| Data | 23 de març de1991 |
|---|---|
| Distància | 294 km |
| Països |  Itàlia |
| Sortida | Milà |
| Arribada | Sanremo |
| Inscrits | 215 i 143 |
| Palmarès | |
| Vencedor | Claudio Chiappucci(ITA) |
| Temps del vencedor | 6h 56' 36" (42,342 km/h) |
| Segon |  Rolf Sørensen(DEN) |
| Tercer |  Eric Vanderaerden(BEL) |
LaMilà-Sanremo 1991 fou la 82a edició de laMilà-Sanremo. La cursa es disputà el23 de març de1991 i va ser guanyada per l'italiàClaudio Chiappucci, que s'imposà en solitari a la meta deSanremo.
215 ciclistes hi van prendre part, acabant la cursa 143 d'ells.
| Ciclista | Equip | Temps | |
|---|---|---|---|
| 1 | Claudio Chiappucci | Carrera Jeans | 6h 56' 36" |
| 2 | Rolf Sørensen | Ariostea | + 45" |
| 3 | Eric Vanderaerden | Buckler-Colnago-Decca | + 57" |
| 4 |  Djamolidine Abdoujaparov | Carrera Jeans | m. t. |
| 5 | Eddy Planckaert | Panasonic-Sportlife | m. t. |
| 6 |  Gérard Rué | Helvetia-Commodore | m. t. |
| 7 |  Phil Anderson | Motorola | m. t. |
| 8 |  Uwe Raab | Pdm-Ultima-Concorde | m. t. |
| 9 | Johnny Weltz | ONCE | m. t. |
| 10 | Andreas Kappes | Histor-Sigma | m. t. |
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