• Corpus ID: 23788795

Clinical Guideline : Evaluation of Abnormal Liver Chemistries

@inproceedings{Kwo2016ClinicalG,  title={Clinical Guideline : Evaluation of Abnormal Liver Chemistries},  author={Paul Yien Kwo and Faasld Facg and Stanley M. Cohen and Joseph K. Lim},  year={2016},  url={https://api.semanticscholar.org/CorpusID:23788795}}
A formal review and literature search of the world literature on MEDLINE and EMBASE databases dealing with the evaluation of abnormal liver chemistries, studies that dealt with normal or reference range for alanine aminotransferase (ALT) levels and what thresholds trigger an evaluation for actionable liver disease are found.
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815 Citations

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92 References

AGA technical review on the evaluation of liver chemistry tests.

To provide high-quality, cost-effective health care, a rational approach for the appropriate evaluation of serum liver chemistries is essential for all practicing physicians.

Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests.

The international normalized ratio should not be the sole method for reporting results of prothrombin time in liver disease; additional research is needed to determine the reporting mechanism that best correlates with functional impairment.

Evaluation of abnormal liver-enzyme results in asymptomatic patients.

Now that routine laboratory testing is automated and is frequently part of an annual checkup, physicians are often faced with the problem of a patient with one abnormal result on measurement of serum…

Diagnosis and Monitoring of Hepatic Injury. II. Recommendations for Use of Laboratory Tests in Screening, Diagnosis, and Monitoring

Although ALT is useful for detecting acute and chronic hepatic injury, it is not related to severity of acute Hepatitis B and C and only weakly related to severe severity of chronic hepatics injury.

Liver enzyme alteration: a guide for clinicians

In this review, a schematic approach is used that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, and abnormal enzymatic activity within the 2 subgroups are reviewed.

Prevalence of Abnormal Liver Function Tests in Celiac Disease and the Effect of a Gluten-Free Diet in the US Population

Forty percent of individuals will have elevated LFTs at CD diagnosis; however, the majority will normalize with standard CD therapy and should be checked in all patients with CD and coexisting liver disorder should be considered in patients whoseLFTs have not improved within a year on a GFD.

A practice guideline on Wilson disease

These guidelines provide data-supported approaches to the diagnosis and management of patients with Wilson disease that are based on broad-based review of the published literature in pediatrics and medicine and 40 accumulated years of personal experience of the authors.

AGA technical review on nonalcoholic fatty liver disease.

In this review, the existing literature regarding the nomenclature, clinical and histologic spectrum, natural history, diagnosis, and management of nonalcoholic fatty liver disease are discussed.

Introduction to the Revised American Association for the Study of Liver Diseases Position Paper on Acute Liver Failure 2011

Fulminant Wilson's disease can be diagnosed most effectively not by waiting for copper levels (too slow to obtain) or by obtaining ceruloplasmin levels (low in half of all ALF patients, regardless of etiology), but by simply looking for the more readily available bilirubin level and alkaline phosphatase (ALP; very low).
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