Protein 1 fumarilacetoacetat-hidrolaznog domena , znan i kao protein FLJ36880, jeenzim koji jr kodljudi kodiran genom FAHD1 sahromosoma 16 .[ 4]
Gen FAHD1 kodira protein od 24 kDa koji je lokaliziran umitohondrijama i pripada proteinskoj porodicifumarilacetoacetat-hidrolaza .[ 5] rendgenske kristalografije pri rezoluciji od 2,2 Å. Ukupna struktura slična jeC-terminalnom domenu bifunkcionalnog enzima HpcE izEscherichia coli Mus musculus E. coli 1262.[ 5] [ 6]
Aminokiselinska sekvenca
Dužinapolipeptidnog lanca je 224aminokiseline , amolekulska težina 24.843Da .[ 7]
10 20 30 40 50 MGIMAASRPL SRFWEWGKNI VCVGRNYADH VREMRSAVLS EPVLFLKPST AYAPEGSPIL MPAYTRNLHH ELELGVVMGK RCRAVPEAAA MDYVGGYALC LDMTARDVQD ECKKKGLPWT LAKSFTASCP VSAFVPKEKI PDPHKLKLWL KVNGELRQEG ETSSMIFSIP YIISYVSKII TLEEGDIILT GTPKGVGPVK ENDEIEAGIH GLVSMTFKVE KPEY
Simboli Pokazalo se da ueukariota protein FAHD1 funkcionira kaooksaloacetat -dekarboksilaza s.[ 8] acilpiruvaza , a pokazalo se da katalizirahidrolizu acetilpiruvata ifumarilpiruvata uin vitro [ 5] Mg (2+) .[ 6]
^a b c GRCm38: Ensembl release 89: ENSMUSG00000045316 -Ensembl , maj 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: FAHD1 fumarylacetoacetate hydrolase domain containing 1" .^a b c Manjasetty BA, Niesen FH, Delbrück H, Götz F, Sievert V, Büssow K, Behlke J, Heinemann U (2004)."X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880" .Biol. Chem .385 (10): 935–42.doi :10.1515/BC.2004.122 .PMID 15551868 .S2CID 16759973 . ^a b Pircher H, Straganz GD, Ehehalt D, Morrow G, Tanguay RM, Jansen-Dürr P (2011)."Identification of human fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) as a novel mitochondrial acylpyruvase" .J. Biol. Chem .286 (42): 36500–8.doi :10.1074/jbc.M111.264770 .PMC 3196145 PMID 21878618 . ^ "UniProt, Q6P587" . Pristupljeno 5. 7. 2021 .^ Pircher H, von Grafenstein S, Diener T, Metzger C, Albertini E, Taferner A, Unterluggauer H, Kramer C, Liedl KR, Jansen-Dürr P (2015)."Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase" .J. Biol. Chem .290 (11): 6755–62.doi :10.1074/jbc.M114.609305 .PMC 4358102 PMID 25575590 . Hartley JL, Temple GF, Brasch MA (2001)."DNA cloning using in vitro site-specific recombination" .Genome Res .10 (11): 1788–95.doi :10.1101/gr.143000 .PMC 310948 PMID 11076863 . Daniels RJ, Peden JF, Lloyd C, et al. (2001)."Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16" .Hum. Mol. Genet .10 (4): 339–52.doi :10.1093/hmg/10.4.339 PMID 11157797 . Wiemann S, Weil B, Wellenreuther R, et al. (2001)."Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" .Genome Res .11 (3): 422–35.doi :10.1101/gr.GR1547R .PMC 311072 PMID 11230166 . Simpson JC, Wellenreuther R, Poustka A, et al. (2001)."Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" .EMBO Rep .1 (3): 287–92.doi :10.1093/embo-reports/kvd058 .PMC 1083732 PMID 11256614 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" .Proc. Natl. Acad. Sci. U.S.A .99 (26): 16899–903.doi :10.1073/pnas.242603899 .PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs" .Nat. Genet .36 (1): 40–5.doi :10.1038/ng1285 PMID 14702039 . Lehner B, Sanderson CM (2004)."A protein interaction framework for human mRNA degradation" .Genome Res .14 (7): 1315–23.doi :10.1101/gr.2122004 .PMC 442147 PMID 15231747 . Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" .Genome Res .14 (10B): 2121–7.doi :10.1101/gr.2596504 .PMC 528928 PMID 15489334 . Wiemann S, Arlt D, Huber W, et al. (2004)."From ORFeome to biology: a functional genomics pipeline" .Genome Res .14 (10B): 2136–44.doi :10.1101/gr.2576704 .PMC 528930 PMID 15489336 . Manjasetty BA, Niesen FH, Delbrück H, et al. (2005). "X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880".Biol. Chem .385 (10): 935–42.doi :10.1515/BC.2004.122 .PMID 15551868 .S2CID 16759973 . Mehrle A, Rosenfelder H, Schupp I, et al. (2006)."The LIFEdb database in 2006" .Nucleic Acids Res .34 (Database issue): D415–8.doi :10.1093/nar/gkj139 .PMC 1347501 PMID 16381901 . 
