The Top 300 of 2023

Provided by the ClinCalc DrugStats Database

ClinCalc.com »Pharmacy »ClinCalc DrugStats » Top 300 Drugs

The Top 300 Drugs of 2023

Rank	Drug Name	Total Prescriptions (2023)	Total Patients (2023)	Annual Change
1	Atorvastatin	115,271,514	29,359,439	0
2	Metformin	85,685,925	20,439,610	0
3	Levothyroxine	80,930,390	18,222,687	1
4	Lisinopril	76,055,039	18,501,311	1
5	Amlodipine	68,743,650	17,890,210	0
6	Metoprolol	59,547,256	14,849,955	0
7	Albuterol	59,546,183	19,491,794	0
8	Losartan	56,174,734	14,084,276	0
9	Gabapentin	45,964,505	11,372,821	1
10	Omeprazole	45,290,895	12,767,473	1
11	Sertraline	42,578,018	9,388,487	0
12	Rosuvastatin	42,103,429	11,790,764	1
13	Pantoprazole	37,101,751	9,335,363	3
14	Escitalopram	37,088,584	8,758,483	1
15	Dextroamphetamine; Dextroamphetamine Saccharate; Amphetamine; Amphetamine Aspartate	32,566,892	4,718,419	1
16	Hydrochlorothiazide	31,775,977	8,891,444	4
17	Bupropion	30,349,390	6,316,963	4
18	Fluoxetine	27,518,944	5,723,737	4
19	Semaglutide	25,954,066	5,453,051	29
20	Montelukast	25,893,501	6,495,486	3
21	Trazodone	24,708,571	5,601,459	3
22	Simvastatin	24,585,762	6,448,427	3
23	Amoxicillin	23,510,711	18,545,966	3
24	Tamsulosin	22,898,080	6,660,839	4
25	Acetaminophen; Hydrocodone	21,506,768	7,545,384	2
26	Fluticasone	21,041,607	8,198,679	1
27	Meloxicam	20,703,689	6,804,169	2
28	Apixaban	19,829,711	4,903,848	1
29	Furosemide	19,138,347	5,488,921	5
30	Insulin Glargine	18,424,802	4,007,889	2
31	Duloxetine	18,067,156	4,261,516	0
32	Ibuprofen	17,525,800	9,910,191	1
33	Famotidine	16,883,437	5,210,639	16
34	Empagliflozin	16,744,581	3,796,361	22
35	Carvedilol	16,566,781	4,288,833	1
36	Tramadol	16,010,294	4,995,781	19
37	Alprazolam	15,881,366	3,296,320	4
38	Prednisone	15,794,243	9,128,022	8
39	Hydroxyzine	15,272,377	4,112,936	7
40	Buspirone	15,229,212	3,587,235	14
41	Clopidogrel	15,227,565	4,090,131	6
42	Glipizide	15,173,475	3,896,020	0
43	Citalopram	14,769,554	3,176,952	3
44	Potassium Chloride	14,514,606	4,177,294	9
45	Allopurinol	14,311,839	3,349,088	6
46	Aspirin	14,095,181	5,257,546	10
47	Cyclobenzaprine	13,973,843	5,283,574	2
48	Ergocalciferol	13,705,855	4,459,410	10
49	Oxycodone	13,502,066	5,654,494	11
50	Methylphenidate	13,248,734	2,350,510	18
51	Venlafaxine	13,234,839	2,973,726	7
52	Spironolactone	12,777,045	3,515,708	0
53	Ondansetron	12,503,157	6,097,220	8
54	Zolpidem	11,424,127	2,405,571	12
55	Cetirizine	11,399,497	3,931,282	12
56	Estradiol	11,289,112	3,347,560	6
57	Pravastatin	11,060,711	3,160,612	20
58	Hydrochlorothiazide; Lisinopril	10,986,814	2,395,399	5
59	Lamotrigine	10,895,178	2,048,990	1
60	Quetiapine	10,655,017	1,940,616	22
61	Fluticasone; Salmeterol	10,648,080	2,739,984	2
62	Clonazepam	10,614,830	2,195,742	5
63	Dulaglutide	10,358,270	2,228,365	11
64	Azithromycin	10,337,595	8,348,688	14
65	Hydrochlorothiazide; Losartan	9,882,017	2,369,334	10
66	Amoxicillin; Clavulanate	9,831,525	7,511,826	30
67	Latanoprost	9,792,338	2,715,551	0
68	Cholecalciferol	9,737,465	3,328,507	6
69	Propranolol	9,699,272	2,436,578	8
70	Ezetimibe	9,686,244	2,860,227	9
71	Topiramate	9,619,219	2,029,275	13
72	Paroxetine	9,577,610	1,753,057	20
73	Diclofenac	9,438,696	3,411,516	22
74	Budesonide; Formoterol	9,346,242	2,269,426	9
75	Atenolol	9,235,305	2,669,869	12
76	Lisdexamfetamine	9,134,058	1,477,908	7
77	Doxycycline	8,823,028	5,847,755	9
78	Pregabalin	8,644,140	1,726,535	13
