Interneurons of the neocortical inhibitory system

@article{Markram2004InterneuronsOT,  title={Interneurons of the neocortical inhibitory system},  author={Henry Markram and Maria Toledo-Rodriguez and Yun Wang and Anirudh Gupta and Gilad Silberberg and Caizhi Wu},  journal={Nature Reviews Neuroscience},  year={2004},  volume={5},  pages={793-807},  url={https://api.semanticscholar.org/CorpusID:382334}}
This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits.

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177 References

Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex.

It is suggested that inhibitory synapses could shape the impact of different interneurons according to their specific spatiotemporal patterns of activity and that GABAergic interneuron and synapse diversity may enable combinatorial inhibitory effects in the neocortex.

Local circuits in primary visual cortex of the macaque monkey.

The basic laminar organization of excitatory local circuitry in the primary visual cortex of the macaque monkey is similar to that described previously in the cat's visual cortex, but within this basic framework is a more complex organization.

Interneurons unbound

This review brings together recently described properties and emerging principles of interneuron function that indicate a much more complex role for these cells than just providers of inhibition.

Anatomical organization of macaque monkey striate visual cortex.

I hope that this review of the internal anatomy of the monkey primary visual cortex makes clear the high degree of specialization that exists in each of the cortical laminae and their constituent

Network of GABAergic large basket cells in cat visual cortex (area 18): Implication for lateral disinhibition

The topographical and synaptic relationship between identified GABAergic large basket cells and their immunohistochemically characterized target neurons revealed by parvalbumin‐(PV) and GABA immunostaining in the same material is studied.

Dynamics of population rate codes in ensembles of neocortical neurons.

This work combines theoretical analysis and whole cell recordings to show that encoding signals in the variance of uncorrelated synaptic inputs to a neocortical ensemble enables faithful transmission of graded signals with high temporal resolution.

Synaptic dynamics control the timing of neuronal excitation in the activated neocortical microcircuit

This work proposes that synaptic dynamics choreograph neuronal activity within the neocortical microcircuit in a context‐dependent manner and shows that patterned activity is essential for synaptic dynamics to impose the temporal dispersion of excitatory input.

Circuitry, architecture, and functional dynamics of visual cortex.

It has become increasingly possible to relate the responsive specificity of cortical cells, and the circuitry underlying this specificity, to the perceptual capabilities of the visual system by performing analogous experiments on single cells and in human psychophysics.
...

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