Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities

@article{Morita2005InhibitionOS,  title={Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities},  author={Katsuya Morita and Masahiro Hamamoto and Shigeaki Arai and Shigeo Kitayama and Masahiro Irifune and Michio Kawahara and Kenji Kihira and Toshihiro Dohi},  journal={Brain Research},  year={2005},  volume={1057},  pages={153-160},  url={https://api.semanticscholar.org/CorpusID:30437231}}

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40 References

Cocaine-induced convulsions: pharmacological antagonism at serotonergic, muscarinic and sigma receptors

Of the CNS binding sites with which cocaine is known to interact, the results are consistent with the conclusion that 5-HT transporters and5-HT2 receptor sites appear to be direct and primary sites related to cocaine-induced convulsions, while M1 and sigma binding sites seem to play important but secondary and modulatory roles in this response.

Fluoxetine, but not sertraline or citalopram, potentiates the locomotor stimulant effect of cocaine: possible pharmacokinetic effects

Fluoxetine enhanced the ability of cocaine to increase locomotor activity, and the results indicate that 5-HT reuptake inhibition may not play a prominent role in mediating the stimulant effects of cocaine.

Serotonin2C receptors appear to mediate genetic sensitivity to cocaine-induced convulsions

Previous research suggests that the 5-HT2C receptor subtype mediates cocaine-induced convulsions and genetic sensitivity to this toxic effect of cocaine, and the findings from this study support this suggestion.

Cocaine: evidence for NMDA-, beta-carboline- and dopaminergic-mediated seizures in mice.

The results suggest that the cocaine-induced convulsion may involve an activation of the NMDA-Ca ionophore complex system, which is mediated by the dopaminergic system, and a beta-carboline recognition site other than the benzodiazepine/GABAA receptor-Cl ionophor complex system.

Selective inhibition of monoamine neurotransmitter transporters by synthetic local anesthetics

Kinetic analysis of monoamine uptake inhibition by procaine in COS cells expressing rat DAT, NET or SERT revealed a competitive action similar to that of cocaine, demonstrating that certain LAs selectively inhibit monoamine transporters.

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