Pellagra: Dermatitis, dementia, and diarrhea

@article{Hegyi2004PellagraDD,  title={Pellagra: Dermatitis, dementia, and diarrhea},  author={Juraj Hegyi and Robert A. Schwartz and Vladim{\'i}r Hegyi},  journal={International Journal of Dermatology},  year={2004},  volume={43},  url={https://api.semanticscholar.org/CorpusID:33877664}}
The findings of this once mysterious disorder, one that still challenges clinicians world‐wide, are reviewed.

342 Citations

Isoniazid-induced pellagra

A 7-year-old boy presenting with INH-induced pellagra that resolved after the administration of the niacin therapy is reported.

Case report: Pellagra presentation with dermatitis and dysphagia

It is highlighted that dermatitis and dysphagia, the main gastrointestinal manifestations, can be the only symptoms in patients with pellagra, requiring a high index of suspicion in dermatologic settings to diagnose and treat this fatal condition early.

Hidden Hunger: A Pellagra Case Report

The case of a woman with a clinical picture of hyperpigmentation and hyperkeratinization in exposed areas of the skin, watery diarrhea, and progressive disorientation with disorganized speech is reported, which highlights the need to maintain a high index of suspicion in the presence of characteristic symptoms for timely diagnosis of this deadly condition.

Chronic Diarrhea and Alcoholism: Unravelling the Connection to Pellagra

The need for a high index of suspicion when diagnosing pellagra in vulnerable populations to ensure prompt treatment and recovery is emphasized.

Pellagra dermatitis: five cases with dermoscopic findings

Five cases of pellagra dermatitis with dermoscopic findings are reported, with three males and two females, their ages ranging from 26 to 36 years (mean age, 31 years), who had photosensitivity with a burning sensation and dry, scaly skin lesions over photoexposed areas.

Pellagra a review exploring causes and mechanisms, including isoniazid‐induced pellagra

Increased use of isoniazid prophylaxis along with antiretroviral therapy in countries where latent tuberculosis is common has been associated with increased presentations with pellagra.

The photosensitive patient: could it be pellagra?

Whether photosensitivity in pellagra is a photoaggravated dermatosis or a primary photosensitivity disorder can be definitively defined only with systematic phototesting, which has not been reported thus far.

Pellagra: An Unusual Cause for Altered Mental Status

The case report highlights the importance of considering pellagra in the differential diagnosis for certain high-risk patients presenting with altered mental status as it has not been completely eradicated yet.

Pellagra: An uncommon disease in the modern era - A case report

An adult female with classical features of pellagra but lacking involvement of face and neck, possibly due to dietary deficiency is described with a view to highlight that a strong clinical suspicion and careful socio-nutritional history is important to avoid missing such cases.
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30 References

Pellagra: a sporadic pediatric case with a full triad of symptoms.

A case of a 14-year-old boy with classic symptoms of pellagra, who all his symptoms responded to treatment with nicotinic acid.

Pellagra and the carcinoid syndrome.

In a 63-year-old black woman, oral and parenteral administration of niacinamide (nicotinamide; the amide form of niakin) led to rapid clearing of the pellagrous dermatitis.

Pellagra in 2 homeless men.

The combination of homelessness, alcohol abuse, and failure to eat regularly--particularly, failure to make use of shelter-based meal programs--may identify people at special risk in contemporary settings.

Pellagra and skin

This disease, which killed thousands in the United States as recently as 1930, is all but eradicated as a result of great advances in public health in developed countries and improvements in nutrition and enrichment of wheat flour with nicotinic acid.

Pellagra secondary to 5‐fluorouracil

A patient who presented with the typical skin changes of pellagra, and an associated acute deterioration in cerebral function, were exacerbated by treatment with 5‐fluorouracil, indicating the importance of considering nicotinic‐acid deficiency in patients with malignant disease.

Pellagra: a still existing disease

Pellagra is no longer the medico-social problem it was in the past but in countries with a low nutritional level it continues to a considerable degree in endemic form and in areas of the so-called 'civilized world' where nutritional problems do not really exist, occasional cases are found.

Isoniazid induced pellagra despite pyridoxine supplementation

A case of isoniazid‐induced pellagra which occurred despite pyridoxine supplementation is reported, and drug withdrawal and supplementation with niacin led to a rapid and sustained clinical improvement.

A Plaque of Corn: The Social History of Pellagra

This small volume should interest primarily the medical sociologist, medical historian, and the politician in whose country pellagra is present.

Pellagra in a patient with an eating disorder

Urinary 5‐hydroxy‐indole‐acetic acid was found to be low and it is suggested that this may be a useful screening test for an eating disorder.

[Prevalence of HIV infection in patients with pellagra and pellagra-like erythemas].

The findings of this study suggest that the incidence of HIV infection in patients withpellagra and pellagra-like erythema is low, i.e., not higher than in the general population.

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