Contraceptive efficacy of testosterone-induced azoospermia in normal men

@article{1990ContraceptiveEO,  title={Contraceptive efficacy of testosterone-induced azoospermia in normal men},  author={},  journal={The Lancet},  year={1990},  volume={336},  pages={955-959},  url={https://api.semanticscholar.org/CorpusID:25825354}}

216 Citations

Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study. II. Pharmacokinetics and pharmacodynamics of once weekly administration of testosterone enanthate.

It is concluded that the polymorphism of spermatogenic suppression in response to exogenous T is unlikely to be due to differences in the pharmacokinetics or pharmacodynamics of TE or in the sensitivity of the hypothalamo-pituitary-testicular axis to sex steroid inhibition.

Depot testosterone with etonogestrel implants result in induction of azoospermia in all men for long-term contraception.

The combination of three etonogestrel implants with depot testosterone results in rapid and consistent suppression of spermatogenesis, which can be maintained for up to 1 year and may be a suitable approach for a long-acting male hormonal contraceptive.

Suppression of human spermatogenesis by testosterone implants.

A depot testosterone preparation with quasi-zero-order release demonstrates higher dose efficiency with similar (but not uniform) efficacy at inducing azoospermia but may cause fewer androgenic side-effects than weekly TE injections.

A multicenter contraceptive efficacy study of injectable testosterone undecanoate in healthy Chinese men.

It is shown that monthly TU injection at a dose of 500 mg after an initial loading dose of 1000 mg can effectively, safely, and reversibly suppress spermatogenesis in healthy Chinese men without serious adverse effects.

Investigation of hormonal male contraception in African men: suppression of spermatogenesis by oral desogestrel with depot testosterone.

Data demonstrate that the combination of oral desogestrel with depot testosterone is an effective regimen for suppression of spermatogenesis in African as in Caucasian and Chinese men, with azoospermia achieved in a total of 83/98 (85%) men.

Low dose of cyproterone acetate and testosterone enanthate for contraception in men.

It is suggested that an hormonal regimen consisting of testosterone plus a progestin with anti-androgenic properties holds promise as an effective, safe and reversible male contraceptive.

A clinical trial of injectable testosterone undecanoate as a potential male contraceptive in normal Chinese men.

It is concluded that both dosages of TU can effectively, safely, and reversibly suppress spermatogenesis in normal Chinese men.

Male hormonal contraception: effects of injections of testosterone undecanoate and depot medroxyprogesterone acetate at eight-week intervals in chinese men.

An 8-wk regimen of TU plus DMPA at both tested combination doses effectively suppressed spermatogenesis to azoospermia in Chinese men and is recommended for further testing in an expanded clinical trial or contraceptive efficacy study.

Contraceptive efficacy of a depot progestin and androgen combination in men.

The first male contraceptive efficacy study using a prototype depot androgen/progestin combination demonstrates high contraceptive efficacy with satisfactory short-term safety and recovery of spermatogenesis.
...

Related Papers

Showing 1 through 3 of 0 Related Papers