Increased Expression of the Relaxin Receptor (LGR7) in Human Endometrium during the Secretory Phase of the Menstrual Cycle

@article{Bond2005IncreasedEO,  title={Increased Expression of the Relaxin Receptor (LGR7) in Human Endometrium during the Secretory Phase of the Menstrual Cycle},  author={Courtney Peta Bond and Laura J. Parry and Chrishan S. Samuel and Helen M. Gehring and Fiona L. Lederman and Peter A. W. Rogers and Roger J. Summers},  journal={Annals of the New York Academy of Sciences},  year={2005},  volume={1041},  url={https://api.semanticscholar.org/CorpusID:38242216}}
The increase in LGR7 expression and H2 relaxin binding in the secretory phase of the menstrual cycle suggests a specific role for relaxin after ovulation in the human uterus.
4 Citations

4 Citations

Angiogenic effects of norplant contraception on endometrial histology and uterine bleeding.

The expression of this angiogenic protein, particularly in the stromal and perivascular compartments, correlated with microvascular density, hysteroscopically documented hypervascularity, and uterine bleeding profiles.

Relaxin: A missing link in the pathomechanisms of Systemic Lupus Erythematosus?

A potential role for uterine endometrium through its production of relaxin, a peptide hormone, as a “missing-link” to explain this female predominance, variable clinical course and obstetric complications operating in SLE is hypothesized.

46 References

Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle.

The increase in LGR7 expression and H2 relaxin binding in the secretory phase of the menstrual cycle suggests a specific role for relaxin after ovulation in the human uterus.

Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle.

It is concluded that no consistent regulation of LGR7 mRNA expression can be detected in human endometrium during the menstrual cycle, and a large degree of variation in LGR6 mRNA expression levels between patients is observed.

Characterization of relaxin binding in the uterus of the marmoset monkey.

In the marmoset monkey, the pattern of specific binding closely reflects the RLX-dependent physiology during implantation and early pregnancy, implying the probable involvement of a specific RLX receptor.

Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women.

The results suggest that relaxin, which is secreted by the corpus luteum and is present in the endometrium during the menstrual cycle and pregnancy, may be involved in regulating endometrial VEGF expression.

Relaxin stimulates glycodelin mRNA and protein concentrations in human endometrial glandular epithelial cells.

To investigate whether relaxin regulates the GdA synthesis, human endometrial glandular epithelial cells were isolated and cultured with or without relaxin for up to 4 days, and mRNA concentrations increased 2-11-fold in cells incubated with relaxin, indicating that relaxin activates Gd a transcription.

Reproductive Biology and Endocrinology Immunoexpression of the Relaxin Receptor Lgr7 in Breast and Uterine Tissues of Humans and Primates

Specific monotypic antibodies have been generated and applied to a preliminary analysis of human and primate female reproductive tissues to characterize both in vivo and in vitro expression of the receptor for the peptide hormone relaxin.

Relaxin Gene and Protein Expression and Its Regulation of Procollagenase and Vascular Endothelial Growth Factor in Human Endometrial Cells1

It is demonstrated that human endometrial cells synthesize relaxin, and this data support the concept that relaxin fostersendometrial conditions that are required for implantation in women.

Identification of specific relaxin-binding cells in the human female.

It is concluded that the specific relaxin-binding cells probably contain Relaxin receptors, and Identification of putative relaxin receptors may provide insight into physiological and/or therapeutic roles of relaxin in the human.

Related Papers

Showing 1 through 3 of 0 Related Papers