Liam O'Brien is also known for his roles in many other anime and video games such as Caius Ballad in Final Fantasy XIII-2, Kain Highwind in Final Fantasy IV, Final Fantasy Dissidia 012, Gaara in Naruto, Captain Jushiro Ukitake in Bleach, Orlando Haddick in Catherine, Lloyd Asplund in Code Geass, Miguel Caballero Rojo in Tekken 6, and Vincent Law in Ergo Proxy.

Liam Christopher O'Brien is the voice actor who voiced Eddie Dombrowski in the Silent Hill HD Collection.