Syndromes of Glucocorticoid Resistance

@article{Chrousos1993SyndromesOG,  title={Syndromes of Glucocorticoid Resistance},  author={George P. Chrousos and Sevilla D Detera-Wadleigh and Michael Karl},  journal={Annals of Internal Medicine},  year={1993},  volume={119},  pages={1113-1124},  url={https://api.semanticscholar.org/CorpusID:26040431}}
Although the increased cortisol concentrations in most affected persons appear to compensate adequately for the inability of target tissues to respond to glucocorticoids, the excess corticotropin secretion results in the increased production of intermediate compounds in adrenal steroidogenesis that have salt-retaining activity and in the enhanced secretion of adrenal androgens.

246 Citations

Syndromes of Glucocorticoid Resistance

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91 References

Steroid hormone resistance. Mechanisms and clinical aspects.

This volume represents the first attempt to present in one place the clinical syndromes and the pathophysiologic basis for the "resistance states" to each of the classes of steroid hormones.…

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AIDS patients with hypercortisolism and clinical features of peripheral resistance to glucocorticoids are characterized by abnormal glucOCorticoid receptors on lymphocytes, which implies a complex change in immune-endocrine function, which may be important in the course of immunodeficiency syndrome.

Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.

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Glucocorticoid physiology, pharmacology and stress.

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Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene.

The molecular mechanisms of this syndrome in a Dutch kindred, whose affected members had hypercortisolism and approximately half of normal GRs, and whose proband was a young woman with manifestations of hyperandrogenism, were studied.

Glucocorticoid receptor abnormalities in fibroblasts from patients with idiopathic resistance to dexamethasone diagnosed when evaluated for adrenocortical disorders.

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Results suggest that the patient's glucocorticoid resistance was due to a decrease in the affinity of the receptor for glucoc Corticoids and a decreases in the binding of the GR complex to DNA.

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Therapy with dexamethasone was successful in female patients with acne and hirsutism, as the secondary increase in the production of adrenal androgens was effectively controlled.

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