Transdermal Scopolamine: An Alternative to Ondansetron and Droperidol for the Prevention of Postoperative and Postdischarge Emetic Symptoms

@article{White2007TransdermalSA,  title={Transdermal Scopolamine: An Alternative to Ondansetron and Droperidol for the Prevention of Postoperative and Postdischarge Emetic Symptoms},  author={Paul F. White and Jun Tang and Dajun Song and Jayne E. Coleman and Ronald H. Wender and Babatunde O. Ogunnaike and Alexander Sloninsky and Rajani Kapu and Mary Shah and Thomas Webb},  journal={Anesthesia \& Analgesia},  year={2007},  volume={104},  pages={92-96},  url={https://api.semanticscholar.org/CorpusID:44784425}}
Premedication with TDS was as effective as droperidol (1.25 mg) or ondansetron (4 mg) in preventing nausea and vomiting in the early and late postoperative periods, however, the use of a TDS patch is more likely to produce a dry mouth.

Tables from this paper

65 Citations

Use of a Disposable Acupressure Device as Part of a Multimodal Antiemetic Strategy for Reducing Postoperative Nausea and Vomiting

Use of the Pressure Right acupressure device in combination with antiemetic drugs provided a reduction in the incidence of vomiting from 0 to 72 hours after surgery with an associated improvement in patient satisfaction with their PONV management, but recovery and outcome variables failed to demonstrate any improvement with the addition of the acupressesure device.

The effect of transdermal scopolamine for the prevention of postoperative nausea and vomiting

Transdermal scopolamine is a promising candidate for the management of PONV in adults as a first line monotherapy or in combination with other drugs and might be helpful in preventing postoperative discharge nausea and vomiting owing to its long-lasting clinical effects.

Effect of intravenous scopolamine before stapling, on postoperative nausea and vomiting in sleeve gastrectomy patients: a randomized controlled trial

It is concluded that incidence of PONV in obese patients undergoing LSG is not affected by scopolamine, and further trials are needed to validate the results.

Revisiting transdermal scopolamine for postoperative nausea and vomiting

Transdermal scopolamine is easy to administer, safe, effective, and relatively cost-effective, and it should be considered as an important tool to help prevent PONV/PDNV, whether administered as monotherapy or in combination with other agent(s).
...

13 References

Double–blind comparison of transdermal scopolamine, droperidol and placebo against postoperative nausea and vomiting

It is concluded that prophylactic transdermal scopolamine does not diminish postoperative emetic sequelae and its antiemetic effect with intravenous droperidol (DHBP), the authors' routine antidote for postoperativeEmesis.

Transdermal scopolamine reduces nausea and vomiting after outpatient laparoscopy.

Transdermal scopolamine is a safe and effective antiemetic for outpatients undergoing laparoscopy in a double-blind, placebo-controlled study.

The Efficacy and Safety of Transdermal Scopolamine for the Prevention of Postoperative Nausea and Vomiting: A Quantitative Systematic Review

The role of scopolamine administered via transdermal therapeutic systems in the prevention of postoperative vomiting, nausea, and nausea and vomiting is unclear and the timing of application does not alter efficacy.

Premedication with promethazine and transdermal scopolamine reduces the incidence of nausea and vomiting after intrathecal morphine

The effect of different premedications on postoperative emetic sequelae induced by intrathecal morphine was studied in a prospective, double blind study of arthroplasty surgery of the lower extremity.

Increased incidence of retching and vomiting during periovulatory phase after middle ear surgery

The incidence of R&V after middle ear surgery was lower during the perimenstrual phase and transdermal scopolamine was more efficient as prophylaxis against R& V than ondansetron in the periovulatory phase.

Effect of transdermal hyoscine on nausea and vomiting after surgical correction of prominent ears under general anaesthesia.

In the placebo group more patients (48%) needed droperidol as an antiemetic compared with the hyoscine group (16%; P < 0.05), and there was significantly more sedation in the hyoscope group.

Transdermal Scopolamine in Motion Sickness

A new system of drug delivery, the transdermal therapeutic system (TTS) — Transderm®‐V — has been developed, which permits a drug with a very short half life to be administered over prolonged periods, thereby maintaining blood concentrations at the defined therapeutic level.

Prevention of postoperative nausea and vomiting--a multimodal solution to a persistent problem.

Despite the introduction of new antiemetic agents, short-acting anesthetics, and minimally invasive surgical techniques, the incidence of postoperative nausea and vomiting has remained largely unch...

A Postanesthetic Recovery Score

Ten years ago, Virginia Apgarl first proposed her new method of evaluation of neonates, which remains the simplest and perhaps most reliable manner to objectively describe the physical condition of the infant at birth.

Related Papers

Showing 1 through 3 of 0 Related Papers