Role of Prostaglandin D Receptor CRTH2 in Sustained Eosinophil Accumulation in the Airways of Mice with Chronic Asthma

@article{Kagawa2011RoleOP,  title={Role of Prostaglandin D Receptor CRTH2 in Sustained Eosinophil Accumulation in the Airways of Mice with Chronic Asthma},  author={Shizuko Kagawa and Koichi Fukunaga and Tsuyoshi Oguma and Yusuke Suzuki and Tetsuya Shiomi and Koichi Sayama and Tokuhiro Kimura and Hiroyuki Hirai and Kin-ya Nagata and Masataka Nakamura and Koichiro Asano},  journal={International Archives of Allergy and Immunology},  year={2011},  volume={155},  pages={6 - 11},  url={https://api.semanticscholar.org/CorpusID:34914925}}
CRTH2 that mediates PGD2 activity is essential for sustained eosinophilic inflammation in the airways, and its antagonists could exert an anti-inflammatory effect in chronic asthma.

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18 References

Prostaglandin D2 Plays an Essential Role in Chronic Allergic Inflammation of the Skin via CRTH2 Receptor1

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PGs play key regulatory roles in inflammation and immunity. PGD2, released from mast cells and Th2 cells during allergic responses, has recently been shown to target a novel receptor, chemoattractant

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