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DGAT2

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DGAT2

Identifikatori

Aliasi

DGAT2

Vanjski ID-jevi

OMIM:606983 MGI:1915050 HomoloGene:23580 GeneCards:DGAT2

EC broj

2.3.1.76

Lokacija gena (čovjek)

Hrom.	Hromosom 11 (čovjek)^[1]

Bend	11q13.5	Početak	75,759,512bp^[1]
Bend	11q13.5	Kraj	75,801,535bp^[1]

Lokacija gena (miš)

Hrom.	Hromosom 7 (miš)^[2]

Bend	7\|7 E1	Početak	98,802,865bp^[2]
Bend	7\|7 E1	Kraj	98,831,926bp^[2]

Ontologija gena
Molekularna funkcija	•protein homodimerization activity •acyltransferase activity, transferring groups other than amino-acyl groups •acyltransferase activity •2-acylglycerol O-acyltransferase activity •retinol O-fatty-acyltransferase activity •aktivnost sa transferazom •diacylglycerol O-acyltransferase activity
Ćelijska komponenta	•integral component of membrane •intracellular membrane-bounded organelle •Lipidna kapljica •perinuklearno područje citoplazme •integral component of endoplasmic reticulum membrane •membrana •Endoplazmatski retikulum •endoplasmic reticulum membrane •mitohondrija
Biološki proces	•regulation of cholesterol metabolic process •lipid storage •long-chain fatty-acyl-CoA metabolic process •positive regulation of gluconeogenesis •fat pad development •cellular response to oleic acid •fatty acid homeostasis •positive regulation of triglyceride biosynthetic process •lipid metabolism •regulation of plasma lipoprotein particle levels •negative regulation of fatty acid oxidation •acylglycerol acyl-chain remodeling •retinol metabolic process •low-density lipoprotein particle clearance •glycerol metabolic process •diacylglycerol metabolic process •cellular triglyceride homeostasis •cholesterol homeostasis •regulation of lipoprotein metabolic process •triglyceride biosynthetic process
Izvori:Amigo /QuickGO

Ortolozi

Vrste

Čovjek

Miš

Entrez


84649


67800

Ensembl


ENSG00000062282


ENSMUSG00000030747

UniProt


Q96PD7


Q9DCV3

RefSeq (mRNK)


NM_001253891 NM_032564


NM_026384

RefSeq (bjelančevina)


NP_001240820 NP_115953


NP_080660

Lokacija (UCSC)

Chr 11: 75.76 – 75.8 Mb

Chr 7: 98.8 – 98.83 Mb

PubMed pretraga

^[3]

^[4]

Wikipodaci

Pogledaj/uredi – čovjek

Pogledaj/uredi – miš

Diacilglicerol O-aciltransferaza 2 (DGAT2) jeprotein –enzim koji je kodljudi kodiran genomDGAT2.^[5]

Aminokiselinska sekvenca

[uredi |uredi izvor]

Dužinapolipeptidnog lanca je 388aminokiselina, amolekulska težina 43.831Da.^[6]

C:Cistein

D:Asparaginska kiselina

E:Glutaminska kiselina

F:Fenilalanin

G:Glicin

H:Histidin

I:Izoleucin

K:Lizin

L:Leucin

M:Metionin

N:Asparagin

P:Prolin

Q:Glutamin

R:Arginin

S:Serin

T:Treonin

V:Valin

W:Triptofan

Y:Tirozin

10	20	30	40	50
MKTLIAAYSG	VLRGERQAEA	DRSQRSHGGP	ALSREGSGRW	GTGSSILSAL
QDLFSVTWLN	RSKVEKQLQV	ISVLQWVLSF	LVLGVACSAI	LMYIFCTDCW
LIAVLYFTWL	VFDWNTPKKG	GRRSQWVRNW	AVWRYFRDYF	PIQLVKTHNL
LTTRNYIFGY	HPHGIMGLGA	FCNFSTEATE	VSKKFPGIRP	YLATLAGNFR
MPVLREYLMS	GGICPVSRDT	IDYLLSKNGS	GNAIIIVVGG	AAESLSSMPG
KNAVTLRNRK	GFVKLALRHG	ADLVPIYSFG	ENEVYKQVIF	EEGSWGRWVQ
KKFQKYIGFA	PCIFHGRGLF	SSDTWGLVPY	SKPITTVVGE	PITIPKLEHP
TQQDIDLYHT	MYMEALVKLF	DKHKTKFGLP	ETEVLEVN

