Gabapentin or pregabalin induced myoclonus: A case series and literature review

@article{Desai2019GabapentinOP,  title={Gabapentin or pregabalin induced myoclonus: A case series and literature review},  author={Aaron Desai and Yazan Kherallah and Cheryl Szabo and Rohit Marawar},  journal={Journal of Clinical Neuroscience},  year={2019},  volume={61},  pages={225-234},  url={https://api.semanticscholar.org/CorpusID:53165515}}

24 Citations

Presumed gabapentin-induced myoclonus in two cats

Clinicians should be aware of the potential for this phenomenon in cats receiving recommended doses of gabapentin, and future studies should focus on the role of chronic kidney disease and other neurologic conditions as risk factors for development of this condition.

Gabapentin-induced Multifocal Myoclonus.

Acute hyperkinetic movement disorders such as multifocal or segmental myoclonus in elderly patients warrant a prompt review of recent drug history, especially gabapentin, even in the background of normal renal function.

Amantadine Associated Myoclonus: Case Report and Review of the Literature

An 80-year-old man with Parkinson's disease diagnosed in 2015 was started on amantadine for treatment of progressive tremor and orofacial dyskinesias induced by levodopa and showed diffuse myoclonus throughout his extremities and trunk, as well as asterixis when attempting to stand or holding his arms antigravity.

Seizures as an Adverse Effect of Pregabalin Consumption: A Systematic Review

PGBIS was more commonly reported in females, patients who consumed high doses of PGB, patients who ingested multiple drugs, patients who ingested multiple drugs, and patients with renal insufficiency, while the dosages used for therapeutic purposes were much lower than in the other two groups.

Gabapentin-Associated Movement Disorders: A Literature Review

Myoclonus and dyskinesia were the most common movement disorders associated with Gabapentin-induced movement disorders, and the management of GBP-associated MD involved GBP discontinuation.

Pregabalin-associated movement disorders: A literature review

In the literature, the majority of the cases did not report information about timeline events, neurological examination details, or electrodiagnostic studies, so the best management for all MDs is probably PGB withdrawal.

Extracorporeal Treatment for Gabapentin and Pregabalin Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup.

The EXTRIP workgroup suggests against performing ECTR in addition to standard care rather than standard care alone (weak recommendation, very low quality of evidence) for gabapentinoid poisoning in patients with normal kidney function.

Evaluation of Gabapentin and Pregabalin Use in Hospitalized Patients With Decreased Kidney Function

The relationship between gabapentinoid dosing, kidney function, and the incidence of gabapentinoid-related AEs at hospital admission requires larger, multicentre studies.

Immediate and controlled-release pregabalin for the treatment of epilepsy

PGB CR failed to prove superior to placebo in a randomized placebo-controlled trial on 323 subjects with drug-resistant FOE, although it was just as tolerable, and is not currently licensed for epilepsy.

36 References

Myoclonus induced by the use of gabapentin.

A 69-year-old female who underwent diskectomy and foraminotomy and postoperatively complained of paresthesia in her left leg, which was thought to be due to root manipulation during surgery, was given tramadol, an oral opioid agonist, and GBP.

Pregabalin-associated myoclonic encephalopathy without evidence of drug accumulation in a patient with acute renal failure

Pregabalin-induced myoclonus may not be strictly related to drug accumulation in acute renal failure, with the possibility of a threshold phenomenon, and patients with impaired renal function are at risk to develop more serious adverse events.

Myoclonus: Pathophysiology and Treatment Options

Deep brain stimulation targeting the globus pallidus pars-interna bilaterally has been used in myoclonus-dystonia when pharmacological treatments have been exhausted.

The clinical heterogeneity of drug-induced myoclonus: an illustrated review

The high number of cases of drug-induced myoclonus, together with their reported heterogeneous clinical characteristics, underscores the importance of considering drugs as a possible cause of myoc Lonus, regardless of its clinical characteristics.

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