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FOXB1

S Wikipedije, slobodne enciklopedije
FOXB1
Identifikatori
AliasiFOXB1
Vanjski ID-jeviMGI:1927549HomoloGene:8138GeneCards:FOXB1
Lokacija gena (čovjek)
Hromosom 15 (čovjek)
Hrom.Hromosom 15 (čovjek)[1]
Hromosom 15 (čovjek)
Genomska lokacija za FOXB1
Genomska lokacija za FOXB1
Bend15q22.2Početak60,004,234bp[1]
Kraj60,061,730bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za FOXB1
Genomska lokacija za FOXB1
Bend9 D|9 38.76 cMPočetak69,664,992bp[2]
Kraj69,668,222bp[2]
Ontologija gena
Molekularna funkcija•vezivanje sa DNK
•GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
•GO:0001948, GO:0016582 vezivanje za proteine
•sequence-specific DNA binding
•GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta•jedro
Biološki proces•visual learning
•somitogenesis
•GO:1904089 negative regulation of neuron apoptotic process
•mammillary body development
•mammillothalamic axonal tract development
•GO:0009373 regulation of transcription, DNA-templated
•axon target recognition
•mammary gland lobule development
•thalamus development
•transcription, DNA-templated
•floor plate development
•telencephalon cell migration
•cell migration in diencephalon
•inferior colliculus development
•spinal cord development
•urogenital system development
•lactation
•midbrain development
•epithelial cell differentiation involved in mammary gland alveolus development
•hypothalamus cell migration
•GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
•anatomical structure morphogenesis
•Ćelijska diferencijacija
Izvori:Amigo /QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

27023

64290

Ensembl

ENSG00000171956

ENSMUSG00000059246

UniProt

Q99853

Q64732

RefSeq (mRNK)

NM_012182

NM_022378

RefSeq (bjelančevina)

NP_036314

NP_071773

Lokacija (UCSC)Chr 15: 60 – 60.06 MbChr 9: 69.66 – 69.67 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Viljuškasta kutija B1 japrotein koji je kodljudikodirangenomFOXB1.[5]

Aminokiselinska sekvenca

[uredi |uredi izvor]

Dužinapolipeptidnog lanca je 325aminokiselina, amolekulska težina 34.978Da.[6].

1020304050
MPRPGRNTYSDQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIMDRFPYY
RENTQRWQNSLRHNLSFNDCFIKIPRRPDQPGKGSFWALHPSCGDMFENG
SFLRRRKRFKVLKSDHLAPSKPADAAQYLQQQAKLRLSALAASGTHLPQM
PAAAYNLGGVAQPSGFKHPFAIENIIAREYKMPGGLAFSAMQPVPAAYPL
PNQLTTMGSSLGTGWPHVYGSAGMIDSATPISMASGDYSAYGVPLKPLCH
AAGQTLPAIPVPIKPTPAAVPALPALPAPIPTLLSNSPPSLSPTSSQTAT
SQSSPATPSETLTSPASALHSVAVH
Simboli

C:Cistein
D:Asparaginska kiselina
E:Glutaminska kiselina
F:Fenilalanin
G:Glicin
H:Histidin
I:Izoleucin
K:Lizin
L:Leucin
M:Metionin
N:Asparagin
P:Prolin
Q:Glutamin
R:Arginin
S:Serin
T:Treonin
V:Valin
W:Triptofan
Y:Tirozin

Reference

[uredi |uredi izvor]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000171956 -Ensembl, maj 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000059246 -Ensembl, maj 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: Forkhead box B1". Pristupljeno 11. 9. 2014.
  6. ^"UniProt, Q99853". Pristupljeno 14. 7. 2021.

Vanjski linkovi

[uredi |uredi izvor]
(1) Basic domains
(1.1) Osnovnileucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Grupa C
bHLH-PAS
Grupa D
Grupa E
Grupa F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Cinkov prst DNA-binding domains
(2.1)Nuclear receptor(Cys4)
potporodica 1
potporodica 2
potporodica 3
potporodica 4
potporodica 5
potporodica 6
potporodica 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
ostali
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous
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