The extra-hypothalamic actions of ghrelin on neuronal function

@article{Andrews2011TheEA,  title={The extra-hypothalamic actions of ghrelin on neuronal function},  author={Zane B. Andrews},  journal={Trends in Neurosciences},  year={2011},  volume={34},  pages={31-40},  url={https://api.semanticscholar.org/CorpusID:42200775}}

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103 References

Ghrelin induces adiposity in rodents

It is proposed that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary, suggesting an involvement in regulation of energy balance.

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.

It is shown that in mice and rats, ghrelin bound to neurons of the VTA, where it triggered increased dopamine neuronal activity, synapse formation, and dopamine turnover in the nucleus accumbens in a GHSR-dependent manner, suggesting that the mesolimbic reward circuitry is targeted by peripheral gh Relin to influence physiological mechanisms related to feeding.

A Role of Ghrelin in Neuroendocrine and Behavioral Responses to Stress in Mice

The findings suggest that ghrelin may have a role in mediating neuroendocrine and behavioral responses to stressors and that the stomach could play an important role, not only in the regulation of appetite, but also in theregulation of anxiety.

Role of the ghrelin system in alcoholism: Acting on the growth hormone secretagogue receptor to treat alcohol-related diseases.

These findings suggest that the ghrelin system plays a role in alcohol dependence, and suggests that GHS-R1a antagonists and/or inverse agonists might affect alcohol-seeking behavior, thus having therapeutic potential in alcohol use disorders.

Ghrelin Promotes and Protects Nigrostriatal Dopamine Function via a UCP2-Dependent Mitochondrial Mechanism

The data reveal that peripheral ghrelin plays an important role in the maintenance and protection of normal nigrostriatal dopamine function by activating UCP2-dependent mitochondrial mechanisms and the potential implications of these studies on the link between obesity and neurodegeneration.

Association of pro-ghrelin and GHS-R1A gene polymorphisms and haplotypes with heavy alcohol use and body mass.

The present findings are the first to disclose an association between the pro-ghrelin and GHS-R1A genes and heavy alcohol use, further strengthening the role of the ghrelin system in addictive behaviors and brain reward.
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