The mouse ascending: perspectives for human-disease models

@article{Rosenthal2007TheMA,  title={The mouse ascending: perspectives for human-disease models},  author={Nadia A. Rosenthal and Steve D. M. Brown},  journal={Nature Cell Biology},  year={2007},  volume={9},  pages={993-999},  url={https://api.semanticscholar.org/CorpusID:4472227}}
The recent launch of several international initiatives to analyse the function of all mouse genes through mutagenesis, molecular analysis and phenotyping underscores the utility of the mouse for translating the information stored in the human genome into increasingly accurate models of human disease.

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34 References

The mouse as a model for human biology: a resource guide for complex trait analysis

This review summarizes resources of mouse resource infrastructure and provides practical guidelines for their use, particularly in the analysis of quantitative traits.

Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease

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Animal models of human disease: zebrafish swim into view

This Review surveys the achievements and potential of zebrafish for modelling human diseases and for drug discovery and development.

Understanding Mammalian Genetic Systems: The Challenge of Phenotyping in the Mouse

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Genetic variation in laboratory mice

Recent studies that have contributed to an emerging understanding of the unique variation patterns found in inbred strains of mice and how they have arisen through a combination of natural evolution and human-directed breeding are discussed.

The European dimension for the mouse genome mutagenesis program

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Humanized mice in translational biomedical research

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