Movatterモバイル変換

[0]ホーム

Idi na sadržaj

Kaspaza-14

Uredi veze

S Wikipedije, slobodne enciklopedije

Kaspaza-14

Identifikatori

Aliasi

CASP14

Vanjski ID-jevi

OMIM:605848 MGI:1335092 HomoloGene:36304 GeneCards:CASP14

Lokacija gena (čovjek)

Hrom.	Hromosom 19 (čovjek)^[1]

Bend	19p13.12	Početak	15,049,480bp^[1]
Bend	19p13.12	Kraj	15,058,293bp^[1]

Lokacija gena (miš)

Hrom.	Hromosom 10 (miš)^[2]

Bend	10\|10 C1	Početak	78,547,825bp^[2]
Bend	10\|10 C1	Kraj	78,554,128bp^[2]

Ontologija gena
Molekularna funkcija	•GO:0070122 peptidase activity •cysteine-type endopeptidase activity •cysteine-type peptidase activity •GO:0001948, GO:0016582 vezivanje za proteine •hydrolase activity •endopeptidase activity •cysteine-type endopeptidase activity involved in execution phase of apoptosis •cysteine-type endopeptidase activity involved in apoptotic process
Ćelijska komponenta	•citoplazma •keratin filament •jedro •citosol •mitohondrija
Biološki proces	•cornification •Ćelijska diferencijacija •keratinization •Proteoliza •epidermis development •execution phase of apoptosis •GO:0097285 apoptoza •intrinsic apoptotic signaling pathway in response to DNA damage
Izvori:Amigo /QuickGO

Ortolozi

Vrste

Čovjek

Miš

Entrez


23581


12365

Ensembl


ENSG00000105141


ENSMUSG00000005355

UniProt


P31944


O89094

RefSeq (mRNK)


NM_012114


NM_009809

RefSeq (bjelančevina)


NP_036246


NP_033939

Lokacija (UCSC)

Chr 19: 15.05 – 15.06 Mb

Chr 10: 78.55 – 78.55 Mb

PubMed pretraga

^[3]

^[4]

Wikipodaci

Pogledaj/uredi – čovjek

Pogledaj/uredi – miš

Kaspaza-14 jestenzim koji je kodljudi kodiran genomCASP14 sahromosoma 19.^[5]^[6]^[7]

Funkcija

[uredi |uredi izvor]

Gen CASP14 kodira člana porodicecistein-aspartanih proteaza (kaspaza). Sekvencna aktivacija kaspaza ima centralnu ulogu u fazi izvršenjaćelijske apoptoze. Kaspaze postoje kao neaktivniproenzimi koji se podvrgavajuproteolitskoj obradi na konzerviranim asparaginskim ostacima kako bi se dobile dvije podjedinice, veliku i malu, koje se dimeriziraju i formiraju aktivni enzim. Pokazalo se da je ova kaspaza obrađena i aktivirana pomoćukaspaze-8 i10in vitro, i anti-Fas agonističkogantitijela ili TNF-ove apoptoze koja indukujeligandin vivo. Ekspresija i obrada ove kaspaze može biti uključena ukeratinocitnu terminalnu diferencijaciju, što je važno za formiranje kožne barijere.^[7]

PremaAtlasu ljudskih proteina,^[8] CASP14proteinom je obogaćena ljudskakoža i uglavnom je eksprimiran u gornjim slojevimaepiderme. Prema Atlasu ćelija, protein je uglavnom lokalizovan ucitosolu.^[9]

Također pogledajte

[uredi |uredi izvor]

Reference

[uredi |uredi izvor]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000105141 -Ensembl, maj 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000005355 -Ensembl, maj 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P (maj 1999)."Identification of a new caspase homologue: caspase-14".Cell Death Differ.5 (10): 838–46.doi:10.1038/sj.cdd.4400444.PMID 10203698.
^Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM (Dec 1998)."Caspase-14 is a novel developmentally regulated protease".J Biol Chem.273 (45): 29648–53.doi:10.1074/jbc.273.45.29648.PMID 9792675.
^^a ^b"Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase".
^Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Åsa; Kampf, Caroline; Sjöstedt, Evelina (23. 1. 2015). "Tissue-based map of the human proteome".Science (jezik: engleski).347 (6220): 1260419.doi:10.1126/science.1260419.ISSN 0036-8075.PMID 25613900.S2CID 802377.
^Thul, Peter J.; Åkesson, Lovisa; Wiking, Mikaela; Mahdessian, Diana; Geladaki, Aikaterini; Blal, Hammou Ait; Alm, Tove; Asplund, Anna; Björk, Lars (26. 5. 2017). "A subcellular map of the human proteome".Science (jezik: engleski).356 (6340): eaal3321.doi:10.1126/science.aal3321.ISSN 0036-8075.PMID 28495876.S2CID 10744558.

