Plant derivatives in the treatment of alcohol dependency

@article{Rezvani2003PlantDI,  title={Plant derivatives in the treatment of alcohol dependency},  author={Amir H. Rezvani and David H. Overstreet and Marina Cecilia Perfumi and Maurizio Massi},  journal={Pharmacology Biochemistry and Behavior},  year={2003},  volume={75},  pages={593-606},  url={https://api.semanticscholar.org/CorpusID:23298356}}

93 Citations

Reduction of ethanol intake by chronic treatment with Hypericum perforatum, alone or combined with naltrexone in rats

Evidence is provided for a selective and pronounced effect of HPCO2, alone or combined with naltrexone, on ethanol intake in conditions of chronic treatment, without development of tolerance, and support the view that clinical trials for extracts of Hypericum perforatum in the treatment of alcoholism should be considered.

Phytotherapy of Alcoholism

Can drugs of natural origin be helpful in the treatment of alcoholism or in decreasing alcohol consumption?

Application of kudzu flowers to reduce beer toxicity

In the course of studies, a positive effect of the extract from kudzu flowers on the resistance of yeast to ethanol stress and, as a consequence, on their physiological activity was established, and it was concluded that it was advisable to add the extract to beer after the filtration process.

Puerarin: A Review of Pharmacological Effects

The beneficial effects of puerarin on the various medicinal purposes may be due to its wide spectrum of pharmacological properties such as vasodilation, cardioprotection, neuroprotection, antioxidant, anticancer, antiinflammation, alleviating pain, promoting bone formation, inhibiting alcohol intake, and attenuating insulin resistance.

O extrato bruto hidroalcoólico das folhas de Piper caldense C. DC. na redução do consumo de álcool em ratos.

The results suggest that the hydroalcoholic extract of leaves of Piper caldense C. DC has potential to combat alcohol abuse and addiction and also its anxiolytic potentiality.

Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female Rats

The present results indicate for the first time that Hypericum perforatum extracts may have therapeutic properties in bingeing-related eating disorders.
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124 References

Herbal remedies for alcoholism: promises and possible pitfalls.

This review summarizes the findings of the effects on alcohol intake in alcohol-preferring rats of extracts or purified compounds from two of the most promising herbs: kudzu (Pueraria lobata) and St.…

Isoflavonoid compounds extracted from Pueraria lobata suppress alcohol preference in a pharmacogenetic rat model of alcoholism.

Data demonstrate that isoflavonoid compounds extracted from Pueraria lobata is effective in suppressing the appetite for alcohol when taken orally, raising the possibility that other constituents of edible plants may exert similar and more potent actions.

Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives.

NPI-028 and one of its pure components, NPI-031G, selectively reduced alcohol intake in alcohol-preferring rats and significantly reduced ethanol intake in FH rats without affecting food or water intake.

Daidzin, an antioxidant isoflavonoid, decreases blood alcohol levels and shortens sleep time induced by ethanol intoxication.

Interestingly, daidzin, whether fed to rats only once or chronically for 7 days, did not significantly alter activities of either alcohol dehydrogenase or mitochondrial aldehyde dehydrogenases in the liver.

Attenuation of alcohol intake by extract of Hypericum perforatum (St. John's Wort) in two different strains of alcohol-preferring rats.

Promising findings suggest that SJW extract should be evaluated clinically as a potential therapeutic agent in the treatment of alcoholism.

Effects of Hypericum perforatum extraction on alcohol intake in Marchigian Sardinian alcohol-preferring rats.

HPE markedly reduces ethanol intake in msP rats, without significantly modifying food intake, and is not related to changes in the pharmacokinetics of ethanol.

Effects of a methanolic extract and a hyperforin-enriched CO2 extract of Hypericum perforatum on alcohol intake in rats.

The present results indicate that HPE 2 inhibits ethanol intake more potently than HPE1; the higher potency of HPE2 parallels the hyperforin content, suggesting that hyper forin may have an important role in reducing ethanol intake.
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