Hydrogen Sulfide and Colonic Epithelial Metabolism

@article{Jrgensen2001HydrogenSA,  title={Hydrogen Sulfide and Colonic Epithelial Metabolism},  author={Jimmy J{\o}rgensen and Per Br{\o}bech Mortensen},  journal={Digestive Diseases and Sciences},  year={2001},  volume={46},  pages={1722-1732},  url={https://api.semanticscholar.org/CorpusID:30373968}}
Fecal HS− has little effect on butyrate oxidation in colonocytes and does not seem to play a pathogenic role for UC by impairing colonic epithelial metabolism, while other fecal agents seem to be more potent metabolic inhibitors than fecal HS −.

39 Citations

Detoxification of H(2)S by differentiated colonic epithelial cells: implication of the sulfide oxidizing unit and of the cell respiratory capacity.

It is found that 50 μM sodium hydrogen sulfide represents the threshold of concentration above which respiration is decreased and cell respiratory capacity and SOU activity appear to represent major determinants allowing sulfide detoxification in colonic epithelial cells.

Decreased mucosal sulfide detoxification is related to an impaired butyrate oxidation in ulcerative colitis

An impaired detoxification mechanism of sulfide at TST protein and RNA level in UC was found andlammation was clearly associated with the observed TST deficiency.

Role of Hydrogen Sulfide in Inflammatory Bowel Disease

The aim of this review is to summarize the available literature published until June 2023 in order to provide an overview of the current knowledge of the connection between H2S and IBD.

Hydrogen sulfide signaling in the gastrointestinal tract.

It is clear from the current literature that the long-appreciated relationship between H2S and the gastrointestinal tract continues to be strong as it endeavor to unravel its mysteries.

Butyrate-stimulated H2S production in colon cancer cells.

Butyrate regulates endogenous H(2)S production by stimulating CBS expression in colon cancer cells, but butyrate and H( 2)S inhibit cancer cell growth through different mechanisms.

Reduced Sulfur Diet Reshapes the Microbiome and Metabolome in Mild–Moderate Ulcerative Colitis

In conclusion, a RS diet promoted microbial diversity, metabolic adaptations, and reduced inflammation, highlighting its potential as a novel strategy for UC management.

Terminal Oxidase Cytochrome bd Protects Bacteria Against Hydrogen Sulfide Toxicity

The key role of non-canonical bd-type terminal oxidases of the enterobacterium Escherichia coli, a component of the gut microbiota, in maintaining aerobic respiration and growth in the presence of toxic concentrations of H2S is discussed.

35 References

Sulphide impairment of substrate oxidation in rat colonocytes: a biochemical basis for ulcerative colitis?

A hypothesis for the disease process of ulcerative colitis is that sulphides may form persulphides with butyryl-CoA, which would inhibit cellular short-chain acyl- CoA deHydrogenase and beta-oxidation to induce an energy-deficiency state in colonocytes and mucosal inflammation.

Influence of Feces from Patients with Ulcerative Colitis on Butyrate Oxidation in Rat Colonocytes

Feces from healthy subjects and patients with quiescent and active ulcerative colitis containhibitor(s) of the production of CO2 from butyrate oxidation in colonocytes, however, a specific inhibitory effect of feces from patients with ulceratives colitis on the productionof CO2 could not be identified.

Hydrogen sulphide produces diminished fatty acid oxidation in the rat colon in vivo: implications for ulcerative colitis.

Sodium hydrosulphide impairs rat colonic epithelial metabolic performance in vivo, but does not produce mucosal inflammation.

Short chain fatty acid and glucose metabolism in isolated pig colonocytes: modulation by NH4+

It is concluded that ammonia, whose physiological concentration is high in the colonic lumen, can modulate the metabolism of two major substrates, n-butyrate and glucose, in colonic epithelial cells.

Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man.

The hypothesis is put forward that fatty acids of anaerobic bacteria are a major source of energy for the colonic mucosa, particularly of the distal colon.

Production and elimination of sulfur-containing gases in the rat colon

Using a rat model, the production and elimination of sulfur-containing gases within the unperturbed colon was studied via a sixfold reduction with fasting and a fivefold increase with carrageenan (a nonabsorbable, sulfur compound) feeding.

Colonic Luminal Hydrogen Sulfide Is Not Elevated in Ulcerative Colitis

The results do not support a primary etiologic role for luminal sulfide in ulcerativecolitis, and exposure to reduced forms of sulfur derived from Dissimilatory sulfate reduction by luminal microflora is still considered.

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