79	Ethinyl Estradiol; Norethindrone	8,611,956	2,206,708	1
80	Glimepiride	8,459,350	2,078,077	16
81	Tizanidine	8,292,865	2,502,146	13
82	Clonidine	8,128,031	1,740,033	11
83	Fenofibrate	8,093,230	1,938,765	5
84	Insulin Lispro	8,053,451	1,834,930	14
85	Valsartan	7,983,441	2,158,502	32
86	Cephalexin	7,869,737	5,838,328	15
87	Baclofen	7,753,150	1,590,627	17
88	Rivaroxaban	7,743,941	1,936,505	2
89	Ferrous Sulfate	7,699,088	2,668,685	18
90	Amitriptyline	7,568,933	1,658,411	3
91	Finasteride	7,546,064	2,365,922	18
92	Dapagliflozin	7,444,831	1,793,760	23
93	Acetaminophen; Oxycodone	7,283,471	2,355,340	5
94	Folic Acid	7,276,938	2,168,940	29
95	Aripiprazole	7,197,548	1,608,575	11
96	Olmesartan	7,175,746	1,957,158	1
97	Ethinyl Estradiol; Norgestimate	7,175,433	1,866,523	2
98	Valacyclovir	7,121,821	2,794,911	15
99	Mirtazapine	6,977,141	1,616,829	6
100	Lorazepam	6,963,899	2,048,781	19
101	Levetiracetam	6,904,402	1,111,637	22
102	Insulin Aspart	6,835,070	1,683,030	26
103	Naproxen	6,808,486	3,219,878	14
104	Cyanocobalamin	6,727,915	2,081,388	27
105	Loratadine	6,699,690	2,271,288	33
106	Diltiazem	6,562,727	1,869,478	6
107	Sumatriptan	6,484,249	2,083,076	12
108	Triamcinolone	6,476,980	4,343,165	6
109	Hydralazine	6,327,003	1,863,936	12
110	Tirzepatide	6,310,173	1,324,240	0
111	Celecoxib	6,190,143	2,201,329	18
112	Acetaminophen	5,984,654	3,351,953	2
113	Alendronate	5,876,378	1,928,468	10
114	Oxybutynin	5,874,390	1,572,156	4
115	Hydrochlorothiazide; Triamterene	5,806,865	1,619,114	1
116	Warfarin	5,793,664	1,369,433	31
117	Progesterone	5,570,117	1,431,497	8
118	Fluticasone; Umeclidinium; Vilanterol	5,533,174	1,137,243	26
119	Testosterone	5,337,521	1,320,614	1
120	Nifedipine	5,318,746	1,327,349	31
121	Methocarbamol	5,288,774	2,566,436	5
122	Benzonatate	5,225,510	3,848,465	8
123	Sitagliptin	5,171,309	1,377,092	37
124	Chlorthalidone	5,041,667	1,459,485	16
125	Isosorbide	5,038,468	1,347,588	6
126	Donepezil	4,919,269	1,249,510	20
127	Dexmethylphenidate	4,826,840	944,279	18
128	Sulfamethoxazole; Trimethoprim	4,667,341	3,025,952	15
129	Clobetasol	4,643,351	2,351,795	27
130	Methotrexate	4,611,809	1,103,153	2
131	Hydroxychloroquine	4,438,796	1,199,079	19
132	Lovastatin	4,392,660	1,167,788	21
133	Pioglitazone	4,381,830	1,045,289	13
134	Irbesartan	4,225,718	1,003,836	66
135	Methylprednisolone	4,190,064	3,315,587	18
136	Norethindrone	4,162,876	1,470,696	1
137	Meclizine	4,086,408	1,598,165	8
138	Ethinyl Estradiol; Levonorgestrel	4,052,882	1,217,443	10
139	Fluticasone; Vilanterol	4,032,315	731,680	6
140	Ketoconazole	3,987,777	1,837,309	35
141	Thyroid	3,945,403	793,936	4
142	Azelastine	3,932,233	1,790,839	18
143	Nitrofurantoin	3,917,548	2,471,873	15
144	Adalimumab	3,900,241	591,018	97
145	Memantine	3,853,517	1,033,550	5
146	Prednisolone	3,839,256	2,456,200	10
147	Esomeprazole	3,828,168	1,097,633	25
148	Docusate	3,798,215	1,680,843	0
149	Clindamycin	3,775,741	2,471,485	2
150	Acyclovir	3,766,454	1,117,946	16
151	Sildenafil	3,760,682	1,215,572	6
152	Insulin Degludec	3,663,825	907,113	14
153	Insulin Detemir	3,584,061	817,923	26
154	Drospirenone; Ethinyl Estradiol	3,566,507	880,241	12
155	Ciprofloxacin	3,513,623	2,777,272	26
156	Morphine	3,500,073	647,436	16
157	Insulin Human; Insulin Isophane Human	3,487,065	540,782	35
158	Levocetirizine	3,461,897	982,120	6
159	Nirmatrelvir; Ritonavir	3,453,516	3,261,698	5
160	Valproate	3,442,917	625,116	14
