Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

@article{Shimizu1982OrganizationOT,  title={Organization of the constant-region gene family of the mouse immunoglobulin heavy chain},  author={Akira Shimizu and Naoki Takahashi and Yoshio Yaoita and Tasuku Honjo},  journal={Cell},  year={1982},  volume={28},  pages={499-506},  url={https://api.semanticscholar.org/CorpusID:42076631}}

258 Citations

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46 References

Complete nucleotide sequence of mouse immunoglobulin mu gene and comparison with other immunoglobulin heavy chain genes.

The results implicate that the nucleotide sequence of the intervening sequence is under selective pressure, possibly to maintain a secondary structure of the nuclear RNA to be spliced, and implicates that the class of the immunoglobulinheavy chain genes diverged after the heavy chain genes established the multi-domain structure.

Exon shuffling generates an immunoglobulin heavy chain gene.

A model suggesting how the phenomenon of switch seen in lymphocytes may occur is presented, suggesting that at least two recombination events occurred to create the gamma 2b gene in MOPC 141.

J genes for heavy chain immunoglobulins of mouse.

A 15,8-kilobase pair fragment of BALB/c mouse liver DNA, cloned in the Charon 4A lambda phage vector system, was shown to contain the mu heavy chain constant region (CHmu) gene for the mouse…

DNA sequences mediating class switching in alpha-immunoglobulins.

The lack of homology between this C alpha sequence and sequences reported for the C gamma 1 and C gamma 2b switch sites suggests that heavy chain switching is mediated by class-specific recognition sequences and, presumably, class- specific regulatory mechanisms.

Rearrangements of Immunoglobulin Genes during Differentiation and Evolution

Comparison of nucleotide sequences of CH genes indicates that immunoglobulin genes have scrambled by intervening sequence-mediated domain transfer during their evolution.

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