Treatment of Neurological Manifestations of Gluten Sensitivity and Coeliac Disease

@article{Zis2019TreatmentON,  title={Treatment of Neurological Manifestations of Gluten Sensitivity and Coeliac Disease},  author={Panagiotis Zis and Marios Hadjivassiliou},  journal={Current Treatment Options in Neurology},  year={2019},  volume={21},  pages={1-10},  url={https://api.semanticscholar.org/CorpusID:73466457}}
Strict gluten-free diet is an effective first-line treatment of the neurological manifestations of gluten-related disorders and very few patients will require additional immunosuppressive treatment usually in the form of mycophenolate.

46 Citations

Gluten-Associated Neurological Disorders: A Cases Series

For many patients with neurological presentations who initially lack gastrointestinal symptoms, diagnosis remains challenging, and while a gluten-free diet has been the mainstay of treating GAND for many years, this approach may only prevent progression of disease without reversal of symptoms.

Neurological manifestation of coeliac disease with particular emphasis on gluten ataxia and immunological injury: a review article

This review will touch on the salient features of CD and the nervous system and will highlight current controversies in relation to gluten and GA.

Autoantibodies related to ataxia and other central nervous system manifestations of gluten enteropathy

This narrative review focuses on the various neuro-logical manifestations in patients with gluten sensitivity/celiac disease, immunological and autoimmune mechanisms of ataxia in connection to gluten sensitivity and the autoantibodies that could be used as a biomarker for diagnosing and following.

Extraintestinal complications of celiac disease: treatment considerations

This review, based on a Pubmed literature search, describes the extraintestinal complications associated with CD, emphasizing strategies for therapeutic management and responsiveness to the GFD.

Neurological Manifestations of Celiac Disease and Non-Celiac Gluten Sensitivity and the Effect of a Gluten Free Diet

This study seeks to review the evidence regarding the neurological manifestations of CeD, the effect of a gluten-free diet, and highlight studies investigating NCGS/NCWS as a distinct entity from CeD.

Associations between Celiac Disease, Extra-Gastrointestinal Manifestations, and Gluten-Free Diet: A Narrative Overview

This narrative overview is aimed at characterizing diseases and complaints that are associated with unrecognized CeD and that frequently involve sites other than the gastrointestinal tract, i.e., dental, otorhinolaryngological, and ocular complications.

Psychiatric and Neurological Manifestations of Celiac Disease in Adults

The most recent psychiatric data as they pertain to CD, as well as the relevant psychiatric manifestations that have been associated with this condition, are looked at.

Gluten neuropathy: prevalence of neuropathic pain and the role of gluten-free diet

Strict gluten-free diet might be protective as it is associated with a significant reduction of the odds of peripheral neuropathic pain associated to GN, and is related with poorer mental health status.

Coeliac disease and noncoeliac wheat or gluten sensitivity

It is unclear which components of wheat are responsible for symptom generation in noncoeliac wheat or gluten sensitivity, with further research required to elucidate the pathophysiology.

48 References

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This review highlights that the phenomenology of gluten related MDs is broader than GA and demonstrates that gluten-free diet (GFD) is beneficial in a great percentage of such cases.

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The experience with 13 patients who presented with symptoms and signs suggestive of a myopathy and in whom investigation led to the diagnosis of gluten sensitivity shows clinical improvement of the myopathy with a gluten‐free diet.

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Patients with epilepsy of unknown aetiology should be investigated for serological markers of gluten sensitivity as such patients may benefit from a GFD, according to the data.

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