Dopunska literatura

[uredi |uredi izvor]

Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes".Electrophoresis.13 (12): 960–9.doi:10.1002/elps.11501301199.PMID 1286667.S2CID 41855774.
Ahmad M, Srinivasula SM, Hegde R, et al. (1998). "Identification and characterization of murine caspase-14, a new member of the caspase family".Cancer Res.58 (22): 5201–5.PMID 9823333.
Eckhart L, Ban J, Fischer H, Tschachler E (2000). "Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation".Biochem. Biophys. Res. Commun.277 (3): 655–9.doi:10.1006/bbrc.2000.3698.PMID 11062009.
Eckhart L, Declercq W, Ban J, et al. (2001)."Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation".J. Invest. Dermatol.115 (6): 1148–51.doi:10.1046/j.1523-1747.2000.00205.x.PMID 11121154.
Lippens S, Kockx M, Knaapen M, et al. (2001)."Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing".Cell Death Differ.7 (12): 1218–24.doi:10.1038/sj.cdd.4400785.PMID 11175259.
Pistritto G, Jost M, Srinivasula SM, et al. (2003). "Expression and transcriptional regulation of caspase-14 in simple and complex epithelia".Cell Death Differ.9 (9): 995–1006.doi:10.1038/sj.cdd.4401061.PMID 12181750.S2CID 23933663.
Chien AJ, Presland RB, Kuechle MK (2002). "Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation".Biochem. Biophys. Res. Commun.296 (4): 911–7.doi:10.1016/S0006-291X(02)02015-6.PMID 12200134.
Rendl M, Ban J, Mrass P, et al. (2003)."Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner".J. Invest. Dermatol.119 (5): 1150–5.doi:10.1046/j.1523-1747.2002.19532.x.PMID 12445205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Lippens S, Kockx M, Denecker G, et al. (2004)."Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures".Am. J. Pathol.165 (3): 833–41.doi:10.1016/s0002-9440(10)63346-9.PMC 1618612.PMID 15331408.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B): 2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Walsh DS, Borke JL, Singh BB, et al. (2005)."Psoriasis is characterized by altered epidermal expression of caspase 14, a novel regulator of keratinocyte terminal differentiation and barrier formation".J. Dermatol. Sci.37 (1): 61–3.doi:10.1016/j.jdermsci.2004.10.003.PMID 15619438.
Koenig U, Sommergruber W, Lippens S (2005). "Aberrant expression of caspase-14 in epithelial tumors".Biochem. Biophys. Res. Commun.335 (2): 309–13.doi:10.1016/j.bbrc.2005.07.072.PMID 16061209.
Krajewska M, Kim H, Shin E, et al. (2006)."Tumor-associated alterations in caspase-14 expression in epithelial malignancies".Clin. Cancer Res.11 (15): 5462–71.doi:10.1158/1078-0432.CCR-04-2527.PMID 16061862.
Kam DW, Charles AK, Dharmarajan AM (2005)."Caspase-14 expression in the human placenta".Reprod. Biomed. Online.11 (2): 236–43.doi:10.1016/S1472-6483(10)60964-9.PMID 16168224.
Park K, Kuechle MK, Choe Y, et al. (2006). "Expression and characterization of constitutively active human caspase-14".Biochem. Biophys. Res. Commun.347 (4): 941–8.doi:10.1016/j.bbrc.2006.06.156.PMID 16854378.
White L, Dharmarajan A, Charles A (2007)."Caspase-14: a new player in cytotrophoblast differentiation".Reprod. Biomed. Online.14 (3): 300–7.doi:10.1016/S1472-6483(10)60871-1.PMID 17359582.
Hsu S, Qin H, Dickinson D, et al. (2007). "Expression of caspase-14 reduces tumorigenicity of skin cancer cells".In Vivo.21 (2): 279–83.PMID 17436577.

Vanjski linkovi

[uredi |uredi izvor]

TheMEROPS online database for peptidases and their inhibitors:C14.018 Arhivirano 24. 10. 2007. naWayback Machine

p r u Proteaza:Cisteinska proteaza (EC 3.4.22)
Kaspaza	Kaspaza-1 Kaspaza-2 Kaspaza-3 Kaspaza-4 Kaspaza-5 Kaspaza-6 Kaspaza-7 Kaspaza-8 Kaspaza-9 Kaspaza-10 Kaspaza-12 Kaspaza-13 Kaspaza-14
Izvedene izplodova	Papain Fikain Bromelain Aktinidain
Kalpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
Katepsin	B C F H K L1/L2 O S W Z
Ostale	Klostripain Kancerski prokoagulant Separaza Autofagin Kruzipain 3C-lika proteaza

Preuzeto iz "https://bs.wikipedia.org/w/index.php?title=Kaspaza-14&oldid=3578950"

Kategorije:

Sakrivene kategorije:

[8]ページ先頭