Identification of Phenazocine, a Potent New Analgesic

@article{Clarke1959IdentificationOP,  title={Identification of Phenazocine, a Potent New Analgesic},  author={Edward de Couray Clarke},  journal={Nature},  year={1959},  volume={184},  pages={451-451},  url={https://api.semanticscholar.org/CorpusID:4190489}}
The synthesis of a new analgesic of remarkable potency, phenazocine (2-hydroxy-5,9-dimethyl-2-phenethyl-6,7-benzomorphan), has recently been announced and is now undergoing clinical trials in the United States.
8 Citations

8 Citations

Phenazocine hydrobromide: pharmaceutical aspects of a new benzomorphan analgesic related to morphine.

Some chemical and physical properties of phenazocine hydrobromide are presented, including X-ray diffraction data and infrared curves on three known crystalline forms. A schematic representation of a…

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Eight interesting reactions using naltrexone derivatives are described, which can lead to the synthesis of many novel skeletons that provide new interesting pharmacological data.

ANALGESIA AND ADDICTION.

It is an unfortunate fact that the potent drugs which produce analgesia are concomitantly addicting, i.e. that they produce physical and psychic dependence as well as exhibiting the phenomenon of tolerance development.

5 References

A NOTE ON THE IDENTIFICATION OF SOME ANTIMALARIAL DRUGS

    E. C. Clarke
    Medicine
    The Journal of pharmacy and pharmacology
  • 1958
Primaquine (Avlon, 6-methoxy8-(4-amino1 -methylbutylamino) quinoline diphosphate) Pentaquine (6-methoxy-8-(5-isopropylaminoamylamino) quinoline phosphate) Isopentaquine…

Paper Chromatographic Examination of the Alkaloid Extract in Toxicology

RECENT advances in chemotherapy present the police toxicologist with the problem of extracting and identifying from viscera an increasing number of basic organic compounds. In the past, methods of…

MICROCHEMICAL TESTS FOR THE IDENTIFICATION OF ALKALOIDS

The technique described below has been introduced for the identification of alkaloids when only a few pg.

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