Funkcija

[uredi |uredi izvor]

Ovaj gen kodira jedan od dvaenzima koji kataliziraju konačnu reakciju u sintezitriglicerida, u kojoj jediacilglicerol kovalentno vezan za masu dugog lancaacil-CoAs.

Kodirani protein katalizira ovu reakciju pri niskim koncentracijamamagnezij-hlorida, dok drugi enzim ima visoku aktivnost pri visokim koncentracijama magnezij-hlorida. Za ovaj gen je pronađeno više varijanti transkripta koje kodiraju različiteizoforme.

Reference

[uredi |uredi izvor]

1 2 3GRCh38: Ensembl release 89: ENSG00000062282 -Ensembl, maj 2017
1 2 3GRCm38: Ensembl release 89: ENSMUSG00000030747 -Ensembl, maj 2017
↑"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
↑"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
↑"Entrez Gene: Diacylglycerol O-acyltransferase 2". Pristupljeno 18. 7. 2017.
↑"UniProt, Q96PD7". Pristupljeno 20. 8. 2021.

Dopunska literatura

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Wakimoto K, Chiba H, Michibata H, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y (2003). "A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice".Biochem. Biophys. Res. Commun.310 (2): 296–302.doi:10.1016/j.bbrc.2003.09.015.PMID 14521909.
Ganji SH, Tavintharan S, Zhu D, Xing Y, Kamanna VS, Kashyap ML (2004)."Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells".J. Lipid Res.45 (10): 1835–45.doi:10.1194/jlr.M300403-JLR200.PMID 15258194.
Friedel S, Reichwald K, Scherag A, Brumm H, Wermter AK, Fries HR, Koberwitz K, Wabitsch M, Meitinger T, Platzer M, Biebermann H, Hinney A, Hebebrand J (2007)."Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13".BMC Genet.8: 17.doi:10.1186/1471-2156-8-17.PMC 1871603.PMID 17477860.
Friedel S, Reichwald K, Scherag A, Brumm H, Wermter AK, Fries HR, Koberwitz K, Wabitsch M, Meitinger T, Platzer M, Biebermann H, Hinney A, Hebebrand J (2007)."Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13".BMC Genet.8: 17.doi:10.1186/1471-2156-8-17.PMC 1871603.PMID 17477860.
Payne VA, Au WS, Gray SL, Nora ED, Rahman SM, Sanders R, Hadaschik D, Friedman JE, O'rahilly S, Rochford JJ (2007)."Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis".J. Biol. Chem.282 (29): 21005–14.doi:10.1074/jbc.M702871200.PMC 2254492.PMID 17504763.
Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV, Farese RV (2007). "Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle".Am. J. Physiol. Endocrinol. Metab.293 (6): E1772–81.doi:10.1152/ajpendo.00158.2007.PMID 17940217.
Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV (2008)."Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis".J. Lipid Res.49 (11): 2283–301.doi:10.1194/jlr.R800018-JLR200.PMC 3837458.PMID 18757836.
Kantartzis K, Machicao F, Machann J, Schick F, Fritsche A, Häring HU, Stefan N (2009). "The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans".Clin. Sci.116 (6): 531–7.doi:10.1042/CS20080306.PMID 18980578.
Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV (2009)."The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria".J. Biol. Chem.284 (8): 5352–61.doi:10.1074/jbc.M805768200.PMC 2643492.PMID 19049983.

Vanjski linkovi

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1Oksidoreduktaze/spisak EC2Transferaze/spisak EC3Hidrolaze/spisak EC4Lijaze/spisak EC5Izomeraze/spisak EC6Ligaze/spisak

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