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1. (n.) Hopelessness; despondency; discouragement\.

2. (v. t.) To give up as beyond hope or expectation; to despair of.

3. (v. t.) To cause to despair.

4. (n.) Loss of hope; utter hopelessness; complete despondency.

5. (n.) That which is despaired of.

SchmerzSlough of Despondabandonabandon hopeacediaaching heartagonyagony of mindanguishapathybalebecome suicidalbitternessblank despondencybleeding heartbroken heartcave of Trophoniuscave of despaircrushingdeath wishdejectednessdejectiondepressiondepth of miserydesolationdespair ofdesperatenessdesperationdesponddespondencydespondentnessdisconsolatenessdiscouragementdisheartenmentdispiritednessdistressdown tripdowncastnessdownerdownheartednessdroopdrooping spiritsdropextremityfalterforlornnessgive upgive up hopegive waygloomgloominessgriefheartacheheartlessnessheavy hearthit rock bottomhopelessnessinfelicitylanguishlose heartlose hopelow spiritslownesslowness of spiritmalaisemelancholiamelancholymiserablenessmiseryno exitno wayno way outoppressionpessimismplumb the depthsprostrationquitreach the depthsrelinquishrenounceresignresignationsadnessself-destructive urgesinksink into despairsinking heartslothspiritlessnesssuicidal despairsurrendertaedium vitaetouch bottomweariness of lifewoewretchednessyieldyield to despair