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Clinical and epidemiological research
TheTRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis
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  1. H M Albers1,
  2. F A S Kurreeman2,
  3. J J Houwing-Duistermaat3,
  4. D M C Brinkman1,
  5. S S M Kamphuis4,
  6. H J Girschick5,
  7. C Wouters6,
  8. M A J Van Rossum7,
  9. W Verduijn8,
  10. R E M Toes2,
  11. T W J Huizinga2,
  12. M W Schilham1,
  13. R ten Cate1
  1. 1Leiden University Medical Center, Department of Paediatrics, Leiden, The Netherlands
  2. 2Leiden University Medical Center, Department of Rheumatology, Leiden, The Netherlands
  3. 3Leiden University Medical Center, Department of Medical Statistics, Leiden, The Netherlands
  4. 4Erasmus Medical Center- Sophia Children’s Hospital, Department of Paediatric Immunology/Rheumatology, Rotterdam, The Netherlands
  5. 5University of Wuerzburg, Section of Paediatric Rheumatology, Wuerzburg, Germany
  6. 6University Hospital Gasthuisberg, Department of Paediatric Rheumatology, Leuven, Belgium
  7. 7Emma Children’s Hospital AMC, Department of Paediatrics, Amsterdam, The Netherlands
  8. 8Leiden University Medical Center, Department of Immunohaematology and Bloodbank, Leiden, The Netherlands
  1. R ten Cate, Department of Paediatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, the Netherlands;r.ten_cate{at}lumc.nl

Abstract

Objective: Juvenile idiopathic arthritis (JIA) is a chronic disorder in which both genetic and environmental factors are involved. Recently, we identified theTRAF1/C5 region (located on chromosome 9q33–34) as a risk factor for rheumatoid arthritis (RA) (pcombined = 1.4×10−8). In the present study the association of theTRAF1/C5 region with the susceptibility to JIA was investigated.

Methods: A case–control association study was performed in 338 Caucasian patients with JIA and 511 healthy individuals. We genotyped the single nucleotide polymorphism rs10818488 as a marker for theTRAF1/C5 region.

Results: The A allele was associated with the susceptibility to rheumatoid factor-negative polyarthritis with an 11% increase in allele frequency (OR 1.54, 95% CI 1.09 to 2.18; p = 0.012). This association was stronger when combining subtypes with a polyarticular phenotype (OR 1.46, 95% CI 1.12 to 1.90; p = 0.004). In addition, we observed a trend towards an increase in A allele frequency in patients with extended oligoarthritis versus persistent oligoarthritis (49%, 38% respectively); p = 0.055.

Conclusions: Apart from being a well replicated risk factor for RA,TRAF1/C5 also appears to be a risk factor for the rheumatoid factor-negative polyarthritis subtype of JIA and, more generally, seems to be associated with subtypes of JIA characterised by a polyarticular course.

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    Footnotes

    • Funding: This study is supported by research grants of the Dutch Arthritis Association (grant number NR-05-1-403 and KFS-04-2-202).

    • Competing interests: None.

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