Systematic review and meta‐analysis of outcomes following emergency surgery for Clostridium difficile colitis

@article{Bhangu2012SystematicRA,  title={Systematic review and meta‐analysis of outcomes following emergency surgery for Clostridium difficile colitis},  author={Aneel Bhangu and Dmitri Nepogodiev and Anurag Gupta and Andrew W. Torrance and Prashant Singh},  journal={British Journal of Surgery},  year={2012},  volume={99},  url={https://api.semanticscholar.org/CorpusID:42729589}}
The aim of this study was to describe the operations performed and to identify factors predictive of death following emergency surgery for CDI.

148 Citations

Review article: The epidemiology and management of Clostridioides difficile infection—A clinical update

Clostridioides difficile is the most common cause of healthcare‐associated infection, and severe cases can result in significant complications, and adjunctive therapies may be utilised as preventative strategies.

Diagnosis and Management of Clostridium difficile Infection (CDI)

Infection due to Clostridium difficile is a prevalent cause of morbidity and mortality in the intensive care unit. Appropriate diagnosis and treatment of CDI remains challenging in the face of new…

Surgical Management of Clostridium difficile Infection: The Role of Colectomy.

The role of colectomy is reviewed and surgical therapy is critical to eradication of the inflammatory process and reversal of the dysregulated immunity associated with severe C. difficile infections.

Timing and type of surgical treatment of Clostridium difficile–associated disease: A practice management guideline from the Eastern Association for the Surgery of Trauma

It is strongly recommend that adult patients with CDAD undergo early surgery, before the development of shock and need for vasopressors, and the quality of evidence was rated “very low.”

Risk factors for short‐ and long‐term mortality in very old patients with Clostridium difficile infection: A retrospective study

Most cases of Clostridium difficile infections (CDI) occur in patients aged 65 years and older. Older age is associated with increased mortality. Risk factors for mortality in patients aged 80 years…

WSES guidelines for management of Clostridium difficile infection in surgical patients

An international multidisciplinary panel of experts prepared evidenced-based World Society of Emergency Surgery (WSES) guidelines for management of CDI in surgical patients.

Organ-Preserving Strategies in the Management of Fulminant Clostridium difficile Colitis

Given the importance of early intervention and reduction in surgical stress, minimally invasive colon preserving therapies and non-operative interventions have emerged as attractive options.

Methodological overview of systematic reviews to establish the evidence base for emergency general surgery

The quantity and quality of systematic review evidence for the most common emergency surgical conditions are reviewed and treatment decision‐making in emergency general surgery is summarized.

Diverting Loop Ileostomy for Clostridium Difficile Colitis: A Systematic Review and Meta-analysis

Loop ileostomy may be a viable surgical alternative to total colectomy with similar mortality; however, further work is needed to determine specific patient characteristics that warrant routine use of DLI.
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Identification of a set of preoperative characteristics that could predict outcome after surgery is necessary to optimize clinical management and guide surgical timing and identified factors can predict unfavorable outcomes after colectomy.

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Early or pre-operative microbiological diagnosis of C. difficile infection can be difficult in patients with a fulminant presentation, and patients with C. Difficile colitis, who develop signs of toxicity, peritonitis or perforation, should undergo a total colectomy as the operation of choice.

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