Manifestation of severe coronary heart disease after anabolic drug abuse

@article{Mewis1996ManifestationOS,  title={Manifestation of severe coronary heart disease after anabolic drug abuse},  author={Christian Mewis and Ioakim Spyridopoulos and Volker K{\"u}hlkamp and Ludger Seipel},  journal={Clinical Cardiology},  year={1996},  volume={19},  url={https://api.semanticscholar.org/CorpusID:37024092}}
A young bodybuilder who presented with ventricular tachycardia as the first manifestation of severe underlying coronary heart disease is reported on, with possible atherogenic consequences of long‐term abuse of stanazolol.

58 Citations

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18 References

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Young patients entering the hospital have an excellent 1 year prognosis, but those with prior infarction in whom there are selected abnormal findings at hospital discharge comprise a subgroup that may benefit from early aggressive management.

The effect of anabolic-androgenic steroids on primary myocardial cell cultures.

The concentration- and time-dependent effects of testosterone cypionate (TC), stanozolol (S), and fluoxymesterone (F) on primary myocardial cell cultures were described and cellular injury was evaluated by alterations in beating activity, induction of morphological alterations, lactate dehydrogenase (LDH) release, neutral red retention, and tetrazolium (MTT) formazan production.

Stanozolol and experimental atherosclerosis: atherosclerotic development and blood lipids during anabolic steroid therapy of New Zealand white rabbits.

No significant influence of the anabolic steroid stanozolol either on the extent of atherosclerotic involvement or on HDL or LDL cholesterol is found.

Contrasting effects of testosterone and stanozolol on serum lipoprotein levels.

It is concluded that the undesirable lipoprotein effects of 17-alpha-alkylated steroids given orally are different from those of parenteral testosterone and that the latter may be preferable in many clinical situations.

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The results of this study suggest that the sustained use of testosterone and anabolic steroids have a marked unfavorable effect on the pattern of HDL cholesterol in the serum of male power athletes.

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