The Benzamide Tiapride: Treatment of Extrapyramidal Motor and Other Clinical Syndromes

@article{Dose2000TheBT,  title={The Benzamide Tiapride: Treatment of Extrapyramidal Motor and Other Clinical Syndromes},  author={Matthias Dose and Lange Hw},  journal={Pharmacopsychiatry},  year={2000},  volume={33},  pages={19 - 27},  url={https://api.semanticscholar.org/CorpusID:26269168}}
in vitro 

33 Citations

Efficacy of tiapride in the treatment of psychiatric disorders: A systematic review

This work aims to systematically review the available evidence on the efficacy and tolerability of tiapride in individuals with a psychiatric disorder.

Early Administration of Tiapride to Young Rats without Long-lasting Changes in the Development of the Dopaminergic System

This paper presents a probabilistic procedure to estimate the number of neurons in the response of the immune system to the presence of certain types of viruses.

Treatment of alcohol withdrawal: tiapride and carbamazepine versus clomethiazole.

Compared the combination of TIA and CBZ with CLO in two open exploratory studies with matched samples, which revealed similar efficacy in terms of psychopathologic and vegetative symptoms and Vegetative recovery seems to be faster with TIA+CBZ.

Separation Anxiety Triggered by Atypical Neuroleptic Medication in an Adolescent with Tourette’s Syndrome

The case of a 13-year-old male Tourette’s syndrome patient who developed separation anxiety disorder during combined treatment with risperidone and tiapride is described.

Weak Inhibitors Protect Cholinesterases from Stronger Inhibitors (Dichlorvos): In Vitro Effect of Tiapride

The purpose of the study was to quantify in vitro the extent of TIA-conferred protection, using dichlorvos (dichlorovinyl dimethyl phosphate; DDVP) as an inhibitor, and conclude that in vivo testing of Tia as an OP protective agent is warranted.

Tiapride for the Treatment of Auditory Hallucinations in Schizophrenia

Two cases are reported where tiapride was useful as an add-on drug for treating persistent auditory hallucinations in patients with schizophrenia.

Pregabalin, tiapride and lorazepam in alcohol withdrawal syndrome: a multi-centre, randomized, single-blind comparison trial.

The efficacy of pregabalin was superior to that of tiapride, used largely in research trials and, for some measures, to the 'gold standard', lorazepam.

Update on the role of antipsychotics in the treatment of Tourette syndrome

The present review aims to summarize the current and evidence-based knowledge on the risk-benefit ratio of both first and second generation neuroleptics in TS.

[Therapy of tic-disorders].

Risperidone may become the first-line drug in treatment of tic disorders and behaviour therapy might be increasingly used within a multimodal treatment program.

44 References

Tiapride in the Treatment of Tardive Dyskinesia A Double-blind Study

In animal models it antagonises perioral dyskinesias induced by striatal injection of dopaminergic substances, but it fails to induce catalepsy.

Neuroleptic side effects: acute extrapyramidal syndromes and tardive dyskinesia.

The pressing need is for novel compounds which treat schizophrenia and are free of the undesirable motor system effects (a nonneuroleptic neuroleptic).

Tiapride: effects on tardive dyskinesia and on prolactin plasma concentrations.

In a placebo-controlled double-blind crossover study of 21 patients chronically treated with neuroleptics and suffering from tardive dyskinesia, tiapride exhibited a transient efficacy during 12 weeks of treatment, most distinct in the 6th week.

The Effects of Clozapine on Tardive Dyskinesia

Data indicate that TD response to clozapine is variable but that approximately 43% of cases, particularly those with dystonic features, improved after clozAPine treatment.

Tiapride in the treatment of tardive dyskinesia

The effect was measured by a Doppler‐radar device and by counting the number of involuntary movements from video‐recordings and subjective assessments were made on analogue scales by family, nurses and attendant doctors.

Neuropharmacology of the extrapyramidal system.

A thorough investigation of the neuroanatomy and neuropharmacology of the extrapyramidal system is undertaken, and an attempt is made to delineate the roles of other neurotransmitters and neuromodulators that play an important role in its functioning.

Tiapride. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in geriatric agitation.

Results from limited studies indicate that the clinical efficacy of tiapride in the treatment of agitation, aggressiveness, anxiety and sleep disorders in the elderly appears superior to that of placebo, chlorpromazine, lorazepam and meprobamate.

Measuring the efficacy of psychopharmacological treatment of psychomotoric restlessness in dementia: clinical evaluation of tiapride.

It is demonstrated that tiapride is as effective and as safe as melperone in hospitalized dementia patients suffering from psychomotoric agitation.

Tiapride in the Long-term Management of Alcoholics of Anxious or Depressive Temperament

Patients treated with tiapride drank less and had longer periods of abstinence, associated with improvements in laboratory tests, reduction in neurotic symptoms, gains in self-esteem and increased levels of expressed satisfaction with life situation.

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