161	Atomoxetine	3,431,315	755,464	52
162	Budesonide	3,366,337	890,477	15
163	Tiotropium	3,305,177	731,805	9
164	Melatonin	3,256,782	728,331	53
165	Cefdinir	3,168,051	2,519,650	3
166	Doxepin	3,122,267	604,157	52
167	Olanzapine	3,091,702	591,423	4
168	Phentermine	3,003,107	1,074,539	19
169	Ofloxacin	2,987,657	2,127,082	37
170	Ethinyl Estradiol; Etonogestrel	2,987,624	690,197	24
171	Mupirocin	2,982,603	2,180,313	9
172	Benazepril	2,965,135	712,858	13
173	Timolol	2,946,884	823,663	18
174	Magnesium Salts	2,903,672	821,090	33
175	Fluconazole	2,871,500	2,079,348	15
176	Risperidone	2,865,210	586,343	7
177	Verapamil	2,819,767	632,561	11
178	Linaclotide	2,817,174	720,731	11
179	Cyclosporine	2,796,137	1,250,521	6
180	Doxazosin	2,735,065	765,542	0
181	Albuterol; Ipratropium	2,727,765	788,302	3
182	Hydrocortisone	2,711,652	1,381,068	20
183	Diazepam	2,711,267	902,266	14
184	Telmisartan	2,693,425	661,282	44
185	Carbamazepine	2,687,079	512,106	0
186	Amlodipine; Benazepril	2,681,344	770,245	16
187	Lithium	2,680,151	464,216	25
188	Evolocumab	2,633,257	457,388	0
189	Desvenlafaxine	2,585,138	491,566	19
190	Dorzolamide	2,569,413	609,942	11
191	Nebivolol	2,568,389	844,304	18
192	Dicyclomine	2,561,309	1,016,843	16
193	Torsemide	2,545,175	700,275	9
194	Anastrozole	2,536,493	670,491	15
195	Enalapril	2,507,125	594,999	54
196	Polyethylene Glycol 3350	2,491,296	1,215,999	13
197	Tretinoin	2,454,022	1,349,696	41
198	Tadalafil	2,443,768	911,096	26
199	Sacubitril; Valsartan	2,442,361	657,646	34
200	Calcium	2,427,416	763,301	0
201	Pramipexole	2,398,374	551,096	8
202	Mesalamine	2,365,207	600,187	0
203	Metronidazole	2,318,178	1,737,004	70
204	Nortriptyline	2,314,282	574,267	13
205	Emtricitabine; Tenofovir	2,273,387	413,965	0
206	Rimegepant	2,263,880	455,115	0
207	Nitroglycerin	2,238,376	1,017,732	11
208	Rizatriptan	2,219,594	862,728	18
209	Liraglutide	2,191,691	671,031	70
210	Acetaminophen; Codeine	2,189,480	1,131,229	44
211	Ramipril	2,148,133	576,128	24
212	Ropinirole	2,086,907	707,906	49
213	Brimonidine	2,061,060	479,974	14
214	Mirabegron	2,045,781	660,130	8
215	Colchicine	2,010,102	798,172	18
216	Ticagrelor	2,006,287	541,032	13
217	Terazosin	1,989,756	573,398	0
218	Amiodarone	1,974,861	678,884	19
219	Fexofenadine	1,951,572	542,033	38
220	Liothyronine	1,884,613	568,396	16
221	Bisoprolol	1,816,701	562,441	28
222	Omega-3-acid Ethyl Esters	1,810,280	602,843	2
223	Flecainide	1,805,937	501,667	0
224	Oxcarbazepine	1,763,679	391,344	57
225	Desogestrel; Ethinyl Estradiol	1,722,386	581,721	64
226	Ascorbic Acid	1,705,386	623,102	0
227	Sodium Salts	1,698,017	591,392	11
228	Ketorolac	1,627,126	1,045,788	5
229	Dorzolamide; Timolol	1,620,620	460,097	4
230	Promethazine	1,611,034	805,538	32
231	Levofloxacin	1,583,754	1,094,753	20
232	Labetalol	1,555,592	539,610	17
233	Nystatin	1,528,640	856,580	3
234	Cyproheptadine	1,522,003	292,977	59
235	Erythromycin	1,513,465	1,086,795	36
236	Dutasteride	1,505,889	471,334	0
237	Moxifloxacin	1,504,242	1,012,790	36
238	Bimatoprost	1,491,206	433,473	43
239	Primidone	1,488,529	433,038	0
240	Sucralfate	1,487,376	527,574	26
241	Betamethasone; Clotrimazole	1,470,861	649,237	1
242	Senna; Docusate	1,440,174	571,667	19
243	Bumetanide	1,419,204	389,856	0
244	Icosapent Ethyl	1,378,688	399,887	15
245	Solifenacin	1,292,098	435,495	35
246	Dexamethasone	1,251,533	660,725	12
247	Epinephrine	1,248,425	722,247	7
