DOI:10.1038/135591A0 - Corpus ID: 4121225
X-Ray Single Crystal Photographs of Insulin
@article{Crowfoot1935XRaySC, title={X-Ray Single Crystal Photographs of Insulin}, author={Dorothy Crowfoot}, journal={Nature}, year={1935}, volume={135}, pages={591-592}, url={https://api.semanticscholar.org/CorpusID:4121225}}- D. Crowfoot
- Published inNature13 April 1935
- Chemistry, Medicine
The fact that pepsin could be made to give a single crystal X-ray diffraction pattern suggested that the problem of insulin, which is in many respects a more stable crystalline species, could be attacked in the same way if large enough crystals could be grown.
87 Citations
The Two Crystalline Modifications of Insulin
- D. Crowfoot
- 1937
Medicine
X-ray examination of Abel's crystalline insulin showed the presence of two types of insulin crystals, the so-called prismatic or needle variety and the more common variety, which are those obtained first by Abel from phosphate buffers at pH 6.2.
Crystallographic Measurements and the Structure of Protein Molecules as They Are
- D. Hodgkin
- 1979
Biology, Chemistry
A brief account of the history and prehistory of protein crystallography that determined the authors' thinking in the thirties and forties is proposed.
Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by
- T. BlundellG. DodsonD. HodgkinD. Mercola
- 1972
Chemistry, Medicine
Insulin crystallization in the presence of basic proteins and peptides.
- W. W. FullertonB. W. Low
- 1970
Chemistry, Medicine
EVIDENCE FROM X‐RAYS REGARDING THE STRUCTURE OF PROTEIN MOLECULES
- I. Fankuchen
- 1941
Chemistry, Biology
A critical examination of the techniques and data should show where assumfiions enter and by making clearer the distinction between fact and theory help put the X-ray study of proteins on a sounder basis.
The structure of 2Zn pig insulin crystals at 1.5 A resolution.
- E. BakerT. BlundellNumminate M. Vijayan
- 1988
Medicine, Chemistry
The paper describes the arrangement of the atoms within rhombohedral crystals of 2Zn pig insulin as seen in electron density maps calculated from X-ray data extending to 1.5 A at room temperature and refined to R = 0.153, finding all but eight of the active atoms in the protein form at least one hydrogen bond.
Electron Paramagnetic Resonance in Single Crystals of Cupric Insulin
- A. S. BrillJ. Venable
- 1964
Chemistry
The application of electron paramagnetic resonance (EPR) spectroscopy to the binding of divalent metal ions to insulin is described and the richness of the data obtainable from orientation investigations of single crystals is emphasized.
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5 References
X-Ray Photographs of Crystalline Pepsin
- J. D. BernalD. Crowfoot
- 1934
Chemistry
FOUR weeks ago, Dr. G. Millikan brought us some crystals of pepsin prepared by Dr. Philpot in the laboratory of Prof. The Svedberg, Uppsala. They are in the form of perfect hexagonal bipyramids up to…
CRYSTALLINE INSULIN
- John J. AbilHopins UnivzrsityJ. J. Abel
- 2005
Chemistry
The conclusions of this paper remain substantially unchanged and can be applied equally as well to the reaction between ozone and carbon monoxide, if this reaction be thought responsible for the luminescence.
Phenomena in a Sounding Tube.
- E. Andrade
- 1931
Medicine, Physics
Results of research into the phenomena which occur in a sounding tube are obtained, publication of which will shortly take place, having been delayed by illness.
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