Depression as a side effect of the contraceptive pill

@article{Kulkarni2007DepressionAA,  title={Depression as a side effect of the contraceptive pill},  author={Jayashri Kulkarni},  journal={Expert Opinion on Drug Safety},  year={2007},  volume={6},  pages={371 - 374},  url={https://api.semanticscholar.org/CorpusID:8836005}}
More research is needed to better inform women and doctors about depression related to oral contraceptive use, and clinical guidelines are needed regarding the different types of oral contraceptives and their potential depressogenic properties.

66 Citations

Combined Oral Contraceptives: Side Effects Review

For most women, oral contraception is safe, convenient and effective, but you should consult about the possible side effects and the importance of strict adherence to the regimen of oral contraceptives.

Effects of the Oral Contraceptive Pill: Psychological and Physiological Variables

An effect was observed in physiological variables; an increase in systolic blood pressure on the fourth week of pill cycle in those using Dianette and Ovranette and the purpose for which participants were using the OCP had an effect on SBP.

Hormonal contraception not a cause of depression?

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Hormonal contraception and mood disorders

Clinicians should consider the temporal relationship between the use of hormonal contraception and development of new or worsened depression or mood changes.

[Health risks of oral contraceptives].

It is important that doctors and pharmacists inform new users of OC about potential health risks of OC use, and that the personal and family history of previous health risks is assessed thoroughly in order to rule out that important and relevant contraindications are present when a women starts taking OC.

Oral hormonal contraception in special circumstances.

By using case histories, this work seeks to demonstrate the medical and practical complexities in managing contraceptive needs that may result in oral contraception being the most appropriate choice.

Use of hormonal contraceptives in relation to antidepressant therapy: A nationwide population-based study

Progestin-only contraceptive users resorted to antidepressants more than users of CHCs among teenagers, particularly pronounced among teenagers: special attention should be given to young women's mental history when prescribing hormonal contraceptives and vice versa.

Association of Use of Oral Contraceptives With Depressive Symptoms Among Adolescents and Young Women.

Although oral contraceptive use showed no association with depressive symptoms when all age groups were combined, 16-year-old girls reported higher depressive symptom scores when using oral contraceptives, suggesting they are at risk for nonadherence.

Counteracting side effects of combined oral contraceptives through the administration of specific micronutrients.

Considering the wide use of OCs, taking appropriate dietary supplements could be an effective approach in clinical practice, tailoring therapies and improving both safety and tolerability.
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23 References

Depressive Symptoms and Oral Contraceptives

Women taking a contraceptive containing lynoestrenol 2·5 mg.

Depression associated with combined oral contraceptives--a pilot study.

The authors onducted a pilot study using well validated depression rating scales to determine and quantify depression symptoms in women using oral contraceptives.

Oral contraceptives--an update.

Four decades after introduction of the pill, more women than ever are using it. Today's low-dose oral contraceptives are safer and just as effective as earlier pills. Taken regularly, the pill…

Clinical criticism of the oral contraceptive pills.

A physician's experience with complications associated with oral contraceptive (OC) use is presented and the importance of maintaining records on complications encountered during oral contraceptive use for future study is emphasized.

Psychiatric symptoms during the post-partum period as related to use of oral contraceptives.

There was a significantly higher frequency of psychiatric symptoms in the group taking the pill during the postpartum period and in sexual adaptation there was a greater tendency for greater fluctuation in the pill group toward both improvement and impairment.

Relationship between premenstrual symptoms and oral contraceptive use: a controlled study.

For most subjects, the cyclical changes were relatively mild, and these findings need to be replicated in women suffering from severe premenstrual syndrome, however, alternative explanations need to account for changes in women both taking and not taking oral contraceptives.

Oral contraception and cyclic changes in premenstrual and menstrual experiences

‘healthy women’ using OC experience premenstrual and menstrual changes, and any differences between OC formulations are subtle and not of clinical significance in ‘healthyWomen’ already established on monophasic or triphasic hormonal contraception.

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