Fungal secondary metabolism — from biochemistry to genomics

@article{Keller2005FungalSM,  title={Fungal secondary metabolism — from biochemistry to genomics},  author={Nancy P. Keller and Geoffrey Turner and Joan W Bennett},  journal={Nature Reviews Microbiology},  year={2005},  volume={3},  pages={937-947},  url={https://api.semanticscholar.org/CorpusID:23537608}}
Questions are addressed, including which evolutionary pressures led to gene clustering, why closely related species produce different profiles of secondary metabolites, and whether fungal genomics will accelerate the discovery of new pharmacologically active natural products.

1,592 Citations

10 Evolution of Genes for Secondary Metabolism in Fungi

An overview of secondary metabolite genes in different fungal groups is given, some of the principles of the regulation of expression of these genes are addressed, and what is known about the biological functions of secondary metabolites in fungi is summarized.

Secondary Metabolites of Fungal Vine Pathogens

Investigation into natural product research concerning the biosynthetic potential of producing organisms are often hampered by the fact that production of these metabolites is sensitive to culture conditions, therefore, the metabolites produced in axenic culture do not match the spectrum of natural products produced within the environment.

Biological activity of fungal secondary metabolites

Fungi, filamentous forms, produce a diverse array of secondary metabolites that are small molecules, and not necessary for normal growth or development, which are still more or less a mystery.

Biologically active secondary metabolites from white-rot fungi

The present paper reviews the secondary metabolites produced by white-rot fungi with different interesting bioactivities including some compounds with antimicrobial and anticancer properties that could be of potential interest for the pharmaceutical industries.

Analysis of Secondary Metabolites from Plant Endophytic Fungi.

This chapter describes the procedures for fungal fermentation, metabolite extraction, and analysis using high-performance liquid chromatography (HPLC) of the endophytic fungus Pestalotiopsis fici, which produces 88 secondary metabolites including 70 new natural products.
...

123 References

Biological Activities of Fungal Metabolites

The amazing range of chemical structures observed for fungal metabolites is derived from a relatively small number of basic metabolic pathways, plus combinations of these, which have become extremely diversified during the course of evolution.

Secondary metabolites: their function and evolution.

Partial table of contents: Origins of Secondary Metabolism (T. Cavalier-Smith) Genes for Polyketide Secondary Metabolic Pathways in Microorganisms and Plants (D. Hopwood & C. Khosla) Regulation of

LaeA, a Regulator of Secondary Metabolism in Aspergillus spp

A novel Aspergillus nuclear protein, LaeA, is presented here as a global regulator of secondary metabolism in this genus, and strains show little difference in spore production compared to the wild type, indicating that the primary role of laeA is to regulate metabolic gene clusters.

Relationship between Secondary Metabolism and Fungal Development

In the case of the filamentous fungus Aspergillus nidulans, the only described work that genetically links the sporulation of this fungus to the production of the mycotoxin sterigmatocystin through a shared G-protein signaling pathway is reviewed.

G‐protein signalling mediates differential production of toxic secondary metabolites

Findings reveal that a G‐protein defines an important control point for differential expression of fungal secondary metabolites within and across fungal genera, and provide critical evidence suggesting that targeting G‐ protein signal transduction pathways as a means of controlling or preventing the production of a single mycotoxin could have serious undesirable consequences with regard to theProduction of other secondary metabolites.

Genetics and Biosynthesis of Aflatoxins and Sterigmatocystin

Two chemically related fungal secondary metabolites that have been studied extensively are the mycotoxins sterigmatocystin (ST) and aflatoxin (AF), produced by several Aspergillus species.

Molecular Regulation of β-Lactam Biosynthesis in Filamentous Fungi

A comparison with the regulatory mechanisms (regulatory proteins and DNA elements) involved in the regulation of genes of primary metabolism in lower eukaryotes is thus of great interest and can be expected to have a major impact on rational strain improvement programs.

Secondary Metabolism in Microorganisms, Plants and Animals

This book shows that the formation of sec ondary products is a common characteristic of specialized cells brought about by the action of special enzymes encoded by specific genetic material.

Ergot Alkaloids: Chemistry, Biological Effects, Biotechnology

This work focuses on the role of alkaloids in the life system of Claviceps and their role in biocatalysis, which is involved in the biosynthesis and storage of alkaloids.
...

Related Papers

Showing 1 through 3 of 0 Related Papers