Tibolone is not aromatized in postmenopausal women

@article{Hj2008TiboloneIN,  title={Tibolone is not aromatized in postmenopausal women},  author={Kloosterboer Hj},  journal={Climacteric},  year={2008},  volume={11},  pages={175 - 176},  url={https://api.semanticscholar.org/CorpusID:203781220}}
The conclusions of the study were that the THEBES results confirm previous findings that tibolone does not induce endometrial hyperplasia or carcinoma in postmenopausal women, and it is associated with a better vaginal bleeding profile than conjugated equine estrogens/medroxyprogesterone acetate.
6 Citations

6 Citations

Recent advances on the action of estrogens and progestogens in normal and pathological human endometrium

Treatment with hormone replacement therapy (estrogens+progestogens), as well as with tibolone, is most effective in protecting this tissue by climacteric alterations, owing to the significant decrease of ovarian hormones.

Vascular resistance of central retinal and ophthalmic arteries in postmenopausal women after use of tibolone

It is demonstrated that tibolone administration to healthy postmenopausal women does not affect the resistance of small-caliber cerebral arteries and is compared with placebo using transorbital ultrasound with Doppler velocimetry.

[Tibolone's effect on retinal and ophthalmic arteries flowmetry].

In both groups, the women's characteristics were similar in age, menopause duration, body mass index, arterial blood pressure, deliveries and cardiac rate, and the tibolone and control groups did not show any significant difference in regard to the above indexes in the end of the study.

Hyperglycemia in postmenopausal women screened for the metabolic syndrome is associated to increased sexual complaints

Despite the limitations of this study, as assessed with the MENQOL, hyperglycemia in postmenopausal women screened for the METS was associated to a negative impact in sexuality.

Quality of life impairment during the female menopausal transition is related to personal and partner factors

A high rate of middle-aged women in this series presented impaired QoL associated to female age and hormonal status and additionally to partner's health and sexual behavior, and logistic regression analysis determined that female age, menopause and partnerocious ejaculation increased the risk for presenting higher total MRS scores (impaired femaleQoL), whereas HT use, church assistance and partner faithfulness decreased this risk.

Quality of life impairment among postmenopausal women varies according to race

Menopausal symptoms in indigenous (urogenital) and black (somatic/psychological) women were more severe (impaired QoL) when compared to Hispanic ones, while black women presented higher MRS psychological and somatic scorings than Hispanic and indigenous women.

7 References

Can 19-nortestosterone derivatives be aromatized in the liver of adult humans? Are there clinical implications?

19-nortestosterone derivatives (norethisterone, norethynodrel, tibolone) can readily be aromatized in the adult human liver, which leads to the formation of the potent estrogens ethinylestradiol from norehisterone or nore fourthodrel and 7α-methyl-ethinylest radiol from tibiaolone.

Formation of 7&agr;-methyl-ethinyl estradiol during treatment with tibolone

Investigation of whether tibolone, which is orally used for hormone replacement therapy, is transformed to a derivative of ethinyl estradiol (EE), demonstrates that, during daily treatment of women with 2.5 mg tiblone, a small proportion of tIBolone is transformation to 7&agr;-methyl-EE.

7&agr;-Methyl-ethinyl estradiol is not a metabolite of tibolone but a chemical stress artifact

7&agr;-MEE is not a metabolite of tibolone but is a chemical artifact generated during analytical procedures with derivatization, and cannot be demonstrated in plasma from postmenopausal women after single or multiple doses of tIBolone.

Conversion of tibolone to 7&agr;-methyl-ethinyl estradiol using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry: interpretation and clinical implications

The findings prove that conversion of tibolone to MEE is an artifact that is generated in a GC- MS system and is largely due to the intense heating step involved in GC-MS.

Endometrial effects of tibolone.

The Tibolone Histology of the Endometrium and Breast Endpoints Study results confirm previous findings that tibolone does not induce endometrial hyperplasia or carcinoma in postmenopausal women, and it is associated with a better vaginal bleeding profile than CEE/MPA.

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