248	Penicillin V	1,240,696	1,042,246	11
249	Calcitriol	1,217,012	320,997	5
250	Oseltamivir	1,207,283	1,018,277	45
251	Polymyxin B; Trimethoprim	1,200,830	1,105,738	1
252	Dextromethorphan; Promethazine	1,195,581	958,832	8
253	Terbinafine	1,181,009	722,494	2
254	Linagliptin	1,158,876	440,093	0
255	Methimazole	1,128,558	350,343	0
256	Metoclopramide	1,116,507	495,884	11
257	Medroxyprogesterone	1,095,997	417,258	19
258	Pancrelipase Amylase; Pancrelipase Lipase; Pancrelipase Protease	1,076,565	269,108	5
259	Clotrimazole	1,058,881	569,947	0
260	Dexamethasone; Neomycin; Polymyxin B	1,049,128	832,122	14
261	Calcium Phosphate; Cholecalciferol	1,043,667	418,270	15
262	Acetaminophen; Butalbital; Caffeine	1,039,901	655,619	14
263	Guanfacine	1,039,054	176,625	12
264	Sodium Fluoride	1,037,661	559,898	43
265	Codeine; Guaifenesin	972,224	834,325	7
266	Lactulose	966,210	388,255	1
267	Fluorouracil	964,215	793,472	3
268	Ipratropium	944,080	538,618	49
269	Olopatadine	930,171	377,675	19
270	Chlorhexidine	912,485	777,371	40
271	Nabumetone	869,463	270,062	32
272	Mometasone	865,193	545,150	39
273	Polyethylene Glycol 3350 With Electrolytes	842,997	785,849	9
274	Hydroquinone	835,288	449,868	6
275	Phenazopyridine	827,433	633,150	0
276	Loperamide	822,307	351,347	21
277	Lidocaine	810,186	482,428	15
278	Ciclopirox	787,556	502,983	31
279	Cefuroxime	783,926	626,445	4
280	Betamethasone	760,520	569,106	17
281	Brompheniramine; Dextromethorphan; Pseudoephedrine	748,649	578,476	16
282	Ethinyl Estradiol; Norgestrel	726,740	176,164	18
283	Ciprofloxacin; Dexamethasone	723,485	664,539	3
284	Diphenhydramine	707,624	278,928	26
285	Ethinyl Estradiol; Norelgestromin	658,000	219,111	18
286	Atropine; Diphenoxylate	614,352	222,391	2
287	Indomethacin	593,608	310,001	31
288	Niacin	534,979	138,204	29
289	Lactate	533,902	210,534	2
290	Vitamin E	519,661	265,241	46
291	Guaifenesin	511,688	252,124	4
292	Pseudoephedrine	497,307	260,899	14
293	Bisacodyl	481,188	210,150	22
294	Riboflavin	451,739	87,204	8
295	Ivermectin	450,417	117,070	19
296	Etodolac	450,221	232,690	17
297	Lactobacillus Acidophilus	445,216	193,744	77
298	Tobramycin	424,144	281,102	17
299	Ketotifen	409,520	185,557	56
300	Loratadine; Pseudoephedrine	408,298	118,353	11

Note: The data source (MEPS prescribed medicines file) is released annually by the U.S. Government. This data release represents survey data from two years prior. The ClinCalc DrugStats Database sanitizes and standardizes this data, and is typically released within a few months of the MEPS release. There is an inherent delay in collecting the survey data (eg, in the 2024 calendar year), MEPS releasing the data from patients (August 2026), and the ClinCalc DrugStats release (a few months later, classified as the 2024 drug list).Click here to read more about the process of creating the DrugStats database from the MEPS prescribed medicines file.

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2014-2023. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2025.08.Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed underCreative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Kane SP. The Top 300 of 2023, ClinCalc DrugStats Database, Version 2025.08. ClinCalc:https://clincalc.com/DrugStats/Top300Drugs.aspx. Updated August 10, 2025. Accessed February 16, 2026.

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