state, boasting an annual revenue of $89.8M and valuation, with a workforce of 500 employees. The list provided below to discover the latest information on funding, revenue, valuation, competitors, and net worth for the top companies in Pennsylvania state.

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Ranking Company Name Revenue Employees Website City State Country Industry
1company-faviconHM Health Solutions$89.8M500+hmhs.comPittsburghPennsylvaniaUnited StatesDigital Health
2company-faviconBrenntag North America$7.5M2500+brenntagnorthamerica.comReadingPennsylvaniaUnited StatesChemicals
3company-faviconEurofins PSS Insourcing Solutions$374.1M1800+eurofinsus.comLancasterPennsylvaniaUnited StatesPharmaceuticals
4company-faviconCardiacAssist$12M40+tandemlife.comPittsburghPennsylvaniaUnited StatesMedical Equip
5company-faviconDedicated Nursing Associates$99.6M600+dedicatednurses.comMurrysvillePennsylvaniaUnited StatesRecruiting
6company-faviconQualTek USA$620.2M1300+qualtekservices.comKing of PrussiaPennsylvaniaUnited StatesTelecom
7company-faviconSTV Group Incorporated$35M100+i95westriver.com DouglassvillePennsylvaniaUnited StatesServices
8company-faviconLANXESS Corporation$7.5M100+lanxess.usPittsburghPennsylvaniaUnited StatesServices
9company-faviconHarvest Table Culinary Group$69.6M200+harvesttableculinary.comPhiladelphiaPennsylvaniaUnited StatesHospitality
10company-faviconInperium Management Services$7.5M200+inperium.orgReadingPennsylvaniaUnited StatesNonProfit
11company-faviconManaged Labor Solutions$50.9M300+managedlabor.netAllentownPennsylvaniaUnited StatesRecruiting
12company-faviconDuolingo$226M2500+duolingo.comPittsburghPennsylvaniaUnited StatesEdTech
13company-faviconBeck Institute for Cognitive Behavior Therapy$46.9M100+beckinstitute.orgBala CynwydPennsylvaniaUnited StatesHealthcare
14company-faviconB Lab$97.4M200+bcorporation.netBerwynPennsylvaniaUnited StatesCivil
15company-faviconMissionStaff$13.5M90+missionstaff.comPhiladelphiaPennsylvaniaUnited StatesTech Services
16company-faviconNelson Frank$4M40+nelsonfrank.comPhiladelphiaPennsylvaniaUnited StatesRecruiting
17company-faviconSeer Interactive$41.5M200+seerinteractive.comPhiladelphiaPennsylvaniaUnited StatesAdtech
18company-faviconThe Jonus Group$50.6M200+jonusgroup.comWaynePennsylvaniaUnited StatesInsurance
19company-faviconPhenom People$351.6M1700+phenompeople.comAmblerPennsylvaniaUnited StatesAnalytics
20company-favicongoPuff$708.2M3500+gopuff.comPhiladelphiaPennsylvaniaUnited StatesRetail
21company-faviconLinode$11.2M70+linode.comPhiladelphiaPennsylvaniaUnited StatesTech Services
22company-faviconMedErgy HealthGroup$48.6M200+medergygroup.comYardleyPennsylvaniaUnited StatesPharmaceuticals
23company-faviconLLR Partners$35M100+llrpartners.comPhiladelphiaPennsylvaniaUnited StatesVC/PE
24company-faviconTerrain$126.8M400+shopterrain.comPhiladelphiaPennsylvaniaUnited StatesRetail
25company-faviconRegulatory and Quality Solutions$161.6M600+rqteam.comMonroevillePennsylvaniaUnited StatesMedical Equip
26company-faviconFidato Partners$1.8M10+fidatopartners.comPhiladelphiaPennsylvaniaUnited StatesConsulting
27company-faviconERIKS North America$75M500+eriksna.comCoraopolisPennsylvaniaUnited StatesWholesale
28company-faviconNiche.com$115.7M600+niche.comPittsburghPennsylvaniaUnited StatesAnalytics
29company-faviconKeller Williams Real Estate$270.1M1200+johnmcclintock.comNewtownPennsylvaniaUnited StatesReal Estate
30company-faviconNational Philanthropic Trust$35M200+nptrust.orgJenkintownPennsylvaniaUnited StatesPhilanthropy

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